Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion

G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

(2014) Lucas T Gray et al.   Nature Chemical Biology

A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis

(2014) M Subramanian et al.   ONCOGENE

DNA Damage Response Genes and the Development of Cancer Metastasis

(2014) Constantinos G. Broustas et al.   RADIATION RESEARCH

Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers

(2014) Victoria Valinluck Lao et al.   Translational Oncology

Early replication fragile sites: where replication–transcription collisions cause genetic instability

(2013) Oliver Mortusewicz et al.   EMBO JOURNAL

A p21-ZEB1 Complex Inhibits Epithelial-Mesenchymal Transition through the MicroRNA 183-96-182 Cluster

(2013) X. L. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D

(2013) Xing Lu et al.   Molecular Cancer

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

(2013) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks

(2013) Swetha Parvathaneni et al.   PLoS One

RECQL1 DNA Repair Helicase: A Potential Therapeutic Target and a Proliferative Marker against Ovarian Cancer

(2013) Sakiko Sanada et al.   PLoS One

Checkpoint Kinases Regulate a Global Network of Transcription Factors in Response to DNA Damage

(2013) Eric J. Jaehnig et al.   Cell Reports

The G4 Genome

(2013) Nancy Maizels et al.   PLoS Genetics

Cyclin-dependent kinase 4/6 inhibition in cancer therapy

(2012) Neil Johnson et al.   CELL CYCLE

Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors

(2012) Jeffry L. Dean et al.   CELL CYCLE

RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures

(2012) Venkateswarlu Popuri et al.   CELL CYCLE

RECQ1 plays a distinct role in cellular response to oxidative DNA damage

(2012) Sudha Sharma et al.   DNA REPAIR

Transcription directed by human core promoters with a HomolD box sequence requires DDB1, RECQL and RNA polymerase II machinery

(2012) Juan Contreras-Levicoy et al.   GENE

Rad9 Protein Contributes to Prostate Tumor Progression by Promoting Cell Migration and Anoikis Resistance

(2012) Constantinos G. Broustas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Gene Expression-Based Score to Predict Sensitivity of Multiple Myeloma Cells to DNA Methylation Inhibitors

(2012) J. Moreaux et al.   MOLECULAR CANCER THERAPEUTICS

DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks

(2012) Tibor Pankotai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of chromatin structure by poly(ADP-ribosyl)ation

(2012) Sascha Beneke   Frontiers in Genetics

RECQL1 and WRN Proteins Are Potential Therapeutic Targets in Head and Neck Squamous Cell Carcinoma

(2011) A. Arai et al.   CANCER RESEARCH

Unique and important consequences of RECQ1 deficiency in mammalian cells

(2011) Sudha Sharma et al.   CELL CYCLE

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses

(2011) Ramachander V.N. Turaga et al.   CELL CYCLE

BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription

(2011) Patrick M. Grierson et al.   HUMAN MOLECULAR GENETICS

The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation

(2011) Ramiro Mendoza-Maldonado et al.   Molecular Cancer

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

The Effect of a DNA Repair Gene on Cellular Invasiveness: Xrcc3 Over-Expression in Breast Cancer Cells

(2011) Veronica L. Martinez-Marignac et al.   PLoS One

Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide

(2010) Adam Labbé et al.   BMC GENOMICS

Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis

(2010) Y. Su et al.   CANCER RESEARCH

High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcome

(2010) Raffaela Barbano et al.   INTERNATIONAL JOURNAL OF CANCER

TheKRASPromoter Responds to Myc-associated Zinc Finger and Poly(ADP-ribose) Polymerase 1 Proteins, Which Recognize a Critical Quadruplex-formingGA-element

(2010) Susanna Cogoi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human RECQ1 and RECQ4 Helicases Play Distinct Roles in DNA Replication Initiation

(2010) S. Thangavel et al.   MOLECULAR AND CELLULAR BIOLOGY

Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma

(2010) Ronald T. Cotton et al.   HPB

Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver

(2009) Antoine Amaury Lachaud et al.   BIOCHEMICAL PHARMACOLOGY

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Proteomic and targeted analytical identification of BXDC1 and EBNA1BP2 as dynamic scaffold proteins in the nucleolus

(2009) Yasuhiro Hirano et al.   GENES TO CELLS

Direct and indirect roles of RECQL4 in modulating base excision repair capacity

(2009) Shepherd H. Schurman et al.   HUMAN MOLECULAR GENETICS

Direct Inhibition of RNA Polymerase II Transcription by RECQL5

(2009) Ozan Aygün et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Topoisomerase I and RecQL1 Function in Epstein-Barr Virus Lytic Reactivation

(2009) P. Wang et al.   JOURNAL OF VIROLOGY

Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

(2009) Jay E. Johnson et al.   NUCLEIC ACIDS RESEARCH

Association of human DNA helicase RecQ5β with RNA polymerase II and its possible role in transcription

(2008) Keiichi Izumikawa et al.   BIOCHEMICAL JOURNAL

Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models

(2008) Kazunobu Futami et al.   CANCER SCIENCE

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

(2008) W Lee Kraus   CURRENT OPINION IN CELL BIOLOGY

The transcriptional response to distinct growth factors is impaired in Werner syndrome cells

(2008) Anna Lutomska et al.   EXPERIMENTAL GERONTOLOGY

The Human RecQ Helicases, BLM and RECQ1, Display Distinct DNA Substrate Specificities

(2008) Venkateswarlu Popuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of DNA repair genes is associated with metastasis: A new hypothesis

(2008) A SARASIN et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression

(2008) Ram Krishna Thakur et al.   NUCLEIC ACIDS RESEARCH

A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin

(2008) O. Aygun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA