Journal
ORGANOGENESIS
Volume 7, Issue 4, Pages 255-259Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/org.7.4.18797
Keywords
planar cell polarity; craniofacial development; cranial neural crest; skull formation; Wnt pathways; glypicans
Funding
- National Institutes of Health-NIDCR [R01DE016678, F32DE019058, F32DE019986]
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Out of the several signaling pathways controlling craniofacial development, the role of planar cell polarity (PCP) signaling is relatively poorly understood. This pathway, originally identified as a mechanism to maintain cell polarity within the epithelial cells of the Drosophila wing, has been linked to the proper development of a wide variety of tissues in vertebrates and invertebrates. While many of the pathway members are conserved, it appears that some of the members of the pathway act in a tissue-specific manner. Here, we discuss the role of this pathway in vertebrate craniofacial development, highlighting cranial neural crest migration, skull and palate formation and the role of non-traditional modulators of PCP signaling within this developmental process.
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