Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units

PKA-Type I Selective Constrained Peptide Disruptors of AKAP Complexes

(2015) Yuxiao Wang et al.   ACS Chemical Biology

Cyclooxygenase inhibitors: From pharmacology to clinical read-outs

(2015) Paola Patrignani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity

(2015) Bing Liu et al.   Cancer Cell International

Pharmacological targeting of AKAP-directed compartmentalized cAMP signalling

(2015) Alessandro Dema et al.   CELLULAR SIGNALLING

Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3′,5′-cyclic adenosine monophosphate-signaling pathway

(2015) Z. Raslan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The cAMP response element modulator (CREM) regulates TH2 mediated inflammation

(2015) Eva Verjans et al.   Oncotarget

CD4+ T Cell Differentiation in Infection: Amendments to the Th1/Th2 Axiom

(2015) Dragana Jankovic et al.   Frontiers in Immunology

Correction to Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides

(2014) Yuxiao Wang et al.   ACS Chemical Biology

Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases

(2014) Carolina Otero et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

(2014) Nicholas van Panhuys et al.   IMMUNITY

A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion

(2014) G. Pidoux et al.   JOURNAL OF CELL SCIENCE

Ezrin and Moesin Function Together to Promote T Cell Activation

(2014) M. H. Shaffer et al.   JOURNAL OF IMMUNOLOGY

The Late Endosomal Transporter CD222 Directs the Spatial Distribution and Activity of Lck

(2014) Karin Pfisterer et al.   JOURNAL OF IMMUNOLOGY

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

(2014) Loren D. Walensky et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

Regulatory T-cells and cAMP suppress effector T-cells independently of PKA–CREM/ICER: a potential role for Epac

(2013) Amanda G. Vang et al.   BIOCHEMICAL JOURNAL

Super-resolution microscopy of the immunological synapse

(2013) Jérémie Rossy et al.   CURRENT OPINION IN IMMUNOLOGY

The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice

(2013) Maneesh Singh et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Engineering A-kinase Anchoring Protein (AKAP)-selective Regulatory Subunits of Protein Kinase A (PKA) through Structure-based Phage Selection

(2013) Matthew G. Gold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Forskolin-inducible cAMP Pathway Negatively Regulates T-cell Proliferation by Uncoupling the Interleukin-2 Receptor Complex

(2013) Georgialina Rodriguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erratum: Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase

(2013) Chengcan Yao et al.   Nature Communications

Proinflammatory and Immunoregulatory Roles of Eicosanoids in T Cells

(2013) Anna Mari Lone et al.   Frontiers in Immunology

Apremilast mechanism of action and application to psoriasis and psoriatic arthritis

(2012) Peter Schafer   BIOCHEMICAL PHARMACOLOGY

Cyclic AMP underpins suppression by regulatory T cells

(2012) Josef Bodor et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phosphodiesterase inhibitors in inflammatory bowel disease

(2012) Pooneh Salari et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses

(2012) Jinfang Zhu et al.   IMMUNITY

LYP inhibits T-cell activation when dissociated from CSK

(2012) Torkel Vang et al.   Nature Chemical Biology

Modulation of T cell immune functions by the prostaglandin E2 - cAMP pathway in chronic inflammatory states

(2011) Kristoffer Watten Brudvik et al.   BRITISH JOURNAL OF PHARMACOLOGY

AKAPs in lipid rafts are required for optimal antigen presentation by dendritic cells

(2011) Robynn V Schillace et al.   IMMUNOLOGY AND CELL BIOLOGY

Prostaglandin E2 and T cells: friends or foes?

(2011) Vinatha Sreeramkumar et al.   IMMUNOLOGY AND CELL BIOLOGY

Palmitoylation Targets AKAP79 Protein to Lipid Rafts and Promotes Its Regulation of Calcium-sensitive Adenylyl Cyclase Type 8

(2011) Ilse Delint-Ramirez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice with Disrupted Type I Protein Kinase A Anchoring in T Cells Resist Retrovirus-Induced Immunodeficiency

(2011) R. Mosenden et al.   JOURNAL OF IMMUNOLOGY

Th2 Responses to Helminth Parasites Can Be Therapeutically Enhanced by, but Are Not Dependent upon, GITR-GITR Ligand Costimulation In Vivo

(2011) N. van der Werf et al.   JOURNAL OF IMMUNOLOGY

Connexin 43 Signaling Enhances the Generation of Foxp3+ Regulatory T Cells

(2011) M. Kuczma et al.   JOURNAL OF IMMUNOLOGY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

An Exploratory Trial of Cyclooxygenase Type 2 Inhibitor in HIV-1 Infection: Downregulated Immune Activation and Improved T Cell-Dependent Vaccine Responses

(2011) F. O. Pettersen et al.   JOURNAL OF VIROLOGY

Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice

(2011) Kristoffer W Brudvik et al.   Molecular Cancer

Do aspirin and other NSAIDs protect against colorectal cancer?

