Teaming Up for Trouble: Cancer Cells, Transforming Growth Factor-β1 Signaling and the Epigenetic Corruption of Stromal Naïve Fibroblasts

DNA methylation in the tumor microenvironment

(2017) Meng-wen Zhang et al.   Journal of Zhejiang University-SCIENCE B

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

(2017) Huipeng Li et al.   NATURE GENETICS

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer

(2017) Takao Fujisawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis

(2017) Michael J. Bollong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal cues regulate the pancreatic cancer epigenome and metabolome

(2017) Mara H. Sherman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility

(2017) Erine H. Budi et al.   TRENDS IN CELL BIOLOGY

TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment

(2017) Michael W. Pickup et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Family Signaling in Tumor Suppression and Cancer Progression

(2017) Joan Seoane et al.   Cold Spring Harbor Perspectives in Biology

Targeting TGF-β Signaling for Therapeutic Gain

(2017) Rosemary J. Akhurst   Cold Spring Harbor Perspectives in Biology

Targeting Cancer Cells with BET Bromodomain Inhibitors

(2017) Yali Xu et al.   Cold Spring Harbor Perspectives in Medicine

Tumor Microenvironment and Differential Responses to Therapy

(2017) Eishu Hirata et al.   Cold Spring Harbor Perspectives in Medicine

Stromal Modulators of TGF-β in Cancer

(2017) Brunella Costanza et al.   Journal of Clinical Medicine

Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment

(2016) Genichiro Ishii et al.   ADVANCED DRUG DELIVERY REVIEWS

Human Colorectal Cancer Stage-dependent Global DNA Hypomethylation of Cancer-associated Fibroblasts

(2016) EDUARD LING et al.   ANTICANCER RESEARCH

Vitamin D and Myofibroblasts in Fibrosis and Cancer: At Cross-purposes with TGF-β/SMAD Signaling

(2016) SHRAGA SHANY et al.   ANTICANCER RESEARCH

Expression profiling of budding cells in colorectal cancer reveals an EMT-like phenotype and molecular subtype switching

(2016) Linde De Smedt et al.   BRITISH JOURNAL OF CANCER

Tumor microenvironment and cancer therapy resistance

(2016) Yu Sun   CANCER LETTERS

Cancer-Associated Fibroblasts in Pancreatic Cancer Are Reprogrammed by Tumor-Induced Alterations in Genomic DNA Methylation

(2016) Qian Xiao et al.   CANCER RESEARCH

Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors

(2016) Lei Miao et al.   CANCER RESEARCH

BET Bromodomain as a Target of Epigenetic Therapy

(2016) Tomomi Noguchi-Yachide   CHEMICAL & PHARMACEUTICAL BULLETIN

Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions

(2016) Jennifer Alexander et al.   CURRENT OPINION IN CELL BIOLOGY

CAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumor suppressor deficiency-related changes in healthy tissue

(2016) Anna Etzold et al.   Epigenetics

Breast cancer carcinoma-associated fibroblasts differ from breast fibroblasts in immunological and extracellular matrix regulating pathways

(2016) I. Pasanen et al.   EXPERIMENTAL CELL RESEARCH

Myofibroblasts

(2016) Boris Hinz   EXPERIMENTAL EYE RESEARCH

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations

(2016) D. Bianchi-Frias et al.   MOLECULAR CANCER RESEARCH

Tumor suppressor bromodomain-containing protein 7 cooperates with Smads to promote transforming growth factor-β responses

(2016) T Liu et al.   ONCOGENE

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease

(2016) FuiBoon Kai et al.   TRENDS IN CELL BIOLOGY

Caveolae: One Function or Many?

(2016) Jade P.X. Cheng et al.   TRENDS IN CELL BIOLOGY

Histone Modifications and Cancer

(2016) James E. Audia et al.   Cold Spring Harbor Perspectives in Biology

Transcriptional Control by the SMADs

(2016) Caroline S. Hill   Cold Spring Harbor Perspectives in Biology

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

Posttranslational Regulation of Smads

(2016) Pinglong Xu et al.   Cold Spring Harbor Perspectives in Biology

Regulation of TGF-β Family Signaling by Inhibitory Smads

(2016) Keiji Miyazawa et al.   Cold Spring Harbor Perspectives in Biology

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

(2016) Ian B. Robertson et al.   Cold Spring Harbor Perspectives in Biology

Epigenetic control of the tumor microenvironment

(2016) David L Marks et al.   Epigenomics

Genetic alterations and epigenetic alterations of cancer-associated fibroblasts

(2016) Heng Du et al.   Oncology Letters

Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer

(2016) Keisuke Yamamoto et al.   Oncotarget

TGF-β1 epigenetically modifies Thy-1 expression in primary lung fibroblasts

(2015) Wendy A. Neveu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

New horizons in tumor microenvironment biology: challenges and opportunities

(2015) Fei Chen et al.   BMC Medicine

Orchestrating the Tumor Microenvironment to Improve Survival for Patients With Pancreatic Cancer

(2015) Clifford J. Whatcott et al.   CANCER JOURNAL

Aberrant DNA methylation in non-small cell lung cancer-associated fibroblasts

(2015) Miguel Vizoso et al.   CARCINOGENESIS

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

Procollagen Lysyl Hydroxylase 2 Expression Is Regulated by an Alternative Downstream Transforming Growth Factor β-1 Activation Mechanism

(2015) Rutger A. F. Gjaltema et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

(2015) Alexandre Calon et al.   NATURE GENETICS

Stromal contribution to the colorectal cancer transcriptome

(2015) Claudio Isella et al.   NATURE GENETICS

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

Versican V1 Overexpression Induces a Myofibroblast-Like Phenotype in Cultured Fibroblasts

(2015) Jon M. Carthy et al.   PLoS One

The impact of tumor stroma on drug response in breast cancer

(2015) Jürgen Dittmer et al.   SEMINARS IN CANCER BIOLOGY

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

(2015) Ruchi Malik et al.   TRENDS IN BIOTECHNOLOGY

Microenvironmental regulation of therapeutic response in cancer

(2015) Florian Klemm et al.   TRENDS IN CELL BIOLOGY

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

COL11A1/(pro)collagen 11A1 expression is a remarkable biomarker of human invasive carcinoma-associated stromal cells and carcinoma progression

(2015) Fernando Vázquez-Villa et al.   TUMOR BIOLOGY

Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics

(2015) Elly De Vlieghere et al.   VIRCHOWS ARCHIV

Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts

(2015) Jean Albrengues et al.   Nature Communications

Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery

(2015) Lei-lei Fu et al.   Oncotarget

Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation

(2015) Daoxiang Zhang et al.   Cell Reports

Remodeling Components of the Tumor Microenvironment to Enhance Cancer Therapy

(2015) Vasiliki Gkretsi et al.   Frontiers in Oncology

SMAD-Independent Down-Regulation of Caveolin-1 by TGF-β: Effects on Proliferation and Survival of Myofibroblasts

(2015) Yan Y. Sanders et al.   PLoS One

Interpreting the language of histone and DNA modifications

(2014) Scott B. Rothbart et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Validation of COL11A1/procollagen 11A1 expression in TGF-β1-activated immortalised human mesenchymal cells and in stromal cells of human colon adenocarcinoma

(2014) José A Galván et al.   BMC CANCER

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Sequence Artifacts in DNA from Formalin-Fixed Tissues: Causes and Strategies for Minimization

(2014) H. Do et al.   CLINICAL CHEMISTRY

Lysine post-translational modifications of collagen

(2014) Mitsuo Yamauchi et al.   Essays in Biochemistry

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prognostic relevance of cancer-associated fibroblasts in human cancer

(2014) Janna Paulsson et al.   SEMINARS IN CANCER BIOLOGY

TGF-beta in CAF-mediated tumor growth and metastasis

(2014) A. Calon et al.   SEMINARS IN CANCER BIOLOGY

LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer

(2014) Jean Albrengues et al.   Cell Reports

TGF-  Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment

(2013) T.-L. Yeung et al.   CANCER RESEARCH

Functional Heterogeneity of Cancer-Associated Fibroblasts from Human Colon Tumors Shows Specific Prognostic Gene Expression Signature

(2013) M. Herrera et al.   CLINICAL CANCER RESEARCH

Carcinoma-associated fibroblasts: Non-neoplastic tumour-promoting mesenchymal cells

(2013) Urszula M. Polanska et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

The role of tumour–stromal interactions in modifying drug response: challenges and opportunities

(2013) Douglas W. McMillin et al.   NATURE REVIEWS DRUG DISCOVERY

Transforming Growth Factor β1 Induces the Expression of Collagen Type I by DNA Methylation in Cardiac Fibroblasts

(2013) Xiaodong Pan et al.   PLoS One

‘Cancer associated fibroblasts’ – more than meets the eye

(2013) Shalom Madar et al.   TRENDS IN MOLECULAR MEDICINE

Carcinoma-Associated Fibroblasts Are a Promising Therapeutic Target

(2013) Shinsaku Togo et al.   Cancers

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non-Small Cell Lung Cancer In Vivo

(2012) S. Vicent et al.   CANCER RESEARCH

Hypomethylating Therapy in an Aggressive Stroma-Rich Model of Pancreatic Carcinoma

(2012) R. Shakya et al.   CANCER RESEARCH

Stromal biomarkers in breast cancer development and progression

(2012) Jenny A. Rudnick et al.   CLINICAL & EXPERIMENTAL METASTASIS

Folic Acid Increases Global DNA Methylation and Reduces Inflammation to Prevent Helicobacter-Associated Gastric Cancer in Mice

(2012) Tamas A. Gonda et al.   GASTROENTEROLOGY

The expression of the high-mobility group A2 protein in colorectal cancer and surrounding fibroblasts is linked to tumor invasiveness

(2012) Claudio Rizzi et al.   HUMAN PATHOLOGY

The Origin of Stroma Surrounding Epithelial Ovarian Cancer Cells

(2012) Tomoko Akahane et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

Differences in transcriptional effects of 1α,25 dihydroxyvitamin D3 on fibroblasts associated to breast carcinomas and from paired normal breast tissues

(2012) Laura Tojeiro Campos et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Genomic (In)stability of the Breast Tumor Microenvironment

(2012) S. Rummel et al.   MOLECULAR CANCER RESEARCH

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Breast Cancer Cells Induce Stromal Fibroblasts to Secrete ADAMTS1 for Cancer Invasion through an Epigenetic Change

(2012) Shiaw-Wei Tyan et al.   PLoS One

Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling

(2012) Y. Zong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk between TGF-β signaling and the microRNA machinery

(2012) Henriett Butz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Cervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations

(2011) Willem Ernst Corver et al.   CELLULAR ONCOLOGY

Epigenetic Regulation of Myofibroblast Differentiation by DNA Methylation

(2010) Biao Hu et al.   AMERICAN JOURNAL OF PATHOLOGY

HMGA and Cancer

(2010) Monica Fedele et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Pancreatic cancer associated fibroblasts display normal allelotypes

(2010) Kimberly Walter et al.   CANCER BIOLOGY & THERAPY

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Breast Carcinoma-Associated Fibroblasts Rarely Contain p53 Mutations or Chromosomal Aberrations

(2010) A. N. Hosein et al.   CANCER RESEARCH

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing

(2010) Coert Margadant et al.   EMBO REPORTS

Genetic changes in tumour microenvironments

(2010) Ian Campbell et al.   JOURNAL OF PATHOLOGY

The Collagen Family

(2010) S. Ricard-Blum   Cold Spring Harbor Perspectives in Biology

Abrogation of TGF-β1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition

(2009) Weichao Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Clonal Mutations in the Cancer-Associated Fibroblasts: The Case against Genetic Coevolution

(2009) I. Campbell et al.   CANCER RESEARCH

Active TGF-β1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence

(2009) Lukas J. A. C. Hawinkels et al.   CANCER SCIENCE

Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy?

(2009) Tamas A. Gonda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of Stromal Fibroblasts in Cancer: Promoting or Impeding?

(2009) Flora Angeli et al.   TUMOR BIOLOGY

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Global Hypomethylation of Genomic DNA in Cancer-Associated Myofibroblasts

(2008) L. Jiang et al.   CANCER RESEARCH

Transforming Growth Factor β1 Induces αvβ3 Integrin Expression in Human Lung Fibroblasts via a β3 Integrin-, c-Src-, and p38 MAPK-dependent Pathway

(2008) Dmitri V. Pechkovsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas

(2008) Wen Qiu et al.   NATURE GENETICS

Co-evolution of tumor cells and their microenvironment

(2008) Kornelia Polyak et al.   TRENDS IN GENETICS