Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy

Hypoxia induced EMT: A review on the mechanism of tumor progression and metastasis in OSCC

(2018) Joel P. Joseph et al.   ORAL ONCOLOGY

Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies

(2017) Volker H. Haase   EXPERIMENTAL CELL RESEARCH

Oxygen availability and metabolic reprogramming in cancer

(2017) Hong Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is CD47 an innate immune checkpoint for tumor evasion?

(2017) Xiaojuan Liu et al.   Journal of Hematology & Oncology

Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

(2017) Si-Rui Ma et al.   Molecular Cancer

The Role of Hypoxia in Angiogenesis and Extracellular Matrix Regulation of Intervertebral Disc Cells During Inflammatory Reactions

(2017) Woo-Keun Kwon et al.   NEUROSURGERY

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation

(2017) Veronica Huber et al.   SEMINARS IN CANCER BIOLOGY

Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy

(2017) Tianchi Yu et al.   YONSEI MEDICAL JOURNAL

Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells

(2017) Marica Garziera et al.   Journal of Immunology Research

Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors

(2017) Eva M. Palsson-McDermott et al.   Frontiers in Immunology

Adjuvant Weekly Girentuximab Following Nephrectomy for High-Risk Renal Cell Carcinoma

(2017) Karim Chamie et al.   JAMA Oncology

Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8+ T-cell recognition of stressed cells

(2016) Takanori Sasaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export

(2016) Scott K. Parks et al.   MOLECULAR ASPECTS OF MEDICINE

Pharmacological targeting of the HIF hydroxylases – A new field in medicine development

(2016) Mun Chiang Chan et al.   MOLECULAR ASPECTS OF MEDICINE

Hypoxia-Driven Mechanism of Vemurafenib Resistance in Melanoma

(2016) Y. Qin et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2

(2016) Layale Yaghi et al.   Oncotarget

Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer

(2016) Li Ren et al.   Oncotarget

Classical and non-classical HLA class I aberrations in primary cervical squamous- and adenocarcinomas and paired lymph node metastases

(2016) Debbie M. Ferns et al.   Journal for ImmunoTherapy of Cancer

CD47 Promotes Tumor Invasion and Metastasis in Non-small Cell Lung Cancer

(2016) Hui Zhao et al.   Scientific Reports

Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

(2015) Muhammad Zaeem Noman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Predictive value of HLA-G and HLA-E in the prognosis of colorectal cancer patients

(2015) Zhang-Yan Guo et al.   CELLULAR IMMUNOLOGY

Metabolic and mind shifts

(2015) Cyril Corbet et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Expression of lactate/H+ symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses

(2015) Younghye Kim et al.   HUMAN PATHOLOGY

E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity

(2015) Jee H. Lee et al.   IMMUNITY

Effects of extracellular pH and hypoxia on the function and development of antigen-specific cytotoxic T lymphocytes

(2015) Yohko Nakagawa et al.   IMMUNOLOGY LETTERS

AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells

(2015) Dongmei Fan et al.   Journal of Hematology & Oncology

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

(2015) Ibtissam Marchiq et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells

(2015) JongWook Hong et al.   JNCI-Journal of the National Cancer Institute

Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo

(2015) De-Kuan Chang et al.   Molecular Cancer

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

(2015) Huimin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use

(2015) Jaromir Pastorek et al.   SEMINARS IN CANCER BIOLOGY

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells

(2015) JongWook Hong et al.   JNCI-Journal of the National Cancer Institute

Non-classical HLA-class I expression in serous ovarian carcinoma: Correlation with the HLA-genotype, tumor infiltrating immune cells and prognosis

(2015) Emilia Andersson et al.   OncoImmunology

Localized Hypoxia Results in Spatially Heterogeneous Metabolic Signatures in Breast Tumor Models

(2015) Lu Jiang et al.   NEOPLASIA

Targeting hypoxia at the forefront of anticancer immune responses

(2015) Muhammad Zaeem Noman et al.   OncoImmunology

CD47 in the Tumor Microenvironment Limits Cooperation between Antitumor T-cell Immunity and Radiotherapy

(2014) D. R. Soto-Pantoja et al.   CANCER RESEARCH

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New insights into HLA-G mediated tolerance

(2014) G. Amodio et al.   TISSUE ANTIGENS

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors

(2014) Olga Sedlakova   Frontiers in Physiology

A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells

(2013) I. B. Barsoum et al.   CANCER RESEARCH

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

(2013) J. Fan et al.   Molecular Systems Biology

Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment

(2013) A Casazza et al.   ONCOGENE

Metabolic Reprogramming and Validation of Hyperpolarized13C Lactate as a Prostate Cancer Biomarker Using a Human Prostate Tissue Slice Culture Bioreactor

(2013) Kayvan R. Keshari et al.   PROSTATE

pH sensing and regulation in cancer

(2013) Mehdi Damaghi et al.   Frontiers in Physiology

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

(2012) A. Facciabene et al.   CANCER RESEARCH

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Functional distinction of rat liver natural killer cells from spleen natural killer cells under normal and acidic conditions in vitro

(2012) Li-Hong Lv et al.   Hepatobiliary & Pancreatic Diseases International

Human leukocyte antigen-G (HLA-G) expression in cervical cancer lesions is associated with disease progression

(2012) Xiang-Juan Li et al.   HUMAN IMMUNOLOGY

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HLA-G Expression in Cancers: Potential Role in Diagnosis, Prognosis and Therapy

(2012) Wei-Hua Yan   Endocrine Metabolic & Immune Disorders-Drug Targets

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial-Mesenchymal Transition

(2011) Min-Zu Wu et al.   MOLECULAR CELL

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors

(2011) I. Park et al.   NEURO-ONCOLOGY

Lactate MRSI and DCE MRI as surrogate markers of prostate tumor aggressiveness

(2011) J. Yaligar et al.   NMR IN BIOMEDICINE

Carcinoma-Derived Interleukin-8 Disorients Dendritic Cell Migration Without Impairing T-Cell Stimulation

(2011) Carlos Alfaro et al.   PLoS One

CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression

(2010) D. Jin et al.   CANCER RESEARCH

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue

(2010) Thomas Ziebart et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: An unexpected prognostic significance?

(2010) Leos Kren et al.   NEUROPATHOLOGY

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1α, POU/OCT, and NF-κB

(2009) Katoh   INTERNATIONAL JOURNAL OF ONCOLOGY

Development of HIF-1 inhibitors for cancer therapy

(2009) Barbara Onnis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

(2009) K. S. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak

(2008) J. C. Morote-Garcia et al.   BLOOD

Beyond the increasing complexity of the immunomodulatory HLA-G molecule

(2008) E. D. Carosella et al.   BLOOD

Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy

(2008) Suja Saraswathy et al.   JOURNAL OF NEURO-ONCOLOGY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Association of CD47 with Natural Killer Cell-Mediated Cytotoxicity of Head-and-Neck Squamous Cell Carcinoma Lines

(2008) Min Jung Kim et al.   TUMOR BIOLOGY