Impediments to replication fork movement: stabilisation, reactivation and genome instability

The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing

(2012) Jiazhi Hu et al.   CELL

Replication stress and mechanisms of CNV formation

(2012) Martin F Arlt et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability

(2012) R. Steinacher et al.   GENES & DEVELOPMENT

DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase

(2012) N. Sabouri et al.   GENES & DEVELOPMENT

Replisome Stability at Defective DNA Replication Forks Is Independent of S Phase Checkpoint Kinases

(2012) Giacomo De Piccoli et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The complex basis underlying common fragile site instability in cancer

(2012) Efrat Ozeri-Galai et al.   TRENDS IN GENETICS

Topoisomerase II– and Condensin-Dependent Breakage of MEC1ATR-Sensitive Fragile Sites Occurs Independently of Spindle Tension, Anaphase, or Cytokinesis

(2012) Nadia Hashash et al.   PLoS Genetics

Helicases that underpin replication of protein-bound DNA inEscherichia coli

(2011) Peter McGlynn   BIOCHEMICAL SOCIETY TRANSACTIONS

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

(2011) Rodrigo Bermejo et al.   CELL

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

DNA polymerases provide a canon of strategies for translesion synthesis past oxidatively generated lesions

(2011) Karl E Zahn et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Brca2, Rad51 and Mre11: Performing balancing acts on replication forks

(2011) Vincenzo Costanzo   DNA REPAIR

G-quadruplex-induced instability during leading-strand replication

(2011) Judith Lopes et al.   EMBO JOURNAL

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles

(2011) Belén Gómez-González et al.   EMBO JOURNAL

Timing and spacing of ubiquitin-dependent DNA damage bypass

(2011) Helle D. Ulrich   FEBS LETTERS

Tight protein-DNA interactions favor gene silencing

(2011) M. Dubarry et al.   GENES & DEVELOPMENT

The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers

(2011) Anne Blumrich et al.   HUMAN MOLECULAR GENETICS

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression

(2011) Tsuyoshi Kawabata et al.   MOLECULAR CELL

Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites

(2011) Efrat Ozeri-Galai et al.   MOLECULAR CELL

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

Molecular profiling of common fragile sites in human fibroblasts

(2011) Benoî Le Tallec et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier

(2011) Sevil Sofueva et al.   NUCLEIC ACIDS RESEARCH

The Escherichia coli Replisome Is Inherently DNA Damage Tolerant

(2011) J. T. P. Yeeles et al.   SCIENCE

Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair

(2011) D. T. Long et al.   SCIENCE

Common fragile sites: mechanisms of instability revisited

(2011) Michelle Debatisse et al.   TRENDS IN GENETICS

Breakages at common fragile sites set boundaries of amplified regions in two leukemia cell lines K562 – Molecular characterization of FRA2H and localization of a new CFS FRA2S

(2010) Franca Pelliccia et al.   CANCER LETTERS

Regulation of Replication Termination by Reb1 Protein-Mediated Action at a Distance

(2010) Samarendra K. Singh et al.   CELL

What happens when replication and transcription complexes collide?

(2010) Richard T. Pomerantz et al.   CELL CYCLE

Unwinding the functions of the Pif1 family helicases

(2010) Matthew L. Bochman et al.   DNA REPAIR

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

(2010) K. Labib   GENES & DEVELOPMENT

Regulation of fragile sites expression in budding yeast by MEC1, RRM3 and hydroxyurea

(2010) N. Hashash et al.   JOURNAL OF CELL SCIENCE

Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements

(2010) Daniele Fachinetti et al.   MOLECULAR CELL

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

(2010) Sarah Lambert et al.   MOLECULAR CELL

Multiple Rad5 Activities Mediate Sister Chromatid Recombination to Bypass DNA Damage at Stalled Replication Forks

(2010) Eugen C. Minca et al.   MOLECULAR CELL

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

The FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response

(2010) Min Huang et al.   MOLECULAR CELL

Mechanisms of trinucleotide repeat instability during human development

(2010) Cynthia T. McMurray   NATURE REVIEWS GENETICS

Eukaryotic DNA replication origins: many choices for appropriate answers

(2010) Marcel Méchali   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pathways of mammalian replication fork restart

(2010) Eva Petermann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systematic identification of fragile sites via genome-wide location analysis of γ-H2AX

(2010) Rachel K Szilard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad3ATR Decorates Critical Chromosomal Domains with γH2A to Protect Genome Integrity during S-Phase in Fission Yeast

(2010) Sophie Rozenzhak et al.   PLoS Genetics

Co-Orientation of Replication and Transcription Preserves Genome Integrity

(2010) Anjana Srivatsan et al.   PLoS Genetics

Replicon Dynamics, Dormant Origin Firing, and Terminal Fork Integrity after Double-Strand Break Formation

(2009) Ylli Doksani et al.   CELL

The replication fork's five degrees of freedom, their failure and genome rearrangements

(2009) T Weinert et al.   CURRENT OPINION IN CELL BIOLOGY

The helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo

(2009) Hasna Boubakri et al.   EMBO JOURNAL

Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism

(2009) K. Mizuno et al.   GENES & DEVELOPMENT

Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast

(2009) A. L. Paek et al.   GENES & DEVELOPMENT

Impaired replication dynamics at the FRA3B common fragile site

(2009) Aparna Palakodeti et al.   HUMAN MOLECULAR GENETICS

Common fragile sites are characterized by histone hypoacetylation

(2009) Yanwen Jiang et al.   HUMAN MOLECULAR GENETICS

Fbh1 Limits Rad51-Dependent Recombination at Blocked Replication Forks

(2009) A. Lorenz et al.   MOLECULAR AND CELLULAR BIOLOGY

Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces cerevisiae

(2009) Anna Azvolinsky et al.   MOLECULAR CELL

Large-Scale Expansions of Friedreich's Ataxia GAA Repeats in Yeast

(2009) Alexander A. Shishkin et al.   MOLECULAR CELL

Mechanisms of polar arrest of a replication fork

(2009) Daniel L. Kaplan et al.   MOLECULAR MICROBIOLOGY

Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1

(2009) D. W. Pryce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart

(2009) T. Inagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

Mechanisms of Dealing with DNA Damage-Induced Replication Problems

(2008) Magda Budzowska et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Multiple pathways cooperate to facilitate DNA replication fork progression through alkylated DNA

(2008) M VAZQUEZ et al.   DNA REPAIR

Replication fork arrest, recombination and the maintenance of ribosomal DNA stability

(2008) E TSANG et al.   DNA REPAIR

Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair

(2008) Hyun-Min Kim et al.   EMBO JOURNAL

Mus81 is essential for sister chromatid recombination at broken replication forks

(2008) Laura Roseaulin et al.   EMBO JOURNAL

DNA triplexes and Friedreich ataxia

(2008) Robert D. Wells   FASEB JOURNAL

Rtf1-Mediated Eukaryotic Site-Specific Replication Termination

(2008) T. Eydmann et al.   GENETICS

Comparative Genomics and Molecular Dynamics of DNA Repeats in Eukaryotes

(2008) G.-F. Richard et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mechanistic Insights into Replication Termination as Revealed by Investigations of the Reb1-Ter3 Complex of Schizosaccharomyces pombe

(2008) S. Biswas et al.   MOLECULAR AND CELLULAR BIOLOGY

The FANCM Ortholog Fml1 Promotes Recombination at Stalled Replication Forks and Limits Crossing Over during DNA Double-Strand Break Repair

(2008) Weili Sun et al.   MOLECULAR CELL

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

Stochastic hybrid modeling of DNA replication across a complete genome

(2008) J. Lygeros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins

(2008) I. Voineagu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA