Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

Cytotoxic and genotoxic profiles of benzo[a]pyrene and N-nitrosodimethylamine demonstrated using DNA repair deficient DT40 cells with metabolic activation

(2016) Masato Ooka et al.   CHEMOSPHERE

PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells

(2016) Davide Schiavone et al.   MOLECULAR CELL

Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease

(2016) Junpei Yamamoto et al.   MOLECULES

PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage

(2015) Laura J. Bailey et al.   CELL CYCLE

Clinical Events After Cessation of Lamivudine Therapy in Patients Recovered From Hepatitis B Flare With Hepatic Decompensation

(2015) Ming-Ling Chang et al.   Clinical Gastroenterology and Hepatology

Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol

(2015) María I. Martínez-Jiménez et al.   DNA REPAIR

Author Response: PRIMPOL Mutation: Functional Study Does Not Always Reveal the Truth

(2015) B. A. Keen et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

PRIMPOL Mutation: Functional Study Does Not Always Reveal the Truth

(2015) J. Li et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes

(2015) Thomas A. Guilliam et al.   NUCLEIC ACIDS RESEARCH

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ

(2015) Kouji Hirota et al.   NUCLEIC ACIDS RESEARCH

Distinct DNA Damage Spectra Induced by Ionizing Radiation in Normoxic and Hypoxic Cells

(2015) Naoto Shimizu et al.   RADIATION RESEARCH

Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia

(2015) K. Tada et al.   Science Advances

Molecular dissection of the domain architecture and catalytic activities of human PrimPol

(2014) Benjamin A. Keen et al.   NUCLEIC ACIDS RESEARCH

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

(2014) Thomas A. Guilliam et al.   NUCLEIC ACIDS RESEARCH

Human PrimPol mutation associated with high myopia has a DNA replication defect

(2014) Benjamin A. Keen et al.   NUCLEIC ACIDS RESEARCH

Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining

(2014) S Kobayashi et al.   ONCOGENE

Human Pol   purified with accessory subunits is active in translesion DNA synthesis and complements Pol   in cisplatin bypass

(2014) Y.-S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Specific Endonucleases Xpf and Mus81 Play Overlapping but Essential Roles in DNA Repair by Homologous Recombination

(2013) K. Kikuchi et al.   CANCER RESEARCH

hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity

(2013) Li Wan et al.   EMBO REPORTS

Exome sequencing reveals CCDC111 mutation associated with high myopia

(2013) Fuxin Zhao et al.   HUMAN GENETICS

PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication

(2013) Julie Bianchi et al.   MOLECULAR CELL

PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome

(2013) Sean G. Rudd et al.   MOLECULAR CELL

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

(2013) Sara García-Gómez et al.   MOLECULAR CELL

Repriming of DNA synthesis at stalled replication forks by human PrimPol

(2013) Silvana Mourón et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks

(2013) Mari Fujita et al.   PLoS One

Translesion DNA Synthesis and Mutagenesis in Eukaryotes

(2013) J. E. Sale   Cold Spring Harbor Perspectives in Biology

Competition, collaboration and coordination - determining how cells bypass DNA damage

(2012) J. E. Sale   JOURNAL OF CELL SCIENCE

Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines

(2011) Kimiyo N. Yamamoto et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression

(2011) Tsuyoshi Kawabata et al.   MOLECULAR CELL

Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

(2011) K. N. Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Escherichia coli Replisome Is Inherently DNA Damage Tolerant

(2011) J. T. P. Yeeles et al.   SCIENCE

DNA polymerases ν and θ are required for efficient immunoglobulin V gene diversification in chicken

(2010) Masaoki Kohzaki et al.   JOURNAL OF CELL BIOLOGY

Structure and mechanism of human DNA polymerase η

(2010) Christian Biertümpfel et al.   NATURE

Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions

(2010) Kouji Hirota et al.   PLoS Genetics

Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes

(2009) Makoto Nakahara et al.   PLoS Genetics

DNA Polymerases as Therapeutic Targets†

(2008) Anthony J. Berdis   BIOCHEMISTRY

Homologous recombination in DNA repair and DNA damage tolerance

(2008) Xuan Li et al.   CELL RESEARCH

The 9-1-1 DNA Clamp Is Required for Immunoglobulin Gene Conversion

(2008) A. Saberi et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

(2008) Arkaitz Ibarra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA