Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models
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Title
Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models
Authors
Keywords
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Journal
Disease Models & Mechanisms
Volume 12, Issue 2, Pages dmm037051
Publisher
The Company of Biologists
Online
2019-02-04
DOI
10.1242/dmm.037051
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- WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways
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- Porcupine-mediated lipidation is required for Wnt recognition by Wls
- (2011) Patrick Herr et al. DEVELOPMENTAL BIOLOGY
- A Conserved Pbx-Wnt-p63-Irf6 Regulatory Module Controls Face Morphogenesis by Promoting Epithelial Apoptosis
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- Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development
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- A novel mechanism for the transcriptional regulation of Wnt signaling in development
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- Mutation update for the PORCN gene
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- p63 Regulates Human Keratinocyte Proliferation via MYC-regulated Gene Network and Differentiation Commitment through Cell Adhesion-related Gene Network
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- Sequential Activation and Inactivation of Dishevelled in the Wnt/β-Catenin Pathway by Casein Kinases
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- Fibroblast Growth Factor 9 (FGF9)-Pituitary Homeobox 2 (PITX2) Pathway Mediates Transforming Growth Factor β (TGFβ) Signaling to Regulate Cell Proliferation in Palatal Mesenchyme during Mouse Palatogenesis
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- Contribution of MSX1 variants to the risk of non-syndromic cleft lip and palate in a Malay population
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- Cleft lip and palate: understanding genetic and environmental influences
- (2011) Michael J. Dixon et al. NATURE REVIEWS GENETICS
- The mechanism of TGF-β signaling during palate development
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- Role of GSK-3β in the Osteogenic Differentiation of Palatal Mesenchyme
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- Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome
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- Planar cell polarity signaling in craniofacial development
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- Cranial neural crest cells on the move: Their roles in craniofacial development
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- Association of Wnt3A gene variants with non-syndromic cleft lip with or without cleft palate in Chinese population
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- Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling
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- Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate
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- Studies with Wnt genes and nonsyndromic cleft lip and palate
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- Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications
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- Association between TGFB3 and Nonsyndromic Cleft Lip with or Without Cleft Palate in a Chilean Population
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- Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes
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- Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2
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- Dicer is required for survival of differentiating neural crest cells
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- Regional neural tube closure defined by the Grainy head-like transcription factors
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- Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis
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- Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression
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- Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation
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- The canonical Wnt/ß-catenin signaling pathway regulates Fgf signaling for early facial development
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- Regulation of Tbx22 during facial and palatal development
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- Stickler syndrome caused by COL2A1 mutations: genotype–phenotype correlation in a series of 100 patients
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- Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice
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- Zebrafish wnt9a is expressed in pharyngeal ectoderm and is required for palate and lower jaw development
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- Wnt Trafficking: New Insights into Wnt Maturation, Secretion and Spreading
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- Wnt signal transduction pathways
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- Craniofacial malformation in R-spondin2 knockout mice
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- Genome-Wide Promoter Analysis of the SOX4 Transcriptional Network in Prostate Cancer Cells
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- Dishevelled: The hub of Wnt signaling
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- Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice
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- Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth
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- The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction
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- The Wnt antagonists Frzb-1 and Crescent locally regulate basement membrane dissolution in the developing primary mouth
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- Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion
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- Hand2 is required in the epithelium for palatogenesis in mice
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- New directions in craniofacial morphogenesis
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- Hoxa2plays a direct role in murine palate development
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- Generation of Lrp6 conditional gene-targeting mouse line for modeling and dissecting multiple birth defects/congenital anomalies
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- WNT5Amutations in patients with autosomal dominant Robinow syndrome
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- Visualizing canonical Wnt signaling during mouse craniofacial development
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- Expression of WNT signalling pathway genes during chicken craniofacial development
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- Effect of retinoic acid signaling on Wnt/β-catenin and FGF signaling during body axis extension
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- Wnt signaling pathways meet Rho GTPases
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- Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis
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- Prevalence and nonrandom distribution of exonic mutations in interferon regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome
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- Tbx22 null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes
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- Expression of Wnts in the developing murine secondary palate
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- Wnt/β-Catenin and Retinoic Acid Receptor Signaling Pathways Interact to Regulate Chondrocyte Function and Matrix Turnover
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- Activity of the β-catenin phosphodestruction complex at cell–cell contacts is enhanced by cadherin-based adhesion
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- BMP-2 modulates β-catenin signaling through stimulation ofLrp5expression and inhibition of β-TrCP expression in osteoblasts
- (2009) Ming Zhang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Epithelial-specific requirement of FGFR2 signaling during tooth and palate development
- (2009) Ryoichi Hosokawa et al. JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
- Wnt5a Knock-out Mouse as a New Model of Anorectal Malformation
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- Cleft lip and palate
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- Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
- (2009) Elisabeth Mangold et al. NATURE GENETICS
- SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate
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- Mouse genetic models of cleft lip with or without cleft palate
- (2008) Diana M. Juriloff et al. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
- AXIN2andCDH1polymorphisms, tooth agenesis, and oral clefts
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- Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation
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- Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development
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- Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling
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- Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development
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- Wnt5a is essential for intestinal elongation in mice
- (2008) Sara Cervantes et al. DEVELOPMENTAL BIOLOGY
- Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice
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- Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development
- (2008) Xi Huang et al. DEVELOPMENTAL DYNAMICS
- Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate
- (2008) Brett T. Chiquet et al. HUMAN MOLECULAR GENETICS
- Genomic stability and tumour suppression by the APC/C cofactor Cdh1
- (2008) Irene García-Higuera et al. NATURE CELL BIOLOGY
- Disruption of an AP-2α binding site in an IRF6 enhancer is associated with cleft lip
- (2008) Fedik Rahimov et al. NATURE GENETICS
- MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
- (2008) Johann K Eberhart et al. NATURE GENETICS
- Tissue Engineering in Cleft Palate and Other Congenital Malformations
- (2008) Nicholas J Panetta et al. PEDIATRIC RESEARCH
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