G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets

DNA polymerases in the mitochondria A critical review of the evidence

(2017) William C Copeland   Frontiers in Bioscience-Landmark

Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment

(2017) Erica Salvati et al.   JOURNAL OF MEDICINAL CHEMISTRY

RNA G-Quadruplexes in Biology: Principles and Molecular Mechanisms

(2017) Marta M. Fay et al.   JOURNAL OF MOLECULAR BIOLOGY

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

(2017) Robert Hänsel-Hertsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular basis for PrimPol recruitment to replication forks by RPA

(2017) Thomas A. Guilliam et al.   Nature Communications

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair

(2017) Kelly Beagan et al.   PLoS Genetics

Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae

(2017) Aurèle Piazza et al.   eLife

PrimPol—Prime Time to Reprime

(2017) Thomas Guilliam et al.   Genes

Human PrimPol activity is enhanced by RPA

(2017) María I. Martínez-Jiménez et al.   Scientific Reports

Erratum: Corrigendum: The human mitochondrial transcription factor A is a versatile G-quadruplex binding protein

(2017) Sébastien Lyonnais et al.   Scientific Reports

Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA

(2016) Sarah Eddy et al.   BIOCHEMISTRY

Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

(2016) Kaori Kobayashi et al.   CELL CYCLE

Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1

(2016) Mina Yeom et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Getting it done at the ends: Pif1 family DNA helicases and telomeres

(2016) Carly L. Geronimo et al.   DNA REPAIR

The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription

(2016) Weiliang Tang et al.   HUMAN MOLECULAR GENETICS

PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells

(2016) Davide Schiavone et al.   MOLECULAR CELL

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

(2016) Jutta Zimmer et al.   MOLECULAR CELL

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

G-quadruplexes and helicases

(2016) Oscar Mendoza et al.   NUCLEIC ACIDS RESEARCH

Quantitative analysis and prediction of G-quadruplex forming sequences in double-stranded DNA

(2016) Minji Kim et al.   NUCLEIC ACIDS RESEARCH

Re-evaluation of G-quadruplex propensity with G4Hunter

(2016) Amina Bedrat et al.   NUCLEIC ACIDS RESEARCH

G4IPDB: A database for G-quadruplex structure forming nucleic acid interacting proteins

(2016) Subodh Kumar Mishra et al.   Scientific Reports

Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles

(2016) Sanjay Bharti et al.   Genes

A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy

(2016) Wenpeng Liu et al.   EBioMedicine

Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA

(2015) Sarah Eddy et al.   BIOCHEMISTRY

Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription

(2015) John A. Smestad et al.   BMC Medical Genetics

PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage

(2015) Laura J. Bailey et al.   CELL CYCLE

Contributions of the specialised DNA polymerases to replication of structured DNA

(2015) Caroline M. Wickramasinghe et al.   DNA REPAIR

G4-associated human diseases

(2015) N. Maizels   EMBO REPORTS

Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies

(2015) Jordi Carreras Puigvert et al.   FEBS Journal

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

(2015) William C. Drosopoulos et al.   JOURNAL OF CELL BIOLOGY

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

(2015) Joseph A. Newman et al.   STRUCTURE

Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers

(2015) Bennie Lemmens et al.   Nature Communications

Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints

(2014) Dawei W Dong et al.   BMC GENOMICS

Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion

(2014) Xiao Ling Li et al.   CELL CYCLE

Metabolism of DNA secondary structures at the eukaryotic replication fork

(2014) Ana María León-Ortiz et al.   DNA REPAIR

Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability

(2014) Guliang Wang et al.   DNA REPAIR

FANCJ promotes DNA synthesis through G-quadruplex structures

(2014) P. Castillo Bosch et al.   EMBO JOURNAL

DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase

(2014) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

(2014) Lucas T Gray et al.   Nature Chemical Biology

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

(2014) Giang Huong Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

(2014) Wouter Koole et al.   Nature Communications

Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

(2013) M. Aggarwal et al.   CANCER RESEARCH

A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

(2013) Giang Huong Nguyen et al.   CHEMISTRY & BIOLOGY

Impediments to replication fork movement: stabilisation, reactivation and genome instability

(2013) Sarah Lambert et al.   CHROMOSOMA

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

(2013) Weiqiang Lin et al.   EMBO JOURNAL

Exome sequencing reveals CCDC111 mutation associated with high myopia

(2013) Fuxin Zhao et al.   HUMAN GENETICS

Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability

(2013) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Origin Recognition Complex Binds Preferentially to G-quadruplex-preferable RNA and Single-stranded DNA

(2013) Shoko Hoshina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ couples replication past natural fork barriers with maintenance of chromatin structure

(2013) Rebekka A. Schwab et al.   JOURNAL OF CELL BIOLOGY

PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication

(2013) Julie Bianchi et al.   MOLECULAR CELL

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

(2013) Sara García-Gómez et al.   MOLECULAR CELL

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Repriming of DNA synthesis at stalled replication forks by human PrimPol

(2013) Silvana Mourón et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Rev1 polymerase disrupts G-quadruplex DNA

(2013) S. Eddy et al.   NUCLEIC ACIDS RESEARCH

DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation

(2013) Justin D. Lormand et al.   NUCLEIC ACIDS RESEARCH

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures

(2013) Matthew R. Northam et al.   NUCLEIC ACIDS RESEARCH

RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication

(2013) J.-B. Vannier et al.   SCIENCE

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

Preparation of Site-specific T=mCGcis-synCyclobutane Dimer-containing Template and Its Error-free Bypass by Yeast and Human Polymerase η

(2012) Qian Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs

(2012) Emilie Besnard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

QGRS-H Predictor: a web server for predicting homologous quadruplex forming G-rich sequence motifs in nucleotide sequences

(2012) Camille Menendez et al.   NUCLEIC ACIDS RESEARCH

The Werner Syndrome Protein Is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA Structures

(2012) Ashwini Kamath-Loeb et al.   PLoS One

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

Conformational changes of non-B DNA

(2011) Jungkweon Choi et al.   CHEMICAL SOCIETY REVIEWS

G-quadruplex-induced instability during leading-strand replication

(2011) Judith Lopes et al.   EMBO JOURNAL

Sequential assembly of translesion DNA polymerases at UV-induced DNA damage sites

(2011) Parker L. Andersen et al.   MOLECULAR BIOLOGY OF THE CELL

DNA secondary structures and epigenetic determinants of cancer genome evolution

(2011) Subhajyoti De et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

(2011) M. Aggarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-quadruplex nucleic acids and human disease

(2010) Yuliang Wu et al.   FEBS Journal

Epigenetic Instability due to Defective Replication of Structured DNA

(2010) Peter Sarkies et al.   MOLECULAR CELL

Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae

(2010) Aurèle Piazza et al.   NUCLEIC ACIDS RESEARCH

Predicting and understanding the stability of G-quadruplexes

(2009) Oliver Stegle et al.   BIOINFORMATICS

Non-B DNA structure-induced genetic instability and evolution

(2009) Junhua Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure of the Human Rev1–DNA–dNTP Ternary Complex

(2009) Michael K. Swan et al.   JOURNAL OF MOLECULAR BIOLOGY

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells

(2009) Rémy Bétous et al.   MOLECULAR CARCINOGENESIS

Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

(2009) Jay E. Johnson et al.   NUCLEIC ACIDS RESEARCH

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro

(2008) S. Wanrooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA