Human CD4+CD39+regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+exosomes or CD73+cells

CD4+CD73+ T cells are associated with lower T-cell activation and C reactive protein levels and are depleted in HIV-1 infection regardless of viral suppression

(2013) Patrick J. Schuler et al.   AIDS

Adenosine production by human B cells and B cell-mediated suppression of activated T cells

(2013) Z. Saze et al.   BLOOD

CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+T cells contributes to their regulatory function

(2013) Lesley Ann Smyth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

(2012) T. Duhen et al.   BLOOD

Phenotypic and functional characteristics of CD4+CD39+ FOXP3+ and CD4+CD39+FOXP3neg T-cell subsets in cancer patients

(2012) Patrick J. Schuler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Induced and natural regulatory T cells in human cancer

(2012) Theresa L. Whiteside et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

AMP Is an Adenosine A1Receptor Agonist

(2012) Joseph E. Rittiner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD73-Generated Adenosine: Orchestrating the Tumor-Stroma Interplay to Promote Cancer Growth

(2012) Bertrand Allard et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Production of Adenosine by Ectonucleotidases: A Key Factor in Tumor Immunoescape

(2012) François Ghiringhelli et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

ENTPD1/CD39 is a promising therapeutic target in oncology

(2012) J Bastid et al.   ONCOGENE

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

(2012) Akio Ohta et al.   Frontiers in Immunology

CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4+T effector cells in patients with head and neck squamous cell carcinoma

(2012) Magis Mandapathil et al.   OncoImmunology

Tumor antigen specific iTreg accumulate in the tumor microenvironment and suppress therapeutic vaccination

(2012) Taylor H. Schreiber et al.   OncoImmunology

Exosomes and Cancer: A Newly Described Pathway of Immune Suppression

(2011) H.-G. Zhang et al.   CLINICAL CANCER RESEARCH

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

(2011) M. J. Szczepanski et al.   HAEMATOLOGICA

CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice

(2011) Long Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsets

(2011) Patrick J. Schuler et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Expression of CD39 by Human Peripheral Blood CD4+CD25+ T Cells Denotes a Regulatory Memory Phenotype

(2010) K. M. Dwyer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Adenosine and Prostaglandin E2Cooperate in the Suppression of Immune Responses Mediated by Adaptive Regulatory T Cells

(2010) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Expression of the Ectonucleotidase CD39 on T Cells from the Inflamed Site Identifies Two Distinct Populations, One Regulatory and One Memory T Cell Population

(2010) H. Moncrieffe et al.   JOURNAL OF IMMUNOLOGY

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+Regulatory T Cells

(2009) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression

(2009) Magis Mandapathil et al.   JOURNAL OF IMMUNOLOGICAL METHODS