Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer

CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice

(2017) Farhad Jadidi-Niaragh et al.   JOURNAL OF CONTROLLED RELEASE

Adenosine Activates AMPK to Phosphorylate Bcl-XL Responsible for Mitochondrial Damage and DIABLO Release in HuH-7 Cells

(2017) Donqin Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The role of adenosine and adenosine receptors in the immunopathogenesis of multiple sclerosis

(2016) Elham Safarzadeh et al.   INFLAMMATION RESEARCH

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

(2016) Danny N. Khalil et al.   Nature Reviews Clinical Oncology

Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration

(2016) Patrycja Koszałka et al.   PLoS One

Downregulation of CD73 in 4T1 breast cancer cells through siRNA-loaded chitosan-lactate nanoparticles

(2016) Farhad Jadidi-Niaragh et al.   TUMOR BIOLOGY

Targeting tumor-associated macrophages to combat pancreatic cancer

(2016) Ran Cui et al.   Oncotarget

MicroRNA-128b suppresses tumor growth and promotes apoptosis by targeting A2bR in gastric cancer

(2015) Ping Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptor

(2015) Hadar Eini et al.   BIOCHEMICAL PHARMACOLOGY

Adenosine A2b receptor promotes progression of human oral cancer

(2015) Hiroki Kasama et al.   BMC CANCER

Involvement of purinergic system in the release of cytokines by macrophages exposed to glioma-conditioned medium

(2015) Letícia Scussel Bergamin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Loss of CD73-mediated actin polymerization promotes endometrial tumor progression

(2015) Jessica L. Bowser et al.   JOURNAL OF CLINICAL INVESTIGATION

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death

(2015) J S Long et al.   ONCOGENE

Myeloid-derived suppressor cells in B cell malignancies

(2015) Yaghoub Yazdani et al.   TUMOR BIOLOGY

Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model

(2015) Claudia Sorrentino et al.   Oncotarget

Adenosine Receptor 2A Blockade Increases the Efficacy of Anti–PD-1 through Enhanced Antitumor T-cell Responses

(2015) Paul A. Beavis et al.   Cancer Immunology Research

Ecto-5’-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model

(2015) Angélica R. Cappellari et al.   PLoS One

Host A2B Adenosine Receptors Promote Carcinoma Growth

(2015) Sergey Ryzhov et al.   NEOPLASIA

A2B and A3 Adenosine Receptors Modulate Vascular Endothelial Growth Factor and Interleukin-8 Expression in Human Melanoma Cells Treated with Etoposide and Doxorubicin

(2015) Stefania Merighi et al.   NEOPLASIA

Adenosine A3 Receptor Suppresses Prostate Cancer Metastasis by Inhibiting NADPH Oxidase Activity

(2015) Sarvesh Jajoo et al.   NEOPLASIA

NK1.1+ Cells and CD8+ T Cells Mediate the Antitumor Activity of Cl-IB-MECA in a Mouse Melanoma Model

(2015) Silvana Morello et al.   NEOPLASIA

Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma

(2015) Raffaella Iannone et al.   NEOPLASIA

The combination of Cl-IB-MECA with paclitaxel: a new anti-metastatic therapeutic strategy for melanoma

(2014) Ana S. Soares et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor

(2014) D. Mittal et al.   CANCER RESEARCH

The HIF-2alpha dependent induction of PAP and adenosine synthesis regulates glioblastoma stem cell function through the A2B adenosine receptor

(2014) Tian-zhu Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis

(2014) J Z Zhou et al.   ONCOGENE

Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy

(2014) S Daniele et al.   Cell Death & Disease

Differential effect of adenosine receptors on growth of human colon cancer HCT 116 and HT-29 cell lines

(2013) Monika Sakowicz-Burkiewicz et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth

(2013) Melanie Mediavilla-Varela et al.   CANCER BIOLOGY & THERAPY

Apoptosis-Related Gene Transcription in Human A549 Lung Cancer Cells via A3Adenosine Receptor

(2013) Hitomi Kamiya et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

CF102 for the Treatment of Hepatocellular Carcinoma: A Phase I/II, Open-Label, Dose-Escalation Study

(2013) S. M. Stemmer et al.   ONCOLOGIST

Pulsed Electromagnetic Fields Increased the Anti-Inflammatory Effect of A2A and A3 Adenosine Receptors in Human T/C-28a2 Chondrocytes and hFOB 1.19 Osteoblasts

(2013) Fabrizio Vincenzi et al.   PLoS One

MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells

(2013) Jesse Lyons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

(2013) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors

(2013) Paul A. Beavis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis

(2013) C. J. Desmet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A2B adenosine receptor blockade inhibits growth of prostate cancer cells

(2013) Qiang Wei et al.   Purinergic Signalling

Regulatory T cells in chronic lymphocytic leukemia: implication for immunotherapeutic interventions

(2013) Farhad Jadidi-Niaragh et al.   TUMOR BIOLOGY

The role of natural killer T cells in B cell malignancies

(2013) Ghasem Ghalamfarsa et al.   TUMOR BIOLOGY

Adenosine Induces Apoptosis in SBC-3 Human Lung Cancer Cells through A3Adenosine Receptor-Dependent AMID Upregulation

(2012) Takeshi Kanno et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A3Adenosine Receptor-Mediated p53-Dependent Apoptosis in Lu-65 Human Lung Cancer Cells

(2012) Tai-ichiro Otsuki et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

AMP Converted from Intracellularly Transported Adenosine Upregulates p53 Expression to Induce Malignant Pleural Mesothelioma Cell Apoptosis

(2012) Yoshitaka Nogi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cordycepin as a sensitizer to tumour necrosis factor (TNF)-α-induced apoptosis through eukaryotic translation initiation factor 2α (eIF2α)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-κB

(2012) M. Kadomatsu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The stimulation of A3 adenosine receptors reduces bone-residing breast cancer in a rat preclinical model

(2012) Katia Varani et al.   EUROPEAN JOURNAL OF CANCER

A3 Adenosine Receptor Mediates Apoptosis in In Vitro RCC4-VHL Human Renal Cancer Cells by Up-Regulating AMID Expression

(2012) Hisao Nagaya et al.   JOURNAL OF UROLOGY

The Anti-Tumor Effect of A3 Adenosine Receptors Is Potentiated by Pulsed Electromagnetic Fields in Cultured Neural Cancer Cells

(2012) Fabrizio Vincenzi et al.   PLoS One

Adoptive Immunotherapy with Cl-IB-MECA-Treated CD8+ T Cells Reduces Melanoma Growth in Mice

(2012) Antonella Montinaro et al.   PLoS One

Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor

(2011) Adam T. Waickman et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phosphorylatable short peptide conjugated low molecular weight chitosan for efficient siRNA delivery and target gene silencing

(2011) Fanqiang Kong et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Molecular mechanisms of A3 adenosine receptor-induced G1 cell cycle arrest and apoptosis in androgen-dependent and independent prostate cancer cell lines: involvement of intrinsic pathway

(2011) Mahmoud Aghaei et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors

(2011) C. Cekic et al.   JOURNAL OF IMMUNOLOGY

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Adenosine induces cell-cycle arrest and apoptosis in androgen-dependent and -independent prostate cancer cell lines, LNcap-FGC-10, DU-145, and PC3

(2011) Mahmoud Aghaei et al.   PROSTATE

Adenosine A2A and A2B receptor expression in neuroendocrine tumours: potential targets for therapy

(2011) A. Kalhan et al.   Purinergic Signalling

Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors

(2010) Stefania Gessi et al.   BIOCHEMICAL PHARMACOLOGY

Cl-IB-MECA inhibits human thyroid cancer cell proliferation independently of A3 adenosine receptor activation

(2010) Silvana Morello et al.   CANCER BIOLOGY & THERAPY

Adenosine-induced caspase-3 activation by tuning Bcl-XL/DIABLO/IAP expression in HuH-7 human hepatoma cells

(2010) Dongqin Yang et al.   CELL BIOLOGY AND TOXICOLOGY

Update on castrate-resistant prostate cancer: 2010

(2010) Kiran Lassi et al.   CURRENT OPINION IN ONCOLOGY

A2B Receptor Ligands: Past, Present and Future Trends

(2010) G. Ortore et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells

(2010) De-Fu Ma et al.   HUMAN PATHOLOGY

CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver

(2010) S. Cohen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Structure-Based Discovery of Novel Chemotypes for Adenosine A2AReceptor Antagonists

(2010) Vsevolod Katritch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Discovery of A2AAdenosine Receptor Ligands

(2010) Jens Carlsson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

(2009) Yi-Wei Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Adenosine receptors interacting proteins (ARIPs): Behind the biology of adenosine signaling

(2009) Francisco Ciruela et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

In vitroinduction of T cells that are resistant to A2adenosine receptor-mediated immunosuppression

(2009) Akio Ohta et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A1 adenosine receptors

(2009) Masaru Saito et al.   CANCER LETTERS

The anti-inflammatory target A3 adenosine receptor is over-expressed in rheumatoid arthritis, psoriasis and Crohn’s disease

(2009) A. Ochaion et al.   CELLULAR IMMUNOLOGY

Inflammation, Microenvironment, and the Immune System in Cancer Progression

(2009) Andrew Keibel et al.   CURRENT PHARMACEUTICAL DESIGN

HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia

(2009) Meixiang Yang et al.   IMMUNOLOGY AND CELL BIOLOGY

Cl-IB-MECA enhances TRAIL-induced apoptosis via the modulation of NF-κB signalling pathway in thyroid cancer cells

(2009) Silvana Morello et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A2a adenosine receptors

(2009) Yoshiyuki Yasuda et al.   JOURNAL OF GASTROENTEROLOGY

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

Adenosine A1 receptor, a target and regulator of estrogen receptorα action, mediates the proliferative effects of estradiol in breast cancer

(2009) Z Lin et al.   ONCOGENE

A2B adenosine receptors in immunity and inflammation

(2009) György Haskó et al.   TRENDS IN IMMUNOLOGY

The Adenosine A2a Receptor Inhibits Matrix-Induced Inflammation in a Novel Fashion

(2008) Kara A. Scheibner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Adenosine receptors in regulation of dendritic cell differentiation and function

(2008) S. V. Novitskiy et al.   BLOOD

Inhibition of cell proliferation through cell cycle arrest and apoptosis by thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, in human lung cancer cells

(2008) Sun-Jack Kim et al.   CANCER LETTERS

Adenosine Receptor Antagonists:  Translating Medicinal Chemistry and Pharmacology into Clinical Utility

(2008) Pier Giovanni Baraldi et al.   CHEMICAL REVIEWS

Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage

(2008) Olga Björklund et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A2A Receptor Antagonist MSX-2

(2008) Karl Vollmann et al.   MOLECULES

The A2b adenosine receptor protects against vascular injury

(2008) D. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

Suppression of inflammatory and immune responses by the A2A adenosine receptor: an introduction

(2007) T M Palmer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine Prevents the Death of Mesencephalic Dopaminergic Neurons by a Mechanism that Involves Astrocytes

(2003) Patrick P. Michel et al.   JOURNAL OF NEUROCHEMISTRY