(2011) Sarah Kraus et al.   Nature Reviews Gastroenterology & Hepatology

Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions

(2011) Sharron H. Francis et al.   PHYSIOLOGICAL REVIEWS

PGE2 inhibits natural killer and γδ T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling

(2010) Ludovic Martinet et al.   BIOCHEMICAL PHARMACOLOGY

Prostaglandin E2 regulates cellular migration via induction of vascular endothelial growth factor receptor-1 in HCA-7 human colon cancer cells

(2010) Hiromichi Fujino et al.   BIOCHEMICAL PHARMACOLOGY

High-resolution mapping of prostaglandin E2-dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells

(2010) N. G. Oberprieler et al.   BLOOD

Integrin and CD3/TCR activation are regulated by the scaffold protein AKAP450

(2010) J. Robles-Valero et al.   BLOOD

Stimulation of β2-adrenergic receptors inhibits calcineurin activity in CD4+ T cells via PKA–AKAP interaction

(2010) Carsten Riether et al.   BRAIN BEHAVIOR AND IMMUNITY

Induction of MTG8-specific cytotoxic T-cell lines: MTG8 is probably a tumour antigen that is recognized by cytotoxic T cells in AML1-MTG8-fused gene-positive acute myelogenous leukaemia

(2010) Motoi Maeda et al.   BRITISH JOURNAL OF HAEMATOLOGY

Intratumoral forkhead box P3-positive regulatory T cells predict poor survival in cyclooxygenase-2-positive uveal melanoma

(2010) Dimitrios Mougiakakos et al.   CANCER

Cyclic AMP-mediated immune regulation — Overview of mechanisms of action in T cells

(2010) Randi Mosenden et al.   CELLULAR SIGNALLING

Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells

(2010) Isabelle Cornez et al.   FEBS LETTERS

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

Novel mechanism of signaling by CD28

(2010) Elisa Bjørgo et al.   IMMUNOLOGY LETTERS

Small-molecule protein-protein interaction inhibitors: Therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations

(2010) Peter Buchwald   IUBMB LIFE

The Role of the Transcription Factor CREB in Immune Function

(2010) A. Y. Wen et al.   JOURNAL OF IMMUNOLOGY

Control of the proliferation of activated CD4+ T cells by connexins

(2010) Ernesto Oviedo-Orta et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins

(2010) Guillaume Pidoux et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells

(2010) Julia K. Polansky et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/ -Arrestin/cAMP Phosphodiesterase 4 Complex

(2010) E. Bjorgo et al.   MOLECULAR AND CELLULAR BIOLOGY

Networking with AKAPs: Context-dependent Regulation of Anchored Enzymes

(2010) E. J. Welch et al.   MOLECULAR INTERVENTIONS

A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

(2010) Byron B Au-Yeung et al.   NATURE IMMUNOLOGY

Design of proteolytically stable RI-anchoring disruptor peptidomimetics forin vivostudies of anchored type I protein kinase A-mediated signalling

(2009) Eirik A. Torheim et al.   BIOCHEMICAL JOURNAL

The adaptor protein EBP50 is important for localization of the protein kinase A–Ezrin complex in T-cells and the immunomodulating effect of cAMP

(2009) Anne Jorunn Stokka et al.   BIOCHEMICAL JOURNAL

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of cAMP Degradation Improves Regulatory T Cell-Mediated Suppression

(2009) T. Bopp et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of Opioid-Mediated Inhibition of Human T Cell Receptor Signaling

(2009) C. Borner et al.   JOURNAL OF IMMUNOLOGY

Suppression of LPS-Induced TNF-  Production in Macrophages by cAMP Is Mediated by PKA-AKAP95-p105

(2009) E. A. Wall et al.   Science Signaling

Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring

(2008) Omar M. Faruque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP–PKA signaling and immunosuppression

(2008) Yunyun Su et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Contemporary strategies for the stabilization of peptides in the α-helical conformation

(2008) Laura K Henchey et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

miR-142-3p restricts cAMP production in CD4+CD25− T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA

(2008) Bo Huang et al.   EMBO REPORTS

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dual Specificity A-kinase Anchoring Proteins (AKAPs) Contain an Additional Binding Region That Enhances Targeting of Protein Kinase A Type I

(2008) Elisabeth Jarnæss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AKAP149 Binds to HIV-1 Reverse Transcriptase and Is Involved in the Reverse Transcription

(2008) Julie Lemay et al.   JOURNAL OF MOLECULAR BIOLOGY

Ezrin/radixin/moesin: Versatile controllers of signaling molecules and of the cortical cytoskeleton

(2007) Verena Niggli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY