Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
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Title
Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-06-06
DOI
10.3389/fimmu.2019.00925
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Note: Only part of the references are listed.- Safety and Tolerability of Adoptive Cell Therapy in Cancer
- (2019) Benita Wolf et al. DRUG SAFETY
- Consensus guidelines for the use and interpretation of angiogenesis assays
- (2018) Patrycja Nowak-Sliwinska et al. ANGIOGENESIS
- Comprehensive evaluation of NT5E/CD73 expression and its prognostic significance in distinct types of cancers
- (2018) Tao Jiang et al. BMC CANCER
- Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models
- (2018) Robert D. Leone et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer
- (2018) Lifeng Li et al. CANCER RESEARCH
- Autocrine Adenosine regulates tumor polyfunctional CD73+CD4+ effector T cells devoid of immune checkpoints
- (2018) Nicolas Gourdin et al. CANCER RESEARCH
- AB928, a dual antagonist of the A 2a R and A 2b R adenosine receptors, leads to greater immune activation and reduced tumor growth when combined with chemotherapy
- (2018) U. Schindler et al. EUROPEAN JOURNAL OF CANCER
- The Inside Story of Adenosine
- (2018) Marcella Camici et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A2AAdenosine Receptor Gene Deletion or Synthetic A2AAntagonist Liberate Tumor-Reactive CD8+T Cells from Tumor-Induced Immunosuppression
- (2018) Jorgen Kjaergaard et al. JOURNAL OF IMMUNOLOGY
- Extracellular adenosine produced by ecto-5′-nucleotidase (CD73) regulates macrophage pro-inflammatory responses, nitric oxide production, and favors Salmonella persistence
- (2018) Matthew G. Costales et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Chemotherapy induces enrichment of CD47+/CD73+/PDL1+immune evasive triple-negative breast cancer cells
- (2018) Debangshu Samanta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging
- (2018) Eduardo N. Chini et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- CD38-mediated immunosuppression as a mechanism of tumor cell escape from PD-1/PD-L1 blockade
- (2018) Limo Chen et al. Cancer Discovery
- CD73 expression and clinical significance in human metastatic melanoma
- (2018) Inês Monteiro et al. Oncotarget
- Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors
- (2018) Sonja Hinz et al. Oncotarget
- Emerging Roles of Nucleoside Transporters
- (2018) Marçal Pastor-Anglada et al. Frontiers in Pharmacology
- Who Is Who in Adenosine Transport
- (2018) Marçal Pastor-Anglada et al. Frontiers in Pharmacology
- Targeting adenosine for cancer immunotherapy
- (2018) Robert D. Leone et al. Journal for ImmunoTherapy of Cancer
- Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations
- (2018) Judith A. Seidel et al. Frontiers in Oncology
- Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
- (2018) Yannick Simoni et al. NATURE
- In Vivo Expansion of Regulatory T Cells with IL-2/IL-2 Antibody Complex Protects against Transient Ischemic Stroke
- (2018) Haiyue Zhang et al. JOURNAL OF NEUROSCIENCE
- The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets
- (2017) Bertrand Allard et al. IMMUNOLOGICAL REVIEWS
- Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer
- (2017) Mohammad H. Kazemi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
- (2017) Paul A. Beavis et al. JOURNAL OF CLINICAL INVESTIGATION
- cAMP: a multifaceted modulator of immune synapse assembly and T cell activation
- (2017) Vijay Bharathi Arumugham et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Adenosine contribution to normal renal physiology and chronic kidney disease
- (2017) Carlos Oyarzún et al. MOLECULAR ASPECTS OF MEDICINE
- Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma
- (2017) Si-Rui Ma et al. Molecular Cancer
- cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes
- (2017) Timothy B. Johnstone et al. MOLECULAR PHARMACOLOGY
- CBirTox is a selective antigen-specific agonist of the Treg-IgA-microbiota homeostatic pathway
- (2017) Katie L. Alexander et al. PLoS One
- Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure
- (2017) Eunyoung Tak et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Cancer associated fibroblasts: An essential role in the tumor microenvironment
- (2017) Leilei Tao et al. Oncology Letters
- A2B adenosine receptor agonist induces cell cycle arrest and apoptosis in breast cancer stem cells via ERK1/2 phosphorylation
- (2017) Seyyed Mehdi Jafari et al. CELLULAR ONCOLOGY
- The adenosine A2b receptor promotes tumor progression of bladder urothelial carcinoma by enhancing MAPK signaling pathway
- (2017) Yihong Zhou et al. Oncotarget
- Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer
- (2017) Yusuke Inoue et al. Oncotarget
- Inhibition of A2A Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455
- (2017) Stefania Gessi et al. Frontiers in Pharmacology
- What Else Can CD39 Tell Us?
- (2017) Hai Zhao et al. Frontiers in Immunology
- Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don’t Forget the Fuel
- (2017) Melita Irving et al. Frontiers in Immunology
- A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment
- (2017) Melanie Mediavilla-Varela et al. NEOPLASIA
- CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer
- (2017) Jieyao Li et al. OncoImmunology
- Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer
- (2017) Saly Al-Taei et al. OncoImmunology
- Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation
- (2017) Xiaohu Wang et al. EBioMedicine
- Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer
- (2016) S R Rao et al. BRITISH JOURNAL OF CANCER
- Adenosine A2A receptor promotes collagen type III synthesis via β-catenin activation in human dermal fibroblasts
- (2016) Gibran Shaikh et al. BRITISH JOURNAL OF PHARMACOLOGY
- Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses
- (2016) Arabella Young et al. CANCER CELL
- Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis
- (2016) F. Wirsdo rfer et al. CANCER RESEARCH
- Abstract 1476: A therapeutic antibody that inhibits CD73 activity by dual mechanisms
- (2016) Bryan C. Barnhart et al. CANCER RESEARCH
- Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis
- (2016) D. Mittal et al. CANCER RESEARCH
- Immunosuppressive activities of adenosine in cancer
- (2016) Bertrand Allard et al. CURRENT OPINION IN PHARMACOLOGY
- Monoclonal antibodies targeting CD38 in hematological malignancies and beyond
- (2016) Niels W. C. J. van de Donk et al. IMMUNOLOGICAL REVIEWS
- Mesenchymal stromal cells derived from cervical cancer produce high amounts of adenosine to suppress cytotoxic T lymphocyte functions
- (2016) María de Lourdes Mora-García et al. Journal of Translational Medicine
- Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action
- (2016) James C. Geoghegan et al. mAbs
- Overexpression of CD39 in hepatocellular carcinoma is an independent indicator of poor outcome after radical resection
- (2016) Xiao-Yan Cai et al. MEDICINE
- The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review)
- (2016) KUO YAN et al. Molecular Medicine Reports
- Mechanisms and regulation of endothelial VEGF receptor signalling
- (2016) Michael Simons et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases
- (2016) Bruce N. Cronstein et al. Nature Reviews Rheumatology
- Adenosine arrests breast cancer cell motility by A3 receptor stimulation
- (2016) Carola Ledderose et al. Purinergic Signalling
- Adenosine A2A receptor regulates expression of vascular endothelial growth factor in feto-placental endothelium from normal and late-onset pre-eclamptic pregnancies
- (2016) Jesenia Acurio et al. Purinergic Signalling
- Adenosinergic Immunosuppression by Human Mesenchymal Stromal Cells Requires Co-Operation with T cells
- (2016) Erja Kerkelä et al. STEM CELLS
- Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies
- (2016) Mohamed R. Akl et al. Oncotarget
- Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression
- (2016) Claudia Sorrentino et al. Oncotarget
- Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals
- (2016) Fengqin Fang et al. Cell Reports
- Augmentation of CAR T-cell Trafficking and Antitumor Efficacy by Blocking Protein Kinase A Localization
- (2016) K. Newick et al. Cancer Immunology Research
- Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units
- (2016) Vanessa L. Wehbi et al. Frontiers in Immunology
- The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27
- (2016) Sènan M. d’Almeida et al. OncoImmunology
- Targeting CD73 in the tumor microenvironment with MEDI9447
- (2016) Carl M. Hay et al. OncoImmunology
- Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape
- (2016) Itsaso Montalbán del Barrio et al. Journal for ImmunoTherapy of Cancer
- Adenosine A2b receptor promotes progression of human oral cancer
- (2015) Hiroki Kasama et al. BMC CANCER
- CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression
- (2015) María Rosa Bono et al. FEBS LETTERS
- Acquisition of new tumor cell properties by MSC-derived exosomes
- (2015) YUANYUAN YANG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Multi-Inhibitory Effects of A2AAdenosine Receptor Signaling on Neutrophil Adhesion Under Flow
- (2015) Tadayuki Yago et al. JOURNAL OF IMMUNOLOGY
- Bordetella pertussisAdenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase
- (2015) Ondrej Cerny et al. JOURNAL OF IMMUNOLOGY
- A Systems Oncology Approach Identifies NT5E as a Key Metabolic Regulator in Tumor Cells and Modulator of Platinum Sensitivity
- (2015) Ekaterina Nevedomskaya et al. JOURNAL OF PROTEOME RESEARCH
- Sleep deprivation and hippocampal vulnerability: changes in neuronal plasticity, neurogenesis and cognitive function
- (2015) J.C. Kreutzmann et al. NEUROSCIENCE
- p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death
- (2015) J S Long et al. ONCOGENE
- Immunological mechanisms of the antitumor effects of supplemental oxygenation
- (2015) Stephen M. Hatfield et al. Science Translational Medicine
- The future of EPAC-targeted therapies: agonism versus antagonism
- (2015) Euan Parnell et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation
- (2015) Jeniffer B. Hernandez et al. Nature Communications
- Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model
- (2015) Claudia Sorrentino et al. Oncotarget
- The cAMP response element modulator (CREM) regulates TH2 mediated inflammation
- (2015) Eva Verjans et al. Oncotarget
- Prognostic Significance of Serum Alkaline Phosphatase Level in Osteosarcoma: A Meta-Analysis of Published Data
- (2015) Hai-Yong Ren et al. Biomed Research International
- Adenosine Receptor 2A Blockade Increases the Efficacy of Anti–PD-1 through Enhanced Antitumor T-cell Responses
- (2015) Paul A. Beavis et al. Cancer Immunology Research
- Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells
- (2015) Patrícia S. de Araújo-Souza et al. Journal of Immunology Research
- Human ectonucleotidase-expressing CD25highTh17 cells accumulate in breast cancer tumors and exert immunosuppressive functions
- (2015) Marion Thibaudin et al. OncoImmunology
- Myeloid cells in the tumor microenvironment: Role of adenosine
- (2015) Silvana Morello et al. OncoImmunology
- Adenosine regulates radiation therapy-induced anti-tumor immunity
- (2015) Erik Wennerberg et al. Journal for ImmunoTherapy of Cancer
- Diverse Mechanisms of Sp1-Dependent Transcriptional Regulation Potentially Involved in the Adaptive Response of Cancer Cells to Oxygen-Deficient Conditions
- (2015) Shiro Koizume et al. Cancers
- Host A2B Adenosine Receptors Promote Carcinoma Growth
- (2015) Sergey Ryzhov et al. NEOPLASIA
- A2B and A3 Adenosine Receptors Modulate Vascular Endothelial Growth Factor and Interleukin-8 Expression in Human Melanoma Cells Treated with Etoposide and Doxorubicin
- (2015) Stefania Merighi et al. NEOPLASIA
- Adenosine A3 Receptor Suppresses Prostate Cancer Metastasis by Inhibiting NADPH Oxidase Activity
- (2015) Sarvesh Jajoo et al. NEOPLASIA
- Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma
- (2015) Raffaella Iannone et al. NEOPLASIA
- Unraveling the contribution of ectoenzymes to myeloma life and survival in the bone marrow niche
- (2014) Valeria Quarona et al. Annals of the New York Academy of Sciences
- Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment
- (2014) C. Cekic et al. CANCER RESEARCH
- Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment
- (2014) C. Cekic et al. CANCER RESEARCH
- Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor
- (2014) D. Mittal et al. CANCER RESEARCH
- Human CD4+CD39+regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+exosomes or CD73+cells
- (2014) P. J. Schuler et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence
- (2014) J. Ye et al. EMBO Molecular Medicine
- Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review)
- (2014) David Hoskin et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Adenosine
- (2014) Jamie Layland et al. JACC-Cardiovascular Interventions
- CREB, ATF, and AP-1 Transcription Factors Regulate IFN- Secretion by Human T Cells in Response to Mycobacterial Antigen
- (2014) B. Samten et al. JOURNAL OF IMMUNOLOGY
- Role of TGF-β Signaling in Generation of CD39+CD73+Myeloid Cells in Tumors
- (2014) Sergey V. Ryzhov et al. JOURNAL OF IMMUNOLOGY
- Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection
- (2014) Stephen M. Hatfield et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- PKA Reduces the Rat and Human KCa3.1 Current, CaM Binding, and Ca2+ Signaling, Which Requires Ser332/334 in the CaM-Binding C Terminus
- (2014) R. Wong et al. JOURNAL OF NEUROSCIENCE
- High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors
- (2014) Elisabet Aliagas et al. MEDIATORS OF INFLAMMATION
- Two Histone/Protein Acetyltransferases, CBP and p300, Are Indispensable for Foxp3+ T-Regulatory Cell Development and Function
- (2014) Y. Liu et al. MOLECULAR AND CELLULAR BIOLOGY
- Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis
- (2014) J Z Zhou et al. ONCOGENE
- Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease
- (2014) Maria Serena Longhi et al. PLoS One
- ATP-Based Chemotherapy Response Assay in Primary or Recurrent Ovarian and Peritoneal Cancer
- (2014) Maria Lee et al. YONSEI MEDICAL JOURNAL
- Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
- (2014) J. Bastid et al. Cancer Immunology Research
- Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death
- (2014) Encouse B Golden et al. OncoImmunology
- Extracellular Generation of Adenosine by the Ectonucleotidases CD39 and CD73 Promotes Dermal Fibrosis
- (2013) Patricia Fernández et al. AMERICAN JOURNAL OF PATHOLOGY
- Differential effect of adenosine receptors on growth of human colon cancer HCT 116 and HT-29 cell lines
- (2013) Monika Sakowicz-Burkiewicz et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Hypoxia and P1 receptor activation regulate the high-affinity concentrative adenosine transporter CNT2 in differentiated neuronal PC12 cells
- (2013) Lorena Medina-Pulido et al. BIOCHEMICAL JOURNAL
- Regulatory T-cells and cAMP suppress effector T-cells independently of PKA–CREM/ICER: a potential role for Epac
- (2013) Amanda G. Vang et al. BIOCHEMICAL JOURNAL
- Emerging Roles of Human Prostatic Acid Phosphatase
- (2013) Hoon Young Kong et al. Biomolecules & Therapeutics
- Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth
- (2013) Melanie Mediavilla-Varela et al. CANCER BIOLOGY & THERAPY
- Tumor promotion through the mesenchymal stem cell compartment in human hepatocellular carcinoma
- (2013) Pratika Y. Hernanda et al. CARCINOGENESIS
- Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
- (2013) B. Allard et al. CLINICAL CANCER RESEARCH
- Transcriptional regulation by hypoxia inducible factors
- (2013) Veronica L. Dengler et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+T cells contributes to their regulatory function
- (2013) Lesley Ann Smyth et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The Adenosine-Dependent Angiogenic Switch of Macrophages to an M2-Like Phenotype is Independent of Interleukin-4 Receptor Alpha (IL-4Rα) Signaling
- (2013) Christopher James Ferrante et al. INFLAMMATION
- Anti-CD73 therapy impairs tumor angiogenesis
- (2013) Bertrand Allard et al. INTERNATIONAL JOURNAL OF CANCER
- Forskolin-inducible cAMP Pathway Negatively Regulates T-cell Proliferation by Uncoupling the Interleukin-2 Receptor Complex
- (2013) Georgialina Rodriguez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients
- (2013) Geok Choo Sim et al. JOURNAL OF CLINICAL INVESTIGATION
- Extracellular adenosine regulates naive T cell development and peripheral maintenance
- (2013) Caglar Cekic et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cholera Toxin Directly Enhances IL-17A Production from Human CD4+ T Cells
- (2013) H.-C. Tsai et al. JOURNAL OF IMMUNOLOGY
- Selective Inhibition of KCa3.1 Channels Mediates Adenosine Regulation of the Motility of Human T Cells
- (2013) A. A. Chimote et al. JOURNAL OF IMMUNOLOGY
- Anti-Human CD73 Monoclonal Antibody Inhibits Metastasis Formation in Human Breast Cancer by Inducing Clustering and Internalization of CD73 Expressed on the Surface of Cancer Cells
- (2013) M. G. Terp et al. JOURNAL OF IMMUNOLOGY
- Adenosine A2A Receptor as a Drug Discovery Target
- (2013) Manuel de Lera Ruiz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Interrogating cAMP-dependent Kinase Signaling in Jurkat T Cells via a Protein Kinase A Targeted Immune-precipitation Phosphoproteomics Approach
- (2013) Piero Giansanti et al. MOLECULAR & CELLULAR PROTEOMICS
- IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39
- (2013) Ivan D Mascanfroni et al. NATURE IMMUNOLOGY
- Circulating and Tumor-Infiltrating Myeloid-Derived Suppressor Cells in Patients with Colorectal Carcinoma
- (2013) Bin Zhang et al. PLoS One
- Ensemble of Gene Signatures Identifies Novel Biomarkers in Colorectal Cancer Activated through PPARγ and TNFα Signaling
- (2013) Stefano Maria Pagnotta et al. PLoS One
- CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer
- (2013) S. Loi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors
- (2013) Paul A. Beavis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis
- (2013) C. J. Desmet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A2B adenosine receptor blockade inhibits growth of prostate cancer cells
- (2013) Qiang Wei et al. Purinergic Signalling
- Detecting adenosine triphosphate in the pericellular space
- (2013) S. Falzoni et al. Interface Focus
- The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study
- (2013) Geoff Bellingan et al. Lancet Respiratory Medicine
- Advanced stage of breast cancer hoist alkaline phosphatase activity: risk factor for females in India
- (2013) A. K. Singh et al. 3 Biotech
- The adenosinergic system in cancer
- (2013) Rosalinda Sorrentino et al. OncoImmunology
- A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes
- (2013) Alberto L Horenstein et al. OncoImmunology
- Modulation of KV1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex
- (2012) Zerrin Kuras et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Regulation of Macrophage Function by Adenosine
- (2012) György Haskó et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Regulation of Neutrophil Function by Adenosine
- (2012) Kathryn E. Barletta et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- CD73-Deficient Mice Are Resistant to Carcinogenesis
- (2012) J. Stagg et al. CANCER RESEARCH
- Adenosine Induces Apoptosis in SBC-3 Human Lung Cancer Cells through A3Adenosine Receptor-Dependent AMID Upregulation
- (2012) Takeshi Kanno et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- A3Adenosine Receptor-Mediated p53-Dependent Apoptosis in Lu-65 Human Lung Cancer Cells
- (2012) Tai-ichiro Otsuki et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- A review on CXCR4/CXCL12 axis in oncology: No place to hide
- (2012) Urszula M. Domanska et al. EUROPEAN JOURNAL OF CANCER
- Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression
- (2012) Fanny Chalmin et al. IMMUNITY
- Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+T-cell priming capacity
- (2012) John Challier et al. IMMUNOLOGY
- CD73-Generated Adenosine: Orchestrating the Tumor-Stroma Interplay to Promote Cancer Growth
- (2012) Bertrand Allard et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury
- (2012) Li Li et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of CD73 Improves B Cell-Mediated Anti-Tumor Immunity in a Mouse Model of Melanoma
- (2012) G. Forte et al. JOURNAL OF IMMUNOLOGY
- CD73 represses pro-inflammatory responses in human endothelial cells
- (2012) Jana KG Gr�newald et al. Journal of Inflammation-London
- Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease
- (2012) Jens M. Poth et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Extracellular NAD+: a danger signal hindering regulatory T cells
- (2012) Sahil Adriouch et al. MICROBES AND INFECTION
- CD38 deficiency in the tumor microenvironment attenuates glioma progression and modulates features of tumor-associated microglia/macrophages
- (2012) Ayelet Levy et al. NEURO-ONCOLOGY
- Multiple Analyses of G-Protein Coupled Receptor (GPCR) Expression in the Development of Gefitinib-Resistance in Transforming Non-Small-Cell Lung Cancer
- (2012) Naoko Kuzumaki et al. PLoS One
- Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
- (2012) K. Sarkar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cellular function and molecular structure of ecto-nucleotidases
- (2012) Herbert Zimmermann et al. Purinergic Signalling
- The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway
- (2012) Akio Ohta et al. Frontiers in Immunology
- Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor
- (2011) Adam T. Waickman et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity
- (2011) Sebastian F. M. Häusler et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- CNT1 Expression Influences Proliferation and Chemosensitivity in Drug-Resistant Pancreatic Cancer Cells
- (2011) Y. D. Bhutia et al. CANCER RESEARCH
- CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis
- (2011) J. Stagg et al. CANCER RESEARCH
- Generation of anti-inflammatory adenosine byleukocytes is regulated by TGF-β
- (2011) Frederico S. Regateiro et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
- (2011) Gennady G. Yegutkin et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Distinctive immunoregulatory effects of adenosine on T cells of older humans
- (2011) Charles S. Hesdorffer et al. FASEB JOURNAL
- Adenosine promotes alternative macrophage activation via A2A and A2B receptors
- (2011) Balázs Csóka et al. FASEB JOURNAL
- cAMP-responsive Element Modulator α (CREMα) Suppresses IL-17F Protein Expression in T Lymphocytes from Patients with Systemic Lupus Erythematosus (SLE)
- (2011) Christian M. Hedrich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Christian M. Hedrich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Thomas Rauen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Mahmoud Aghaei et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
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- (2011) Long Wang et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2011) A. Clayton et al. JOURNAL OF IMMUNOLOGY
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- (2011) J. M. Wilson et al. JOURNAL OF IMMUNOLOGY
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- (2011) S. Ryzhov et al. JOURNAL OF IMMUNOLOGY
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- (2011) C. Cekic et al. JOURNAL OF IMMUNOLOGY
- CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
- (2011) Judith Y. Altarejos et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update
- (2011) B. B. Fredholm et al. PHARMACOLOGICAL REVIEWS
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- (2011) M. Michaud et al. SCIENCE
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- (2011) Mark J. Zylka TRENDS IN MOLECULAR MEDICINE
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- (2011) Maria Nikolova et al. PLoS Pathogens
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- (2010) Katia Varani et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors
- (2010) Stefania Gessi et al. BIOCHEMICAL PHARMACOLOGY
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- (2010) N. G. Oberprieler et al. BLOOD
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- (2010) D. Jin et al. CANCER RESEARCH
- Chemotherapy induces ATP release from tumor cells
- (2010) Isabelle Martins et al. CELL CYCLE
- Wnt/ -Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy
- (2010) L. Gattinoni et al. CLINICAL CANCER RESEARCH
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- (2010) Eun-Young Jung et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death
- (2010) Leonóra Himer et al. FASEB JOURNAL
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- (2010) Xiaofeng Sun et al. GASTROENTEROLOGY
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- (2010) Jun Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) Akihiro Tokunaga et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) Hui Liao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) B. Duan et al. JOURNAL OF IMMUNOLOGY
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- (2010) A. Y. Wen et al. JOURNAL OF IMMUNOLOGY
- Modulation of Cytokine Production by Cyclic Adenosine Monophosphate Analogs in Human Leukocytes
- (2010) Sarah Gerlo et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins
- (2010) Guillaume Pidoux et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Vasoactive Intestinal Peptide Induces Cell Cycle Arrest and Regulatory Functions in Human T Cells at Multiple Levels
- (2010) P. Anderson et al. MOLECULAR AND CELLULAR BIOLOGY
- Extracellular adenosine triphosphate and adenosine in cancer
- (2010) J Stagg et al. ONCOGENE
- PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER
- (2010) Amanda G. Vang et al. PLoS One
- Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
- (2010) J. Stagg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A1 adenosine receptors
- (2009) Masaru Saito et al. CANCER LETTERS
- Adenosine mediated desensitization of cAMP signaling enhances T-cell responses
- (2009) Ailian Yang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The functional network of ion channels in T lymphocytes
- (2009) Michael D. Cahalan et al. IMMUNOLOGICAL REVIEWS
- Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling
- (2009) Carsten Linnemann et al. IMMUNOLOGY
- HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia
- (2009) Meixiang Yang et al. IMMUNOLOGY AND CELL BIOLOGY
- Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A2a adenosine receptors
- (2009) Yoshiyuki Yasuda et al. JOURNAL OF GASTROENTEROLOGY
- Human Follicular Lymphoma CD39+-Infiltrating T Cells Contribute to Adenosine-Mediated T Cell Hyporesponsiveness
- (2009) S. P. Hilchey et al. JOURNAL OF IMMUNOLOGY
- Inhibition of cAMP Degradation Improves Regulatory T Cell-Mediated Suppression
- (2009) T. Bopp et al. JOURNAL OF IMMUNOLOGY
- The A2B Adenosine Receptor Impairs the Maturation and Immunogenicity of Dendritic Cells
- (2009) J. M. Wilson et al. JOURNAL OF IMMUNOLOGY
- A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments
- (2009) A. Ohta et al. JOURNAL OF IMMUNOLOGY
- Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells
- (2009) Alexandr V. Bazhin et al. MOLECULAR IMMUNOLOGY
- Adenylyl Cyclase-A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling
- (2009) C. W. Dessauer MOLECULAR PHARMACOLOGY
- A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence
- (2009) M S Alam et al. Mucosal Immunology
- BioNumbers—the database of key numbers in molecular and cell biology
- (2009) Ron Milo et al. NUCLEIC ACIDS RESEARCH
- Adenosine A1 receptor, a target and regulator of estrogen receptorα action, mediates the proliferative effects of estradiol in breast cancer
- (2009) Z Lin et al. ONCOGENE
- Heightened NTPDase-1/CD39 expression and angiogenesis in radiation proctitis
- (2009) Sunil Sheth et al. Purinergic Signalling
- Prostatic acid phosphatase, a neglected ectonucleotidase
- (2009) Herbert Zimmermann Purinergic Signalling
- Differential ectonucleotidase expression in human bladder cancer cell lines
- (2009) Joséli Stella et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Epac and PKA: a tale of two intracellular cAMP receptors
- (2008) Xiaodong Cheng et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
- (2008) Gennady G. Yegutkin BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Adenosine receptors in regulation of dendritic cell differentiation and function
- (2008) S. V. Novitskiy et al. BLOOD
- Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
- (2008) H. K. Eltzschig et al. BLOOD
- Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP–PKA signaling and immunosuppression
- (2008) Yunyun Su et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Modulation of murine dendritic cell function by adenine nucleotides and adenosine: Involvement of the A2B receptor
- (2008) Abduelhakem Ben Addi et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function
- (2008) Balázs Csóka et al. FASEB JOURNAL
- Hypoxia-Inducible Factor–Dependent Repression of Equilibrative Nucleoside Transporter 2 Attenuates Mucosal Inflammation During Intestinal Hypoxia
- (2008) Julio C. Morote–Garcia et al. GASTROENTEROLOGY
- Suppression of T-Lymphocyte Activation and Chemotaxis by the Adenylate Cyclase Toxin of Bordetella pertussis
- (2008) S. R. Paccani et al. INFECTION AND IMMUNITY
- Mechanisms of induction of adenosine receptor genes and its functional significance
- (2008) Cynthia St. Hilaire et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels
- (2008) U. Schenk et al. Science Signaling
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