Tumor-related interleukins: old validated targets for new anti-cancer drug development
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Title
Tumor-related interleukins: old validated targets for new anti-cancer drug development
Authors
Keywords
Cancer, Tumor microenvironment, Immune cells, Cytokines, Anti-cancer
Journal
Molecular Cancer
Volume 16, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-09-19
DOI
10.1186/s12943-017-0721-9
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- (2017) Stephanie Tsang Mui Chung et al. Molecular Cancer
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- (2016) Siri Tähtinen et al. JOURNAL OF IMMUNOTHERAPY
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- (2016) Xijuan Chen et al. JOURNAL OF ORAL PATHOLOGY & MEDICINE
- The JAK inhibitor ruxolitinib impairs dendritic cell migration via off-target inhibition of ROCK
- (2016) J Rudolph et al. LEUKEMIA
- Interleukin-1β increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model
- (2016) FUNG-YU HUANG et al. Oncology Letters
- IL-1 drives breast cancer growth and bone metastasis in vivo
- (2016) Ingunn Holen et al. Oncotarget
- Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer
- (2016) Tae-Hwe Heo et al. Oncotarget
- Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice
- (2016) Jing Hong et al. Scientific Reports
- The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome
- (2016) Lotte Pyfferoen et al. OncoImmunology
- Deciphering the Cellular Targets of Bioactive Compounds Using a Chloroalkane Capture Tag
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- Synergistic Innate and Adaptive Immune Response to Combination Immunotherapy with Anti-Tumor Antigen Antibodies and Extended Serum Half-Life IL-2
- (2015) Eric F. Zhu et al. CANCER CELL
- Intralesional administration of L19-IL2/L19-TNF in stage III or stage IVM1a melanoma patients: results of a phase II study
- (2015) Riccardo Danielli et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Targeting IL4/IL4R for the treatment of epithelial cancer metastasis
- (2015) Katherine Venmar Bankaitis et al. CLINICAL & EXPERIMENTAL METASTASIS
- TAMS and IL-6 contribute to resistance to radiotherapy in oral squamous cell carcinoma
- (2015) Y. Matsuoka et al. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
- Lewis Lung Cancer Cells Promote SIGNR1(CD209b)-Mediated Macrophages Polarization Induced by IL-4 to Facilitate Immune Evasion
- (2015) Xiaolong Yan et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3′-diindolylmethane in ovarian cancer cells
- (2015) Minghua Zou et al. CELLULAR ONCOLOGY
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- (2014) Y. Xu et al. BLOOD
- IL4 Receptor ILR4 Regulates Metastatic Colonization by Mammary Tumors through Multiple Signaling Pathways
- (2014) K. T. Venmar et al. CANCER RESEARCH
- Therapeutic DC vaccination with IL-2 as a consolidation therapy for ovarian cancer patients: a phase I/II trial
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- Interleukin-6 and its receptors: A highly regulated and dynamic system
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- The IL-2 cytokine family in cancer immunotherapy
- (2014) Geok Choo Sim et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Siltuximab: First Global Approval
- (2014) Anthony Markham et al. DRUGS
- Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells
- (2014) Shanshan Wan et al. GASTROENTEROLOGY
- The origin of cancer stem cells
- (2014) Hien T. Dang et al. JOURNAL OF HEPATOLOGY
- IL-2: The First Effective Immunotherapy for Human Cancer
- (2014) S. A. Rosenberg JOURNAL OF IMMUNOLOGY
- Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis
- (2014) Lisa A. Beck et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2014) B. Weide et al. Cancer Immunology Research
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- (2013) Daniel P. Nguyen et al. BJU INTERNATIONAL
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- (2013) E Rettinger et al. BONE MARROW TRANSPLANTATION
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- (2013) S Mitsunaga et al. BRITISH JOURNAL OF CANCER
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- (2013) T Nagasaki et al. BRITISH JOURNAL OF CANCER
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- (2011) Douglas J. Schwartzentruber et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2011) A. Fettelschoss et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2010) Matthew E. Pipkin et al. IMMUNITY
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- (2009) I. D. Davis et al. CLINICAL CANCER RESEARCH
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- (2009) M. Fulciniti et al. CLINICAL CANCER RESEARCH
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- (2008) C. S. Hinrichs et al. BLOOD
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- IL-1 trap go-ahead
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- (2007) Thomas R. Malek Annual Review of Immunology
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