Drug Repositioning of Proton Pump Inhibitors for Enhanced Efficacy and Safety of Cancer Chemotherapy

The Function of V-ATPases in Cancer

(2016) Laura Stransky et al.   PHYSIOLOGICAL REVIEWS

Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma

(2015) Yoo-Young Lee et al.   Oncotarget

Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates

(2015) Kristina Hacker et al.   PLoS One

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis

(2015) Regina M. Graham et al.   Oncotarget

Retrospective evaluation of methotrexate elimination when co-administered with proton pump inhibitors

(2014) David J. Reeves et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The effect of lansoprazole, an OCT inhibitor, on metformin pharmacokinetics in healthy subjects

(2013) Yi Ding et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Silencing of Atp6v1c1 Prevents Breast Cancer Growth and Bone Metastasis

(2013) Shengmei Feng et al.   International Journal of Biological Sciences

Prevalence of Acid-Reducing Agents (ARA) in Cancer Populations and ARA Drug–Drug Interaction Potential for Molecular Targeted Agents in Clinical Development

(2013) Gillian S. Smelick et al.   MOLECULAR PHARMACEUTICS

Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors

(2013) Jai Moo Shin et al.   Journal of Neurogastroenterology and Motility

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

(2011) Atsushi Yonezawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)

(2011) Anne T. Nies et al.   PLoS One

Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity

(2010) Takanori Nakamura et al.   BIOCHEMICAL PHARMACOLOGY

Organic cation transporter OCT/SLC22A and H+/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents

(2010) Atsushi Yonezawa et al.   BIOCHEMICAL PHARMACOLOGY

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

(2009) Angelo De Milito et al.   INTERNATIONAL JOURNAL OF CANCER

Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy

(2008) Kunihiro Suzuki et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL