Heparanase in inflammation and inflammation-associated cancer

Pharmacological Inhibition of DNA Methylation Induces Proinvasive and Prometastatic Genes In Vitro and In Vivo

(2015) Bushra Ateeq et al.   NEOPLASIA

Induction of Heparanase-1 Expression by Mutant B-Raf Kinase: Role of GA Binding Protein in Heparanase-1 Promoter Activation

(2015) Geetha Rao et al.   NEOPLASIA

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain

(2012) Xiao Zhang et al.   ACTA NEUROPATHOLOGICA

Macrophage Activation by Heparanase Is Mediated by TLR-2 and TLR-4 and Associates With Plaque Progression

(2012) Miry Blich et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased expression of heparanase in symptomatic carotid atherosclerosis

(2012) C. Österholm et al.   ATHEROSCLEROSIS

Heparanase enzyme in chronic inflammatory bowel disease and colon cancer

(2012) Esther Hermano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Barrett’s to Oesophageal Cancer Sequence: A Model of Inflammatory-Driven Upper Gastrointestinal Cancer

(2012) Sarah L. Picardo et al.   DIGESTIVE SURGERY

Inflammation-Associated Cancer Development in Digestive Organs: Mechanisms and Roles for Genetic and Epigenetic Modulation

(2012) Tsutomu Chiba et al.   GASTROENTEROLOGY

Heparanase Enhances the Insulin Receptor Signaling Pathway to Activate Extracellular Signal-regulated Kinase in Multiple Myeloma

(2012) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice

(2012) Lili Li et al.   NEUROSCIENCE LETTERS

Small RNAs Targeting Transcription Start Site Induce Heparanase Silencing through Interference with Transcription Initiation in Human Cancer Cells

(2012) Guosong Jiang et al.   PLoS One

Elevated Urine Heparanase Levels Are Associated with Proteinuria and Decreased Renal Allograft Function

(2012) Itay Shafat et al.   PLoS One

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

(2011) K Dredge et al.   BRITISH JOURNAL OF CANCER

Role of Heparanase in Radiation-Enhanced Invasiveness of Pancreatic Carcinoma

(2011) A. Meirovitz et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

(2011) N. Gil et al.   DIABETES

Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis

(2011) G. Rao et al.   DIABETOLOGIA

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

(2011) Immanuel Lerner et al.   JOURNAL OF CLINICAL INVESTIGATION

Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes

(2011) Andrew F. Ziolkowski et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated

(2011) Hamid Akbarshahi et al.   Journal of Translational Medicine

M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis

(2011) He Zhou et al.   PLoS One

Genetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donors

(2010) O. Ostrovsky et al.   BLOOD

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis

(2010) A. Purushothaman et al.   BLOOD

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

(2010) Achilleas D. Theocharis et al.   FEBS Journal

Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett’s oesophagus and intestinal-type gastric carcinoma

(2010) Ryotaro Sonoda et al.   HISTOPATHOLOGY

Heparanase 2 Interacts with Heparan Sulfate with High Affinity and Inhibits Heparanase Activity

(2010) Flonia Levy-Adam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity

(2010) Vishnu C. Ramani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pre-clinical and clinical significance of heparanase in Ewing’s sarcoma

(2010) Itay Shafat et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Enoxaparin Improves the Course of Dextran Sodium Sulfate-Induced Colitis in Syndecan-1-Deficient Mice

(2009) Martin Floer et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation and oncogenesis: a vicious connection

(2009) Sergei I Grivennikov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression

(2009) Rita Brun et al.   MODERN PATHOLOGY

Regulation of glomerular heparanase expression by aldosterone, angiotensin II and reactive oxygen species

(2009) M. J. van den Hoven et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix Metalloproteinases

(2009) Eyal Zcharia et al.   PLoS One

Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis

(2008) Rachel W. Li et al.   ARTHRITIS AND RHEUMATISM

Heparanase Augments Epidermal Growth Factor Receptor Phosphorylation: Correlation with Head and Neck Tumor Progression

(2008) V. Cohen-Kaplan et al.   CANCER RESEARCH

Heparanase Alters Arterial Structure, Mechanics, and Repair Following Endovascular Stenting in Mice

(2008) Aaron B. Baker et al.   CIRCULATION RESEARCH

Function of Heparanase in Prostate Tumorigenesis: Potential for Therapy

(2008) I. Lerner et al.   CLINICAL CANCER RESEARCH

Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment

(2008) Ghada Abboud-Jarrous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function

(2008) Lars Bode et al.   JOURNAL OF CLINICAL INVESTIGATION

High Expression of Heparanase is Significantly Associated with Dedifferentiation and Lymph Node Metastasis in Patients with Pancreatic Ductal Adenocarcinomas and Correlated to PDGFA and Via HIF1a to HB-EGF and bFGF

(2008) Andreas-Claudius Hoffmann et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

The anti-inflammatory effects of heparin and related compounds

(2007) Edward Young   THROMBOSIS RESEARCH