Review
Biochemistry & Molecular Biology
Chihiro Iwaya, Akiko Suzuki, Junichi Iwata
Summary: Cleft lip and palate is a common congenital birth defect with varied causes. Recent studies suggest that non-coding RNAs, specifically microRNAs, may play a role in the development of cleft lip and palate. This review examines the potential of microRNAs as causative mechanisms in humans and mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
R. H. W. Lacerda, A. R. Vieira
Summary: This study analyzed the genetic and dental anomalies as predictors of maxillofacial growth in patients with cleft lip and palate. The results showed an association between dental anomalies and genetic variations in MMP2, GLI2, TGFA, and FGFR2 with maxillofacial growth outcomes.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Chin-Han Chang, Chi-Hua Chang, Jui-Pin Lai, Shiu-Shiung Lin, Yu-Jen Chang
Summary: This study investigated the prevalence of tooth agenesis, tooth malformation, and eruption patterns of upper canines/first premolars in Taiwanese children. The results suggest a strong correlation between the patterns of dental anomalies and the cleft sites in cleft lip and cleft palate patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Theodosia Bartzela, Bjoern Theuerkauf, Elisabeth Reichardt, Malte Spielmann, Charlotte Opitz
Summary: The study clinically characterized patients and family members with cleft lip and/or palate and associated congenital malformations or syndromes, proposing possible inheritance patterns. Results showed that there was individual and interfamilial phenotypic variability in patients with CL/P, making understanding of etiopathogenesis challenging.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Biochemistry & Molecular Biology
Lucas Alvizi, Luciano Abreu Brito, Gerson Shigeru Kobayashi, Barbara Bischain, Camila Bassi Fernandes da Silva, Sofia Ligia Guimaraes Ramos, Jaqueline Wang, Maria Rita Passos-Bueno
Summary: This study explores the functional effects of epigenetic changes associated with non-syndromic cleft lip with or without cleft palate (NSCLP). The researchers found that a region in the mir152 gene is frequently hypomethylated in NSCLP patients, leading to mir152 overexpression and downregulation of certain genes. They also discovered that mir152 upregulation in zebrafish embryos impairs craniofacial cartilage. Additionally, they propose that hypoxia during embryonic development may contribute to the hypomethylation and upregulation of mir152, leading to NSCLP.
Review
Dentistry, Oral Surgery & Medicine
Kavita Wadde, Asha Chowdhar, Lakshmi Venkatakrishnan, Monali Ghodake, Sanpreet Singh Sachdev, Ashwini Chhapane
Summary: This study aims to identify clinical decisions for the treatment of cleft lip and palate (CLP) patients based on randomized controlled trials. The findings suggest that early initiation of nasoalveolar molding (NAM) in neonatal life has great benefits. More multicenter collaborations are needed to determine the ideal surgical technique and ensure evidence-based treatment for patients.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2023)
Article
Cell Biology
Anna Siewert, Benedikt Reiz, Carina Krug, Julia Heggemann, Elisabeth Mangold, Henning Dickten, Kerstin U. Ludwig
Summary: Cleft lip +/- cleft palate (CL/P) is a common birth defect. Single-cell RNA sequencing (scRNA-seq) data from embryonic mice were used to study gene expression patterns and investigate CL/P candidate genes. The study demonstrates the value of scRNA-seq data in craniofacial research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Surgery
Amy S. Xue, Edward P. Buchanan, Larry H. Hollier
Summary: This article provides an overview of characteristics of unilateral cleft lip and nasal deformity, as well as its management options including presurgical orthopedics, operative techniques, and postsurgical care. Specific surgical techniques such as rotation-advancement and straightline repairs are discussed in detail, along with current concepts in primary cleft nose repair.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Mohammad Khursheed Alam, Ahmed Ali Alfawzan, Fatema Akhter, Haytham Jamil Alswairki, Prabhat Kumar Chaudhari
Summary: This study investigated the variation between non-syndromic cleft lip and/or palate (NSCLP) and non-cleft (NC) subjects in relation to lip morphology (LM) and nasolabial angle (NLA). The results showed significant disparities in LM-1 and NLA between NSCLP and NC individuals.
APPLIED SCIENCES-BASEL
(2022)
Review
Medicine, General & Internal
Harnoor Dhillon, Prabhat Kumar Chaudhari, Kunaal Dhingra, Rong-Fu Kuo, Ramandeep Kaur Sokhi, Mohammad Khursheed Alam, Shandar Ahmad
Summary: This scoping review explores the application of artificial intelligence in aiding individuals with cleft lip and/or palate, mainly focusing on speech therapy. The study highlights the potential and interest in using AI in cleft lip and/or palate, and suggests that multi-center collaborative research may enhance the development of this technology.
FRONTIERS IN MEDICINE
(2021)
Article
Surgery
Amy S. Xue, Edward P. Buchanan, Larry H. Hollier
Summary: This article describes the characteristics and management of bilateral cleft lip and nasal deformity, including presurgical orthopedics, operative techniques, and postsurgical care.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Robert Frederick, Amy Claire Hogan, Natalie Seabolt, Rose Mary S. Stocks
Summary: This article emphasizes the benefits of a multidisciplinary team approach in the systemic management of patients with cleft lip and cleft palate, and suggests the addition of a registered dietitian to the care team. An ideal cleft palate care team should focus on a comprehensive, collaborative, and family-centered approach. While care teams may vary depending on context and location, there are still some key principles.
Review
Dentistry, Oral Surgery & Medicine
Gabriela Fonseca-Souza, Luiza Becker de Oliveira, Leticia Maira Wambier, Rafaela Scariot, Juliana Feltrin-Souza
Summary: Individuals with orofacial clefts are more likely to have tooth abnormalities compared to those without clefts. The type and laterality of the clefts are associated with different types of tooth abnormalities. However, the quality of evidence in the studies is low.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Samantha Gee, Maryam Ezzeldin, Jacob Curtis, Victoria J. Clark, Jacqueline Smallridge, Mechelle Collard
Summary: This study investigates the prevalence of medical conditions affecting patients with cleft lip and/or palate in three cleft units in the UK. The results showed that 38.9% of patients had associated medical conditions. The study highlights the impact of these medical conditions on dental care complexity for these patients.
BRITISH DENTAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Natalia Kaczorowska, Marcin Mikulewicz
Summary: This paper examines cephalometric parameters in patients with cleft lip and palate and cleft lip, and compares the differences between these patient groups. The results show that cleft palate surgery has an effect on the forward growth of the maxilla.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Grace M. De Souza, Tamanna Tiwari, Christopher H. Fox, Patricia A. Miguez, Ariadne Letra, Maria L. Geisinger, Mangala Patel, Luciana Shaddox, Effie Ioannidou
Summary: This study investigated the impact of the COVID-19 pandemic on research productivity, work-life arrangements, and mental health of dental professionals worldwide. The findings revealed that younger individuals and women were disproportionately affected, and institutional support played a crucial role in mitigating the effects of the pandemic.
JOURNAL OF DENTAL EDUCATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leticia Chaves de Souza, Glaucia Schuindt Teixeira Neves, Timothy Kirkpatrick, Ariadne Letra, Renato Silva
Summary: This study evaluated the physicochemical and biological properties of AH Plus Bioceramic (AHPB) in comparison to AH Plus (AHP) and EndoSequence BC Sealer (BC). The results showed that AHPB presented adequate properties to be considered a good sealer, however, its high solubility may negatively impact the quality of the obturation.
JOURNAL OF ENDODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Zhen Shen, Anadne Letra, Renato M. Silva
Summary: This study demonstrates that miR-10a-5p can regulate the expression of various inflammatory cytokines and growth factors, including tumor necrosis factor-alpha, interleukin-113, interleukin 3, and transforming growth factor-beta 1. Additionally, miR-10a-5p and miR-891a-5p co-regulate the expression of TGFB1 and integrate with multiple pathways in apical periodontitis.
JOURNAL OF ENDODONTICS
(2023)
Article
Developmental Biology
Yushi Redhead, Dorota Gibbins, Eva Lana-Elola, Sheona Watson-Scales, Lisa Dobson, Matthias Krause, Karen J. Liu, Elizabeth M. C. Fisher, Jeremy B. A. Green, Victor L. J. Tybulewicz
Summary: Down syndrome (DS) is a common human chromosomal abnormality that leads to various phenotypic features, including craniofacial dysmorphology. Through analysis of a DS mouse model and genetic mapping, it was found that four regions on mouse chromosome 16, which correspond to Hsa21 in humans, contain dosage-sensitive genes that contribute to DS craniofacial abnormalities, with Dyrk1a identified as one of the causative genes. The study revealed that the earliest and most severe defects in the DS mouse skulls occur in bones of neural crest origin, and that abnormal mineralization of the skull base synchondroses is present. Additionally, increased dosage of Dyrk1a was found to result in decreased proliferation of neural crest cells and a reduction in size and cellularity of the frontal bone primordia.
Article
Dentistry, Oral Surgery & Medicine
Jordano Francio, Glaucia T. das Neves, Leticia C. Souza, Everdan Carneiro, Renato M. Silva, Ariadne Letra
Summary: This study aims to evaluate the expression of genes involved in chronic pain conditions in apical periodontitis (AP) tissues. The findings show that MMP9, TIMP1, TNFA, CAMK4, and COMT are significantly upregulated in AP tissues, indicating their potential involvement in AP pathogenesis.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Anatomy & Morphology
Nian Zhang, William B. Barrell, Karen J. Liu
Summary: The Gli1 gene is suggested to mark a subpopulation of skeletal stem cells (SSCs) in craniofacial bone. The differentiation and proliferative potential of Gli1+ cells in different locations were found to be distinct.
JOURNAL OF ANATOMY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Han Na Cho, Leticia Chaves de Souza, Cleverick Johnson, John R. Klein, Timothy C. Kirkpatrick, Renato Silva, Ariadne Letra
Summary: This study compared the differential gene expression in dental pulp tissues between individuals with a history of COVID-19 and those without. The results suggest that COVID-19 may dysregulate the expression of inflammatory genes in inflamed dental pulp.
JOURNAL OF ENDODONTICS
(2023)
Article
Geriatrics & Gerontology
Nicole Dueker, Liyong Wang, Hannah Gardener, Lissette Gomez, Sonya Kaur, Ashley Beecham, Susan H. Blanton, Chuanhui Dong, Jose Gutierrez, Ying Kuen Cheung, Yeseon P. Moon, Bonnie Levin, Clinton B. Wright, Mitchell S. V. Elkind, Ralph L. Sacco, Tatjana Rundek
Summary: This study conducted a genome-wide association study on executive function in a racially and ethnically diverse cohort. They identified several SNPs in the LINC01362 gene on chromosome 1p31.1 that were significantly associated with executive function. These SNPs were found to influence the expression of genes involved in executive function in various regions of the brain.
NEUROBIOLOGY OF AGING
(2023)
Article
Anatomy & Morphology
Emily J. Lodge, William B. Barrell, Karen J. Liu, Cynthia L. Andoniadou
Summary: The primary cilium plays an important role in pituitary development through SHH signaling, and the protein FUZ is crucial for ciliogenesis. Fuz(-/-) mutants have shorter or non-functional cilia, and their pituitary gland is missing. This is due to the inadequate development and apoptosis of Rathke's pouch (RP), reduced activation of the SHH pathway, and aberrant expression of FGF8 and BMP4 signals.
JOURNAL OF ANATOMY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lauren E. Petty, Renato Silva, Leticia Chaves de Souza, Alexandre R. Vieira, Douglas M. Shaw, Jennifer E. Below, Ariadne Letra
Summary: This study is the first genome-wide association study of apical periodontitis (AP) in a large and well-characterized population. It identified novel genes/loci associated with AP and specific contributions to AP risk in men and women. Additionally, it revealed significant associations with other systemic conditions. These findings provide strong evidence for host-mediated effects on AP susceptibility.
JOURNAL OF ENDODONTICS
(2023)
Article
Cell Biology
Lisa Dobson, William B. Barrell, Zahra Seraj, Steven Lynham, Sheng-Yuan Wu, Matthias Krause, Karen J. Liu
Summary: This study demonstrates that murine neural crest cells display actin-based lamellipodia and filopodia in vivo. Serine-threonine kinase GSK3 and cytoskeletal regulator Lpd are found to be required for lamellipodia formation while preventing focal adhesion maturation. These findings improve the understanding of cytoskeletal regulation in mammalian neural crest migration and have implications for neural crest anomalies and cancer.
Article
Dentistry, Oral Surgery & Medicine
Talita Tartari, Caroline Wichnieski, Renato Menezes Silva, Ariadne Letra, Marco Antonio Hungaro Duarte, Clovis Monteiro Bramante
Summary: Different final irrigation protocols can affect the dentin surface characteristics and the adhesion of endodontic sealers. Among them, the protocols of 2.5% sodium hypochlorite (NaOCl) + 17% ethylenediaminetetraacetic acid (EDTA) and 5% NaOCl + 18% etidronate (HEDP) showed relatively high push-out bond strength after 7 days and 20 months.
JOURNAL OF APPLIED ORAL SCIENCE
(2023)
Review
Dentistry, Oral Surgery & Medicine
L. Sangalli, L. C. Souza, A. Letra, L. Shaddox, E. Ioannidou
Summary: There has been a growing interest in the scientific community regarding the influence of sex and gender differences on health and disease. This is particularly important in the field of oral diseases, where evidence suggests that sexual dimorphism plays a role in disease predisposition and progression. However, current research lacks consideration of gender and other psychosocial and external factors that may impact oral health.
JOURNAL OF DENTAL RESEARCH
(2023)
