Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape

CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation

(2016) Vinit Kumar et al.   IMMUNITY

Purinergic Signaling During Immune Cell Trafficking

(2016) Davide Ferrari et al.   TRENDS IN IMMUNOLOGY

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Regulatory T Cells from Colon Cancer Patients Inhibit Effector T-cell Migration through an Adenosine-Dependent Mechanism

(2016) P. Sundstro m et al.   Cancer Immunology Research

Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells

(2015) Thomas Condamine et al.   Annual Review of Medicine

Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

Adenosine in fibrosis

(2014) Edwin S. L. Chan et al.   Modern Rheumatology

Novel effects of adenosine receptors on pericellular hyaluronan matrix: implications for human smooth muscle cell phenotype and interactions with monocytes during atherosclerosis

(2013) M. Grandoch et al.   BASIC RESEARCH IN CARDIOLOGY

Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: Correlation of CD163 expression, cytokine levels and early relapse

(2013) Silke Reinartz et al.   INTERNATIONAL JOURNAL OF CANCER

Macrophage Scavenger Receptor A Promotes Tumor Progression in Murine Models of Ovarian and Pancreatic Cancer

(2013) C. Neyen et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal Stem Cells Tune the Development of Monocyte-Derived Dendritic Cells Toward a Myeloid-Derived Suppressive Phenotype through Growth-Regulated Oncogene Chemokines

(2013) H.-W. Chen et al.   JOURNAL OF IMMUNOLOGY

Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states

(2013) Maria Serena Longhi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Adenosine signaling during acute and chronic disease states

(2013) Harry Karmouty-Quintana et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

(2013) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD73-Deficient Mice Are Resistant to Carcinogenesis

(2012) J. Stagg et al.   CANCER RESEARCH

Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients

(2012) Balázs Győrffy et al.   ENDOCRINE-RELATED CANCER

Anti-tumour strategies aiming to target tumour-associated macrophages

(2012) Xiaoqiang Tang et al.   IMMUNOLOGY

Overexpression of CD73 in epithelial ovarian carcinoma is associated with better prognosis, lower stage, better differentiation and lower regulatory T cell infiltration

(2012) Hoon Kyu Oh et al.   Journal of Gynecologic Oncology

Inhibition of CD73 Improves B Cell-Mediated Anti-Tumor Immunity in a Mouse Model of Melanoma

(2012) G. Forte et al.   JOURNAL OF IMMUNOLOGY

High expression of CD73 as a poor prognostic biomarker in human colorectal cancer

(2012) Xian-Rui Wu et al.   JOURNAL OF SURGICAL ONCOLOGY

Differential Macrophage Activation Alters the Expression Profile of NTPDase and Ecto-5′-Nucleotidase

(2012) Rafael Fernandes Zanin et al.   PLoS One

CD73: a potent suppressor of antitumor immune responses

(2012) Paul. A. Beavis et al.   TRENDS IN IMMUNOLOGY

A3 Adenosine Receptor Agonist Reduces Brain Ischemic Injury and Inhibits Inflammatory Cell Migration in Rats

(2011) In-Young Choi et al.   AMERICAN JOURNAL OF PATHOLOGY

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

(2011) Sebastian F. M. Häusler et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates

(2011) W. H. Fridman et al.   CANCER RESEARCH

The comprehensive assessment of local immune status of ovarian cancer by the clustering of multiple immune factors

(2011) Junzo Hamanishi et al.   CLINICAL IMMUNOLOGY

Mononuclear phagocyte heterogeneity in cancer: Different subsets and activation states reaching out at the tumor site

(2011) Damya Laoui et al.   IMMUNOBIOLOGY

Peritoneal Immune System in Patients with Advance Epithelial Ovarian Cancer

(2011) Iwona Wertel et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells

(2011) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

CD73 Expression as a Potential Marker of Good Prognosis in Breast Carcinoma

(2011) Anna Supernat et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression

(2010) D. Jin et al.   CANCER RESEARCH

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

(2010) L. Aymeric et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Myeloid-derived suppressor cell heterogeneity and subset definition

(2010) Elisa Peranzoni et al.   CURRENT OPINION IN IMMUNOLOGY

Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death

(2010) Leonóra Himer et al.   FASEB JOURNAL

A cell-based luciferase-dependent assay for the quantitative determination of free extracellular adenosine with paracrine signaling activity

(2010) Sebastian F.M. Häusler et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors

(2009) Kyoko Kawamura et al.   PATHOLOGY INTERNATIONAL

Deletion of Cd39/Entpd1 Results in Hepatic Insulin Resistance

(2008) K. Enjyoji et al.   DIABETES

Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function

(2008) Balázs Csóka et al.   FASEB JOURNAL

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of enteric functions by adenosine: Pathophysiological and pharmacological implications

(2008) Luca Antonioli et al.   PHARMACOLOGY & THERAPEUTICS