EJE PRIZE 2017: Hypothalamic AMPK: a golden target against obesity?

Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression

(2016) Tae Seok Oh et al.   Autophagy

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

(2016) Brian Finan et al.   CELL

Unimolecular Polypharmacy for Treatment of Diabetes and Obesity

(2016) Matthias H. Tschöp et al.   Cell Metabolism

Molecular mechanisms of appetite and obesity: a role for brain AMPK

(2016) P. B. Martinez de Morentin et al.   CLINICAL SCIENCE

Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity

(2016) Cristina Contreras et al.   DIABETES

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

(2016) Fiona A. Ross et al.   FEBS Journal

Hypothalamus and thermogenesis: Heating the BAT, browning the WAT

(2016) Cristina Contreras et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

(2016) Miguel López et al.   Nature Reviews Endocrinology

Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance

(2016) Ismael González-García et al.   NEUROENDOCRINOLOGY

Extracellular vesicles: Pharmacological modulators of the peripheral and central signals governing obesity

(2016) Edward Milbank et al.   PHARMACOLOGY & THERAPEUTICS

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Glucagon-Like Peptide 1 Analogs and their Effects on Pancreatic Islets

(2016) Eva Tudurí et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance

(2016) Luís Martins et al.   Cell Reports

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance

(2016) Mayte Alvarez-Crespo et al.   Molecular Metabolism

GLP-1 analog liraglutide protects against cardiac steatosis, oxidative stress and apoptosis in streptozotocin-induced diabetic rats

(2015) Tomoaki Inoue et al.   ATHEROSCLEROSIS

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism

(2015) David Carling et al.   Cell Metabolism

Pregnancy Induces Resistance to the Anorectic Effect of Hypothalamic Malonyl-CoA and the Thermogenic Effect of Hypothalamic AMPK Inhibition in Female Rats

(2015) Pablo B. Martínez de Morentin et al.   ENDOCRINOLOGY

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

(2015) Elena Doménech et al.   NATURE CELL BIOLOGY

The molecular basis of the antidiabetic action of quercetin in cultured skeletal muscle cells and hepatocytes

(2015) PierreS Haddad et al.   Pharmacognosy Magazine

Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression

(2015) Yimin Shao et al.   Drug Design Development and Therapy

The brain and brown fat

(2014) Cristina Contreras et al.   ANNALS OF MEDICINE

AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

(2014) D. Grahame Hardie   Annual Review of Nutrition

Hypothalamic effects of thyroid hormones on metabolism

(2014) Noelia Martínez-Sánchez et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Central Neural Regulation of Brown Adipose Tissue Thermogenesis and Energy Expenditure

(2014) Shaun F. Morrison et al.   Cell Metabolism

Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

(2014) Pablo B. Martínez de Morentin et al.   Cell Metabolism

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Exendin-4 Alleviates High Glucose-Induced Rat Mesangial Cell Dysfunction through the AMPK Pathway

(2014) Wen-Wei Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

(2014) D. Beiroa et al.   DIABETES

Olanzapine-Activated AMPK Signaling in the Dorsal Vagal Complex Is Attenuated by Histamine H1 Receptor Agonist in Female Rats

(2014) Meng He et al.   ENDOCRINOLOGY

Liraglutide Enhances Insulin Sensitivity by Activating AMP-Activated Protein Kinase in Male Wistar Rats

(2014) Satoru Yamazaki et al.   ENDOCRINOLOGY

Nicotine Improves Obesity and Hepatic Steatosis and ER Stress in Diet-Induced Obese Male Rats

(2014) Patricia Seoane-Collazo et al.   ENDOCRINOLOGY

Liraglutide enhances glucose transporter 4 translocation via regulation of AMP-activated protein kinase signaling pathways in mouse skeletal muscle cells

(2014) Zhu Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

(2014) Brian Finan et al.   NATURE MEDICINE

Glucagon-Like Peptide-1 (GLP-1) Analog Liraglutide Inhibits Endothelial Cell Inflammation through a Calcium and AMPK Dependent Mechanism

(2014) Nadia M. Krasner et al.   PLoS One

Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

(2014) Cristina Contreras et al.   Cell Reports

The LKB1-AMPK Pathway—Friend or Foe in Cancer?

(2013) D. Grahame Hardie   CANCER CELL

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

Olanzapine increases hepatic glucose production through the activation of hypothalamic adenosine 5′-monophosphate-activated protein kinase

(2013) M. Ikegami et al.   DIABETES OBESITY & METABOLISM

Olanzapine induces glucose intolerance through the activation of AMPK in the mouse hypothalamus

(2013) Megumi Ikegami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects

(2013) Silje Skrede et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Energy balance regulation by thyroid hormones at central level

(2013) Miguel López et al.   TRENDS IN MOLECULAR MEDICINE

AMP-activated protein kinase: new regulation, new roles?

(2012) David Carling et al.   BIOCHEMICAL JOURNAL

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase

(2012) P. B. Martinez de Morentin et al.   DIABETES

Targeted estrogen delivery reverses the metabolic syndrome

(2012) Brian Finan et al.   NATURE MEDICINE

Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons

(2012) Marcelo O. Dietrich et al.   NATURE REVIEWS DRUG DISCOVERY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway

(2012) Xin-Yu Miao et al.   PEPTIDES

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

AMP-activated protein kinase: nature's energy sensor

(2011) David Carling et al.   Nature Chemical Biology

Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice

(2011) R. Beltrán-Debón et al.   PHYTOMEDICINE

AMP-activated protein kinase (AMPK)  1 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

(2011) H. M. O'Neill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

AMP-activated protein kinase: also regulated by ADP?

(2011) D. Grahame Hardie et al.   TRENDS IN BIOCHEMICAL SCIENCES

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

RETRACTED ARTICLE: A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells

(2010) Y. Hattori et al.   DIABETOLOGIA

Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender

(2010) Ricardo Lage et al.   FASEB JOURNAL

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of Ghrelin and Growth Hormone Deficiency on AMP-Activated Protein Kinase and Hypothalamic Lipid Metabolism

(2010) S. Sangiao-Alvarellos et al.   JOURNAL OF NEUROENDOCRINOLOGY

Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity

(2010) Jun Lu et al.   JOURNAL OF PATHOLOGY

AMP-activated protein kinase: ‘a cup of tea’ against cholesterol-induced neurotoxicity

(2010) Pablo Blanco Martínez de Morentin et al.   JOURNAL OF PATHOLOGY

The role of hypothalamic AMP-activated protein kinase in ovariectomy-induced obesity in rats

(2010) Yung-Chieh Tsai et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase–acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus

(2010) Jun-Ping Wen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

(2010) Miguel López et al.   NATURE MEDICINE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

“Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress

(2010) Pablo Blanco Martínez de Morentin et al.   PLOS BIOLOGY

Hypothalamic lipotoxicity and the metabolic syndrome

(2009) Pablo B. Martínez de Morentin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer

(2009) S. Fogarty et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

AMP-activated protein kinase promotes human prostate cancer cell growth and survival

(2009) H. U. Park et al.   MOLECULAR CANCER THERAPEUTICS

Nutrition, metabolic factors and cancer risk

(2008) Laure Dossus et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK

(2008) Danna M. Breen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways

(2008) Jiyun Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue

(2008) Jingzong Qi et al.   EMBO JOURNAL

Acute Effects of Glucagon-Like Peptide-1 on Hypothalamic Neuropeptide and AMP Activated Kinase Expression in Fasted Rats

(2008) Sanghee SEO et al.   ENDOCRINE JOURNAL

Central Resistin Regulates Hypothalamic and Peripheral Lipid Metabolism in a Nutritional-Dependent Fashion

(2008) María J. Vázquez et al.   ENDOCRINOLOGY

Glucocorticoids Increase Neuropeptide Y and Agouti-Related Peptide Gene Expression via Adenosine Monophosphate-Activated Protein Kinase Signaling in the Arcuate Nucleus of Rats

(2008) Hiroshi Shimizu et al.   ENDOCRINOLOGY

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

(2008) Daniel Moreno et al.   FEBS LETTERS

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System

(2008) Blerina Kola et al.   PLoS One

AMPK: a metabolic gauge regulating whole-body energy homeostasis

(2008) Ricardo Lage et al.   TRENDS IN MOLECULAR MEDICINE