Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer

(2015) Jia Wei et al.   NATURE

Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes

(2014) David A. Griffith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in the Development of Acetyl-CoA Carboxylase (ACC) Inhibitors for the Treatment of Metabolic Disease

(2014) Matthew P. Bourbeau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diagnosis and Classification of Diabetes Mellitus

(2013)   DIABETES CARE

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

Decreased long-chain fatty acid oxidation impairs postischemic recovery of the insulin-resistant rat heart

(2013) Romain Harmancey et al.   FASEB JOURNAL

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Structure and function of biotin-dependent carboxylases

(2012) Liang Tong   CELLULAR AND MOLECULAR LIFE SCIENCES

Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy

(2012) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Inhibition of acetyl-CoA carboxylase 2 enhances skeletal muscle fatty acid oxidation and improves whole-body glucose homeostasis in db/db mice

(2012) S. Glund et al.   DIABETOLOGIA

Characterization of Fiber Types in Different Muscles of the Hindlimb in Female Weanling and Adult Wistar Rats

(2011) Anabelle Silva Cornachione et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Triglycerides and Cardiovascular Disease

(2011) Michael Miller et al.   CIRCULATION

The adipocyte as an endocrine organ in the regulation of metabolic homeostasis

(2011) H. James Harwood   NEUROPHARMACOLOGY

Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation

(2010) Donald B. Jump et al.   BIOCHEMICAL PHARMACOLOGY

Acute or Chronic Upregulation of Mitochondrial Fatty Acid Oxidation Has No Net Effect on Whole-Body Energy Expenditure or Adiposity

(2010) Kyle L. Hoehn et al.   Cell Metabolism

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake

(2010) D. P. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK

(2009) Yong Soon Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase

(2009) Brian Raymer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

(2009) Jeffrey W. Corbett et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling

Role of the Active-Site Solvent in the Thermodynamics of Factor Xa Ligand Binding

(2008) Robert Abel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY