Article
Engineering, Biomedical
Madison E. Bates, Leia Troop, M. Ethan Brown, Jennifer L. Puetzer
Summary: The application of exogenous LOX protein significantly improves the mechanical performance of tissue engineered constructs, with timing of application being crucial. This study provides insights into the cellular regulation of LOX crosslinking.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Nataliya Migulina, Gavin Tjin, Alen Faiz, Theo Borghuis, Fenghua Zhao, Hans J. Kaper, Marit Metzlar, Eline van Dijk, Prashant K. Sharma, Wim Timens, Reinoud Gosens, Corry-Anke Brandsma, Janette K. Burgess
Summary: This study investigated the effects of smoking and COPD on LOs gene and protein expression in the airways and found that LOs alterations may be related to smoking and contribute to impaired airway function in COPD, providing potential novel targets for prevention or treatment of small airways changes in COPD.
Article
Orthopedics
Phong K. K. Nguyen, Kaitlyn Hall, Iverson Holt, Catherine K. K. Kuo
Summary: This study suggests that treatment with recombinant LOX (rLOX) has minimal effects on the morphology and behaviors of developing tendon cells. This indicates that future rLOX-based therapeutic strategies can enhance tendon mechanical properties without adverse effects on tendon cell morphology and behaviors.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Materials Science, Biomaterials
Ramesh Subbiah, Gabriela de Souza Balbinot, Avathamsa Athirasala, Fabricio Mezzomo Collares, Grigoriy Sereda, Luiz E. Bertassoni
Summary: Traditional biomaterials for bone regeneration lack the ability to fully replicate the native bone microenvironment, but a novel approach involving biomimetic mineralization using GelMA hydrogels and calcium citrate core-shell microparticles shows promising results in promoting osteogenic differentiation for bone regeneration. This method successfully achieves biomineralization of the scaffolds, resembling the mineral chemistry, structure, and organization of native bone, ultimately enhancing the potential for bone regeneration efforts.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Hagar Grunwald, Kristina L. Hunker, Isabelle Birt, Rohtem Aviram, Shelly Zaffryar-Eilot, Santhi K. Ganesh, Peleg Hasson
Summary: The interaction between VEGF, TGF beta, and LOX is crucial for the formation of mature vascular smooth muscle cells-coated vessels. Additionally, RNA sequencing analysis identified an interaction with the endothelin-1 pathway.
Article
Multidisciplinary Sciences
Slobodan Vukicevic, Andrea Colliva, Vera Kufner, Valentina Martinelli, Silvia Moimas, Simone Vodret, Viktorija Rumenovic, Milan Milosevic, Boris Brkljacic, Diana Delic-Brkljacic, Ricardo Correa, Mauro Giacca, Manuel Maglione, Tatjana Bordukalo-Niksic, Ivo Dumic-Cule, Serena Zacchigna
Summary: This study demonstrates that the inhibition of the specific isoform of Bone Morphogenetic Protein 1 (BMP1.3) by a monoclonal antibody can reduce cardiac fibrosis and provide cardioprotection through inhibiting the Transforming Growth Factor beta pathway and inducing BMP5. It suggests the therapeutic potential of anti-BMP1.3 antibodies in preventing cardiomyocyte apoptosis, reducing collagen deposition, and preserving cardiac function after ischemia.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Baoyu Li, Xuehong Xian, Xinwei Lin, Luo Huang, Ailin Liang, Hongwei Jiang, Qimei Gong
Summary: Hypoxia enhances the angiogenic potential of dental pulp stem cell exosomes (Exos) and partially alters their proteome profile. Lysyl oxidase-like 2 (LOXL2) is likely involved in hypoxia-preconditioned DPSC-Exos mediated angiogenesis.
Article
Materials Science, Multidisciplinary
Yi Shan, Nilofer Sayed, Kok Chan Chong, Hui Jun Ting, Xianglong Liu, Bowen Li, Jingjing Liu, Min Wu, Jiong-Wei Wang, Bin Liu
Summary: Nonalcoholic steatohepatitis (NASH) is a common disease worldwide, with potential progression to fibrosis, cirrhosis, and hepatocellular carcinoma. This study developed an activatable imaging probe TPAH to monitor fibrosis progression in NASH, showing promising specificity.
ACS MATERIALS LETTERS
(2023)
Article
Multidisciplinary Sciences
Stephanie Smith-Berdan, Alyssa Bercasio, Leah Kramer, Bryan Petkus, Lindsay Hinck, E. Camilla Forsberg
Summary: The study demonstrates the significant role of endothelial Robo4 in directional HSC trafficking, independent of alterations in VEC numbers and VCAM1 expression.
Article
Biochemistry & Molecular Biology
Qiuchen Guo, Duanchen Sun, Alexander S. Barrett, Sonali Jindal, Nathan D. Pennock, Matthew W. Conklin, Zheng Xia, Elizabeth Mitchell, Ravikant Samatham, Naomi Mirza, Steven Jacques, Sheila Weinmann, Virginia F. Borges, Kirk C. Hansen, Pepper J. Schedin
Summary: Mammographically-detected breast density has an impact on breast cancer risk and progression, and the presence of fibrillar collagen plays a crucial role in breast density. This study investigated the physiological factors influencing collagen production in the breast. Through the analysis of gene expression in female rats, the study revealed a triphasic pattern of collagen gene regulation and reproductive state-dependent composition. The findings were confirmed in human breast tissue from premenopausal women. The study also found a correlation between the collagen gene signature and poor progression-free survival in breast cancer patients. These findings contribute to a better understanding of normal breast function, the etiology of breast density, and breast cancer risk and outcomes.
Article
Immunology
Nan Che, Xiaoxuan Sun, Lei Gu, Xiaohui Wang, Jingjing Shi, Yi Sun, Lingxiao Xu, Rui Liu, Junke Wang, Fengyi Zhu, Na Peng, Fan Xiao, Dajun Hu, Liwei Lu, Wen Qiu, Miaojia Zhang
Summary: In rheumatoid arthritis, adiponectin exacerbates the disease by enhancing B cell proliferation and differentiation through the PI3K/Akt1/STAT3 axis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Guillermo A. Martinez-Nieto, Hanna-Riikka Teppo, Noora Petrelius, Valerio Izzi, Raman Devarajan, Tiina Petaisto, Hengshuo Liu, Kris S. Kim, Sanna-Maria Karppinen, Heli Ruotsalainen, Jarkko Koivunen, Joni M. Maki, Gilbert C. Walker, Taina Pihlajaniemi, Donald Gullberg, Ritva Heljasvaara
Summary: Integrin alpha 11 beta 1 is upregulated in human and mouse skin tumors, particularly in high-grade tumors. Deficiency of alpha 11 reduces tumor cell proliferation and tumor burden, but results in the presence of thick and regularly aligned collagen bundles in tumors. This study reveals the role of alpha 11 beta 1 in skin tumorigenesis and highlights the need for further research to understand its molecular mechanisms.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carolina Anazco, Janin Riedelsberger, Lorenzo Vega-Montoto, Armando Rojas
Summary: Collagen is a vital structural protein in mammals and is strengthened by complex enzymatic and non-enzymatic reactions, such as covalent cross-linking and glycation. This review article explores the amine oxidase-like activity of plant polyphenols and their potential as antiglycation agents. It also discusses the molecular mechanisms by which specific flavonoids impact or protect the normal collagen cross-linking process, with the aim of promoting the stabilization of highly organized collagen fibrils.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Philip C. Trackman, Yaser Peymanfar, Sayon Roy
Summary: Lysyl oxidases are multifunctional proteins involved in the biosynthesis and maturation of connective tissues. Their overexpression is associated with fibrosis and cancer, while their propeptide has tumor-suppressing effects. In diabetic retinopathy, lysyl oxidases are overexpressed and their propeptide levels are elevated. Further research is needed to understand the activities and mechanisms of lysyl oxidase propeptide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Aniqa Chowdhury, Nasim Nosoudi, Saketh Karamched, Vaideesh Parasaram, Naren Vyavahare
Summary: The combination of polyphenols with short exposure to UVA light can increase extracellular matrix deposition of elastin and collagen, potentially improving skin properties.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Review
Cell Biology
Philip C. Trackman
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2018)
Article
Oncology
Ana de la Cueva, Michael Emmerling, Sarah L. Lim, Shi Yang, Philip C. Trackman, Gail E. Sonenshein, Kathrin H. Kirsch
Article
Dentistry, Oral Surgery & Medicine
D. Saxena, F. Mahjour, A. D. Findlay, E. A. Mously, A. Kantarci, P. C. Trackman
JOURNAL OF DENTAL RESEARCH
(2018)
Article
Dentistry, Oral Surgery & Medicine
C. R. Herzog, D. W. Berzins, P. DenBesten, R. L. Gregory, K. M. Hargreaves, R. L. W. Messer, M. Mina, M. P. Mooney, M. L. Paine, C. Phillips, R. B. Presland, R. G. Quivey, F. A. Scannapieco, J. F. Sheridan, K. K. H. Svoboda, P. C. Trackman, M. P. Walker, S. G. Walker, C. Y. Wang, J. C. C. Hu
JOURNAL OF DENTAL RESEARCH
(2018)
Meeting Abstract
Oncology
Faranak Mahjour, Philip C. Trackman
Article
Oncology
Faranak Mahjour, Vrinda Dambal, Neha Shrestha, Varun Singh, Vikki Noonan, Alpdogan Kantarci, Philip C. Trackman
Article
Pathology
Dongjoon Kim, Dayeun Lee, Philip C. Trackman, Sayon Roy
AMERICAN JOURNAL OF PATHOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Philip C. Trackman, Yaser Peymanfar, Sayon Roy
Summary: Lysyl oxidases are multifunctional proteins involved in the biosynthesis and maturation of connective tissues. Their overexpression is associated with fibrosis and cancer, while their propeptide has tumor-suppressing effects. In diabetic retinopathy, lysyl oxidases are overexpressed and their propeptide levels are elevated. Further research is needed to understand the activities and mechanisms of lysyl oxidase propeptide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yaser Peymanfar, Faranak Mahjour, Neha Shrestha, Ana de la Cueva, Ying Chen, Shengyuan Huang, Kathrin H. Kirsch, Xiaozhe Han, Philip C. Trackman
Summary: Oral cancer, primarily squamous-cell carcinoma with a 5-year survival rate of approximately 50%, is more common in humans carrying a polymorphism in the propeptide region of lysyl oxidase (LOX). Knockin mice carrying the same polymorphism are more susceptible to lesion development. The presence of wildtype LOX-PP in humans and mice has a tumor-inhibitory effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Philip C. C. Trackman
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Eileen J. Daley, Philip C. Trackman
Summary: This study reveals the mechanism by which GIP regulates LOX expression, mediated by beta-catenin. These findings provide important insights for designing potential therapeutic approaches to address deficient LOX production in diabetic bone disease by suggesting exploring strategies to stimulate beta-catenin signaling in osteoblasts under diabetic conditions as potential therapeutic strategies.
Meeting Abstract
Ophthalmology
Ngan Ha Nguyen, Dongjoon Kim, Philip C. Trackman, Sayon Roy
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Endocrinology & Metabolism
Eileen J. Daley, Paola Divieti Pajevic, Sayon Roy, Philip C. Trackman
Article
Medicine, Research & Experimental
Vivian S. Lee, Carmen M. Halabi, Thomas J. Broekelmann, Philip C. Trackman, Nathan O. Stitziel, Robert P. Mecham
Article
Ophthalmology
Dongjoon Kim, Robert P. Mecham, Philip C. Trackman, Sayon Roy
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)