The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription

Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription

(2015) John A. Smestad et al.   BMC Medical Genetics

G4-associated human diseases

(2015) N. Maizels   EMBO REPORTS

Beginning at the end: DNA replication within the telomere

(2015) Susan A. Gerbi   JOURNAL OF CELL BIOLOGY

BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

(2015) William C. Drosopoulos et al.   JOURNAL OF CELL BIOLOGY

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Dynamic profiling of the protein life cycle in response to pathogens

(2015) M. Jovanovic et al.   SCIENCE

Human RecQ Helicases in DNA Repair, Recombination, and Replication

(2014) Deborah L. Croteau et al.   Annual Review of Biochemistry

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources

(2014) Gene-Wei Li et al.   CELL

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Existence and consequences of G-quadruplex structures in DNA

(2014) Pierre Murat et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol

(2014) Mathew Sajish et al.   NATURE

G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

(2014) Lucas T Gray et al.   Nature Chemical Biology

Ribosome profiling: new views of translation, from single codons to genome scale

(2014) Nicholas T. Ingolia   NATURE REVIEWS GENETICS

MiR-181 family: regulators of myeloid differentiation and acute myeloid leukemia as well as potential therapeutic targets

(2014) R Su et al.   ONCOGENE

Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture

(2014) Akira Shimamoto et al.   PLoS One

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

(2014) Giang Huong Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of regulatory variation from RNA to protein

(2014) A. Battle et al.   SCIENCE

Human tRNA synthetase catalytic nulls with diverse functions

(2014) W.-S. Lo et al.   SCIENCE

Growing knowledge of the mTOR signaling network

(2014) Kezhen Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Protein mistranslation: friend or foe?

(2014) Liuís Ribas de Pouplana et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

(2014) Christopher F. Bennett et al.   Nature Communications

System wide analyses have underestimated protein abundances and the importance of transcription in mammals

(2014) Jingyi Jessica Li et al.   PeerJ

Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging

(2014) Hoi-Hung Cheung et al.   Stem Cell Reports

Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts

(2013) Bidisha Saha et al.   AGING CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

5′ C-rich telomeric overhangs are an outcome of rapid telomere truncation events

(2013) Liana Oganesian et al.   DNA REPAIR

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential nontranslational functions of tRNA synthetases

(2013) Min Guo et al.   Nature Chemical Biology

Hydrogen sulfide restores a normal morphological phenotype in Werner syndrome fibroblasts, attenuates oxidative damage and modulates mTOR pathway

(2013) F. Talaei et al.   PHARMACOLOGICAL RESEARCH

Spectrum and Risk of Neoplasia in Werner Syndrome: A Systematic Review

(2013) Julia M. Lauper et al.   PLoS One

The G4 Genome

(2013) Nancy Maizels et al.   PLoS Genetics

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences

(2012) Rama Rao Damerla et al.   CELL CYCLE

The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres

(2012) Aaron Mendez-Bermudez et al.   NUCLEIC ACIDS RESEARCH

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Small-Molecule Allosteric Activators of Sirtuins

(2011) David A. Sinclair et al.   Annual Review of Pharmacology and Toxicology

Diagnostic microRNAs in myelodysplastic syndrome

(2011) Begum Erdogan et al.   EXPERIMENTAL HEMATOLOGY

Deep proteome and transcriptome mapping of a human cancer cell line

(2011) N. Nagaraj et al.   Molecular Systems Biology

The quantitative proteome of a human cell line

(2011) M. Beck et al.   Molecular Systems Biology

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome

(2011) Pauline Chabosseau et al.   Nature Communications

Epigenetic Instability due to Defective Replication of Structured DNA

(2010) Peter Sarkies et al.   MOLECULAR CELL

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

The Werner Syndrome Protein Suppresses Telomeric Instability Caused by Chromium (VI) Induced DNA Replication Stress

(2010) Fu-Jun Liu et al.   PLoS One

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

(2009) Jay E. Johnson et al.   NUCLEIC ACIDS RESEARCH

WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2 B-Mediated Telomere Shortening

(2008) B. Li et al.   MOLECULAR AND CELLULAR BIOLOGY