Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle

Myostatin facilitates slow and inhibits fast myosin heavy chain expression during myogenic differentiation

(2012) Min Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation

(2012) W. Liu et al.   DEVELOPMENT

Myostatin Inhibition Prevents Diabetes and Hyperphagia in a Mouse Model of Lipodystrophy

(2012) T. Guo et al.   DIABETES

Myostatin: more than just a regulator of muscle mass

(2012) Josep M. Argilés et al.   DRUG DISCOVERY TODAY

A Novel Therapeutic Approach to Treating Obesity through Modulation of TGFβ Signaling

(2012) Alan Koncarevic et al.   ENDOCRINOLOGY

Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues

(2012) Tizhong Shan et al.   FASEB JOURNAL

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

(2012) B. Fournier et al.   MOLECULAR AND CELLULAR BIOLOGY

Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells

(2012) Y. Wen et al.   MOLECULAR AND CELLULAR BIOLOGY

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Irisin, Light My Fire

(2012) D. P. Kelly   SCIENCE

Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues

(2011) Tomas B. Waldén et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

(2011) Lei Cao et al.   Cell Metabolism

Intramuscular adipose is derived from a non-Pax3 lineage and required for efficient regeneration of skeletal muscles

(2011) Weiyi Liu et al.   DEVELOPMENTAL BIOLOGY

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

(2011) C. Zhang et al.   DIABETOLOGIA

Building muscle, browning fat and preventing obesity by inhibiting myostatin

(2011) N. K. LeBrasseur   DIABETOLOGIA

Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway

(2011) C. Zhang et al.   DIABETOLOGIA

Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization

(2011) Won Kon Kim et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function

(2010) Kate T. Murphy et al.   FASEB JOURNAL

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Postnatal PPARδ Activation and Myostatin Inhibition Exert Distinct yet Complimentary Effects on the Metabolic Profile of Obese Insulin-Resistant Mice

(2010) Barbara L. Bernardo et al.   PLoS One

UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity

(2010) Lise Madsen et al.   PLoS One

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

(2010) T. J. Schulz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myostatin regulates fiber-type composition of skeletal muscle by regulating MEF2 and MyoD gene expression

(2009) Alex Hennebry et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

AMPK activation is fiber type specific in human skeletal muscle: effects of exercise and short-term exercise training

(2009) Robert S. Lee-Young et al.   JOURNAL OF APPLIED PHYSIOLOGY

Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice

(2009) N. K. LeBrasseur et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

(2009) Tingqing Guo et al.   PLoS One

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE