Article
Biochemistry & Molecular Biology
Tamara Rosell-Garcia, Sergio Rivas-Munoz, Alain Colige, Fernando Rodriguez-Pascual
Summary: Members of the lysyl oxidase (LOX) family catalyze the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin. Proteolysis by BMP1 and ADAMTS families regulates LOX enzymes, including LOXL1 associated with pelvic organ prolapse and pseudoexfoliation (PEX) glaucoma. This study reveals the molecular information of LOXL1 proteolysis by BMP1 and ADAMTS14, identifying the processing sites and suggesting complex regulation of LOXL1 function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Min Zhang, Shaoyang Sun, Lei Wang, Xu Wang, Tianhui Chen, Zexu Chen, Yongxiang Jiang
Summary: loxl1 deficiency in zebrafish resulted in zonular bundling disorders and accumulation of pearl-like particles in the adult zebrafish eyes. The zonule of loxl1(-/-) zebrafish appeared stretched, ragged, and torn. In addition, thinning or loss of the elastic lamina in Bruch's membrane was observed in the loxl1(+/-) zebrafish.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Alicia De Maria, Keith D. Zientek, Larry L. David, Phillip A. Wilmarth, Anjali M. Bhorade, George J. Harocopos, Andrew J. W. Huang, Augustine R. Hong, Carla J. Siegfried, Linda M. Tsai, Arsham Sheybani, Steven Bassnett
Summary: This study used quantitative mass spectrometry to analyze the composition of XFM in patients with XFS and XFG, revealing a consistent XFM proteome characterized by strong expression of fibrillin-1, lysyl oxidase-like-1, and LEFTY2. The presence of suspected XFM proteins was verified and novel components were identified. Elevated levels of LEFTY2 in the AH of patients with XFG may serve as a biomarker for the disease.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Cell Biology
Elly I. Lewerissa, Nael Nadif Kasri, Katrin Linda
Summary: Autophagy is a crucial metabolic process for maintaining cellular homeostasis and survival. Recent studies have shown the importance of autophagy in brain function, particularly in neuronal development and functioning. Mutations in autophagy-related genes as well as genes involved in epigenetic regulation have been linked to neurodevelopmental disorders (NDDs). This suggests that aberrant autophagic regulation may contribute to nervous system impairments in NDDs with disturbed epigenetic regulation.
Article
Multidisciplinary Sciences
Zintis Inde, Ben A. Croker, Clarence Yapp, Gaurav N. Joshi, Johan Spetz, Cameron Fraser, Xingping Qin, Le Xu, Brian Deskin, Elisa Ghelfi, Gabrielle Webb, Aaron F. Carlin, Yanfang Peipei Zhu, Sandra L. Leibel, Aaron F. Garretson, Alex E. Clark, Jason M. Duran, Victor Pretorius, Laura E. Crotty-Alexander, Chendi Li, Jamie Casey Lee, Chhinder Sodhi, David J. Hackam, Xin Sun, Aaron N. Hata, Lester Kobzik, Jeffrey Miller, Jin-Ah Park, Douglas Brownfield, Hongpeng Jia, Kristopher A. Sarosiek
Summary: The severity of novel coronavirus disease 2019 (COVID-19) varies greatly, with pediatric patients typically experiencing less severe infection than adults and the elderly. This difference may be attributed to an increase in ACE2 expression in lung epithelial cells with advancing age and the more active apoptotic defense system in younger individuals.
Review
Cell Biology
Sara S. Procknow, Beth A. Kozel
Summary: Elastin provides elasticity to tissues such as the lung, blood vessels, and skin, but the mechanisms regulating its production are not fully understood. Studying the expression of the ELN gene may help intervene in rare diseases and potentially replace age-related losses by re-initiating elastin production.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Florencia Mammarella, Leandro Lucero, Nosheen Hussain, Aitor Munoz-Lopez, Ying Huang, Lucia Ferrero, Guadalupe L. Fernandez-Milmanda, Pablo Manavella, Moussa Benhamed, Martin Crespi, Carlos L. Ballare, Jose Gutierrez Marcos, Pilar Cubas, Federico Ariel
Summary: The long noncoding RNA APOLO regulates the shade avoidance syndrome in Arabidopsis thaliana by dynamically modulating expression of key factors. APOLO deregulation leads to the repression of the BRC1 gene and an increase in shoot branching. It also plays a role in leaf hyponasty and influences auxin homeostasis by modulating auxin synthesis and efflux genes.
Article
Genetics & Heredity
Gabriele Zukauskaite, Ingrida Domarkiene, Ausra Matuleviciene, Evelina Marija Vaiteniene, Justas Arasimavicius, Giedre Smailyte, Vaidutis Kucinskas, Laima Ambrozaityte
Summary: This study investigated a unique protective genomic variation in a relatively healthy group of Lithuanian clean-up workers of the Chernobyl nuclear disaster, which may influence individual reaction to ionising radiation and potentially protect against certain diseases. The identification of this protective genomic variant may offer insights into the genetic architecture and etiopathogenetic mechanisms of other multifactorial diseases.
Article
Agronomy
Qianlin Xiao, Yayun Wang, Hui Li, Chunxia Zhang, Bin Wei, Yongbin Wang, Huanhuan Huang, Yangping Li, Guowu Yu, Hanmei Liu, Junjie Zhang, Yinghong Liu, Yufeng Hu, Yubi Huang
Summary: ZmNAC126, a transcription factor in maize, plays a crucial role in regulating starch synthesis and is closely associated with the expression of starch synthesis-related genes.
Article
Biochemistry & Molecular Biology
Anna Pawlik, Beata Ciolek, Justyna Sulej, Andrzej Mazur, Przemyslaw Grela, Magdalena Staszczak, Mateusz Niscior, Magdalena Jaszek, Anna Matuszewska, Grzegorz Janusz, Andrzej Paszczynski
Summary: The study found that laccases released by Cerrena unicolor are regulated at transcriptional, translational, and post-translational steps of gene expression, helping the fungus adapt to environmental changes.
Article
Cardiac & Cardiovascular Systems
Redouane Aherrahrou, Dillon Lue, R. Noah Perry, Yonathan Tamrat Aberra, Mohammad Daud Khan, Joon Yuhl Soh, Tiit Ord, Prosanta Singha, Qianyi Yang, Huda Gilani, Ernest Diez Benavente, Doris Wong, Jameson Hinkle, Lijiang Ma, Gloria M. Sheynkman, Hester M. den Ruijter, Clint L. Miller, Johan L. M. Bjoerkegren, Minna U. Kaikkonen, Mete Civelek
Summary: Coronary artery disease (CAD) is the leading cause of death globally. This study identified over 175 loci associated with CAD and found that they regulate gene expression in vascular smooth muscle cells (SMCs). The results also showed unique gene expression patterns in SMCs and sex-specific gene regulation. These findings provide insights into the molecular mechanisms underlying genetic susceptibility to CAD.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
He Li, Kaifang Guan, DanDan Liu, Min Liu
Summary: This study investigated key differentially expressed genes (DEGs) and pathways associated with the progression of sarcopenia. Through bioinformatics analysis and in vitro myoblast experiment, 10 hub genes have been identified to play a crucial role in regulating aging-related sarcopenia development.
Article
Immunology
Yanwei Cheng, Lijun Xu, Jiaoyang Wang, Xue Cao, Dong Chen, Peirong Zhang, Lei Yang, Lijie Qin
Summary: This study analyzed the transcriptome sequencing data from infected and sepsis patients, and identified key long non-coding RNAs (lncRNAs) and their potential target genes associated with the changes in immune cell proportions. The expression of these lncRNAs and target genes were validated in sepsis patients. The results highlight the important role of lncRNAs in immune cell proportion changes and provide new insight for the study of biomarkers and therapeutic targets in sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anne Nitsche, Christian Arnold, Uwe Ueberham, Kristin Reiche, Joerg Fallmann, Joerg Hackermueller, Friedemann Horn, Peter F. Stadler, Thomas Arendt
Summary: Alzheimer's disease is a neurodegenerative disorder that predominantly affects elderly humans, with little occurrence in non-primate mammals and non-human primates. Research shows that most AD-associated genes have ancient evolutionary origins, but exhibit faster gene structure evolution in loci with AD-related expression changes. Particularly, non-coding genes associated with AD play a significant role in the disease.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Karen R. Mifsud, Clare L. M. Kennedy, Silvia Salatino, Eshita Sharma, Emily M. Price, Samantha N. Haque, Andriana Gialeli, Hannah M. Goss, Polina E. Panchenko, John Broxholme, Simon Engledow, Helen Lockstone, Oscar Cordero Llana, Johannes M. H. M. Reul
Summary: GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to impact gene regulatory programs related to neuronal plasticity, ciliogenesis, and behavioral adaptation. The receptors MR and GR regulate genes involved in synaptic/neuro-plasticity, cell morphology and development, behavior, and neuropsychiatric disorders. These findings suggest a crucial role of GCs in maintaining brain health and adapting to changing environments.
NATURE COMMUNICATIONS
(2021)
