Interplay Between LOX Enzymes and Integrins in the Tumor Microenvironment

ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis

(2019) Vinit Shanbhag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collagen remodeling in the hypoxic tumor-mesothelial niche promotes ovarian cancer metastasis

(2019) Suchitra Natarajan et al.   CANCER RESEARCH

Lysyl oxidase–like 2 (LOXL2)–mediated cross-linking of tropoelastin

(2019) Christian E. H. Schmelzer et al.   FASEB JOURNAL

LOXL2—A New Target in Antifibrogenic Therapy?

(2019) Angela Puente et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of the lox enzyme family members with old and new ligands. selectivity analysis revisited

(2018) István Hajdú et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Simtuzumab Is Ineffective for Patients with Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis

(2018) Stephen A. Harrison et al.   GASTROENTEROLOGY

527 Targeting Lysyl Oxidase (LOX) Activity to Improve Scar Appearance

(2018) N Chaudhari et al.   Journal of Burn Care & Research

Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation

(2018) Sifan Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state

(2018) Xi Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cells’ ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential

(2018) Lena Wullkopf et al.   MOLECULAR BIOLOGY OF THE CELL

The lysyl oxidase like 2/3 enzymatic inhibitor, PXS‐5153A, reduces crosslinks and ameliorates fibrosis

(2018) Heidi Schilter et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

(2017) Martin W. Rowbottom et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX

(2017) John H. Hutchinson et al.   ACS Medicinal Chemistry Letters

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

(2017) HaoRan Tang et al.   Nature Communications

LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer

(2017) Sul Ki Choi et al.   Oncotarget

Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer

(2017) Joan Chang et al.   Oncotarget

Clinical trial research in focus: why do so many clinical trials fail in IPF?

(2017) Paolo Spagnolo et al.   Lancet Respiratory Medicine

Efficacy of simtuzumab versus placebo in patients with idiopathic pulmonary fibrosis: a randomised, double-blind, controlled, phase 2 trial

(2017) Ganesh Raghu et al.   Lancet Respiratory Medicine

Lysyl oxidase expression in cardiac fibroblasts is regulated by α2β1 integrin interactions with the cellular microenvironment

(2016) Albert E. Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice

(2016) Susan B. Liu et al.   FASEB JOURNAL

Lysyl Oxidase-like-2 Cross-links Collagen IV of Glomerular Basement Membrane

(2016) Carolina Añazco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice

(2016) Jian Zhang et al.   Scientific Reports

LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival

(2015) S. Torres et al.   CLINICAL CANCER RESEARCH

Upregulation of Periostin and Reactive Stroma Is Associated with Primary Chemoresistance and Predicts Clinical Outcomes in Epithelial Ovarian Cancer

(2015) L. Ryner et al.   CLINICAL CANCER RESEARCH

Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression

(2015) A. Martin et al.   EMBO JOURNAL

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

(2015) Bryan W Miller et al.   EMBO Molecular Medicine

Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice

(2015) Jian Zhang et al.   HUMAN MOLECULAR GENETICS

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype

(2015) Luke Cassereau et al.   JOURNAL OF BIOTECHNOLOGY

Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network

(2015) Vira V. Artym et al.   JOURNAL OF CELL BIOLOGY

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

(2015) Thomas R. Cox et al.   NATURE

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer

(2015) R Navab et al.   ONCOGENE

Origin and evolution of lysyl oxidases

(2015) Xavier Grau-Bové et al.   Scientific Reports

Targeting ECM Disrupts Cancer Progression

(2015) Freja A. Venning et al.   Frontiers in Oncology

Increasing matrix stiffness upregulates vascular endothelial growth factor expression in hepatocellular carcinoma cells mediated by integrin β1

(2014) Yinying Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Pathways: Connecting Fibrosis and Solid Tumor Metastasis

(2014) T. R. Cox et al.   CLINICAL CANCER RESEARCH

ECM stiffness regulates glial migration in Drosophila and mammalian glioma models

(2014) S. N. Kim et al.   DEVELOPMENT

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Lysyl oxidase-like 4 (LOXL4) promotes proliferation and metastasis of gastric cancer via FAK/Src pathway

(2014) Rong-kun Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

LOXL2 Status Correlates with Tumor Stage and Regulates Integrin Levels to Promote Tumor Progression in ccRCC

(2014) H. Hase et al.   MOLECULAR CANCER RESEARCH

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression

(2014) Janna K Mouw et al.   NATURE MEDICINE

Upregulated Copper Transporters in Hypoxia-Induced Pulmonary Hypertension

(2014) Adriana M. Zimnicka et al.   PLoS One

Microenvironmental Stiffness Enhances Glioma Cell Proliferation by Stimulating Epidermal Growth Factor Receptor Signaling

(2014) Vaibhavi Umesh et al.   PLoS One

LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients

(2013) Sung Gwe Ahn et al.   BREAST CANCER RESEARCH AND TREATMENT

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

(2013) T. R. Cox et al.   CANCER RESEARCH

Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor- -Deficient Mouse Mammary Carcinomas

(2013) M. W. Pickup et al.   CANCER RESEARCH

A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer

(2013) Dong-Joo Cheon et al.   CLINICAL CANCER RESEARCH

LOXL4 Is Induced by Transforming Growth Factor  1 through Smad and JunB/Fra2 and Contributes to Vascular Matrix Remodeling

(2013) O. Busnadiego et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling

(2013) H. E. Barker et al.   MOLECULAR CANCER RESEARCH

An Overview and Update ofATP7AMutations Leading to Menkes Disease and Occipital Horn Syndrome

(2012) Zeynep Tümer   HUMAN MUTATION

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

(2012) A-M Baker et al.   ONCOGENE

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane

(2011) M. Bignon et al.   BLOOD

LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution

(2011) H. E. Barker et al.   CANCER RESEARCH

Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling

(2011) Tetyana G. Voloshenyuk et al.   CYTOKINE

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas

(2011) Gema Moreno-Bueno et al.   EMBO Molecular Medicine

The Role of Lysyl Oxidase in SRC-Dependent Proliferation and Metastasis of Colorectal Cancer

(2011) Ann-Marie Baker et al.   JNCI-Journal of the National Cancer Institute

The Conserved Scavenger Receptor Cysteine-Rich Superfamily in Therapy and Diagnosis

(2011) V. G. Martinez et al.   PHARMACOLOGICAL REVIEWS

Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity

(2011) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment

(2010) D. Barkan et al.   CANCER RESEARCH

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Lysyl oxidase expression and inhibition in uveal melanoma

(2010) Daniel A. Abourbih et al.   MELANOMA RESEARCH

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

(2010) Y. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway

(2009) Liang Peng et al.   CARCINOGENESIS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

MT2-MMP-Dependent Release of Collagen IV NC1 Domains Regulates Submandibular Gland Branching Morphogenesis

(2009) Ivan T. Rebustini et al.   DEVELOPMENTAL CELL

Menkes disease

(2009) Zeynep Tümer et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC)

(2009) Andrea Albinger-Hegyi et al.   INTERNATIONAL JOURNAL OF CANCER

Validation of Lysyl Oxidase As a Prognostic Marker for Metastasis and Survival in Head and Neck Squamous Cell Carcinoma: Radiation Therapy Oncology Group Trial 90-03

(2009) Quynh-Thu Le et al.   JOURNAL OF CLINICAL ONCOLOGY

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Differential expression of the LOX family genes in human colorectal adenocarcinomas

(2009) Kim   ONCOLOGY REPORTS

The Lysyl Oxidase Inhibitor, β-Aminopropionitrile, Diminishes the Metastatic Colonization Potential of Circulating Breast Cancer Cells

(2009) Alla Bondareva et al.   PLoS One

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer

(2008) Theresa Casey et al.   BREAST CANCER RESEARCH AND TREATMENT

Lysyl Oxidase-Like 2 as a New Poor Prognosis Marker of Squamous Cell Carcinomas

(2008) H. Peinado et al.   CANCER RESEARCH

The Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survival

(2008) Nigel P. S. Crawford et al.   CLINICAL & EXPERIMENTAL METASTASIS

Three-dimensional context regulation of metastasis

(2008) Janine T. Erler et al.   CLINICAL & EXPERIMENTAL METASTASIS

LOXL4 is a selectively expressed candidate diagnostic antigen in head and neck cancer

(2008) Jan Bernd Weise et al.   EUROPEAN JOURNAL OF CANCER

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY