Tissue-informed engineering strategies for modeling human pulmonary diseases

Biomimetic soft fibrous hydrogels for contractile and pharmacologically responsive smooth muscle

(2018) Yonghui Ding et al.   Acta Biomaterialia

Engineered cell and tissue models of pulmonary fibrosis

(2018) Aswin Sundarakrishnan et al.   ADVANCED DRUG DELIVERY REVIEWS

Aging and anatomical variations in lung tissue stiffness

(2018) Delphine Sicard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148

(2018) Konstantin Tsoyi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Reversible Control of Network Properties in Azobenzene-Containing Hyaluronic Acid-Based Hydrogels

(2018) Adrianne M. Rosales et al.   BIOCONJUGATE CHEMISTRY

Epithelial-mesenchymal crosstalk influences cellular behavior in a 3D alveolus-fibroblast model system

(2018) Katherine J.R. Lewis et al.   BIOMATERIALS

Photopolymerized dynamic hydrogels with tunable viscoelastic properties through thioester exchange

(2018) Tobin E. Brown et al.   BIOMATERIALS

Extracellular matrix as a driver of progressive fibrosis

(2018) Jeremy Herrera et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanosensing and fibrosis

(2018) Daniel J. Tschumperlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative proteomic characterization of the lung extracellular matrix in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

(2018) Emma Åhrman et al.   Journal of Proteomics

Extracellular matrix in lung development, homeostasis and disease

(2018) Yong Zhou et al.   MATRIX BIOLOGY

Matrix remodeling in chronic lung diseases

(2018) Bon-Hee Gu et al.   MATRIX BIOLOGY

Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery

(2018) Barry A. Badeau et al.   Nature Chemistry

Photoresponsive biomaterials for targeted drug delivery and 4D cell culture

(2018) Emily R. Ruskowitz et al.   Nature Reviews Materials

Production and transplantation of bioengineered lung into a large-animal model

(2018) Joan E. Nichols et al.   Science Translational Medicine

Probing Fibroblast Activation in Response to Extracellular Cues with Whole Protein- or Peptide-Functionalized Step-Growth Hydrogels

(2018) Megan E. Smithmyer et al.   ACS Biomaterials-Science & Engineering

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

(2017) Gerald Burgstaller et al.   EUROPEAN RESPIRATORY JOURNAL

Functional characterization of a novel 3D model of the epithelial-mesenchymal trophic unit

(2017) Fabio Bucchieri et al.   EXPERIMENTAL LUNG RESEARCH

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics

(2017) Alexandra Naba et al.   JOURNAL OF PROTEOME RESEARCH

Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution

(2017) Xiaoqiu Liu et al.   LABORATORY INVESTIGATION

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

Matrix biomechanics and dynamics in pulmonary fibrosis

(2017) Andrew J. Haak et al.   MATRIX BIOLOGY

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival

(2017) Vasilena Gocheva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Throughput Screening of Vascular Endothelium-Destructive or Protective Microenvironments: Cooperative Actions of Extracellular Matrix Composition, Stiffness, and Structure

(2017) Yonghui Ding et al.   Advanced Healthcare Materials

Proceedings: Regenerative Medicine for Lung Diseases: A CIRM Workshop Report

(2017) Lisa C. Kadyk et al.   Stem Cells Translational Medicine

Idiopathic pulmonary fibrosis

(2017) Fernando J. Martinez et al.   Nature Reviews Disease Primers

Stepping into the omics era: Opportunities and challenges for biomaterials science and engineering

(2016) Nathalie Groen et al.   Acta Biomaterialia

Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices

(2016) Elizabeth A. Calle et al.   Acta Biomaterialia

High-throughput screening approaches and combinatorial development of biomaterials using microfluidics

(2016) David Barata et al.   Acta Biomaterialia

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

FGF9 and FGF18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts in vitro

(2016) Audrey Joannes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

HIPPO–Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension

(2016) Tatiana V. Kudryashova et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix Remodeling in Pulmonary Fibrosis and Emphysema

(2016) Tejaswini Kulkarni et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Evaluation of a Gelatin-Modified Poly(ε-Caprolactone) Film as a Scaffold for Lung Disease

(2016) Aleksandra Kosmala et al.   ANALYTICAL LETTERS

Current advances and future perspectives in extrusion-based bioprinting

(2016) Ibrahim T. Ozbolat et al.   BIOMATERIALS

Mechanosensing via cell-matrix adhesions in 3D microenvironments

(2016) Andrew D. Doyle et al.   EXPERIMENTAL CELL RESEARCH

The extracellular matrix - the under-recognized element in lung disease?

(2016) Janette K Burgess et al.   JOURNAL OF PATHOLOGY

Lung donor shortage – how to overcome it?

(2016) Bartłomiej Zych et al.   Kardiochirurgia i Torakochirurgia Polska

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

A review on electrospun polymer nanostructures as advanced bioactive platforms

(2016) Sergio Torres-Giner et al.   POLYMER ENGINEERING AND SCIENCE

Three-dimensional bioprinting of thick vascularized tissues

(2016) David B. Kolesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels

(2016) Keely A. Heintz et al.   Advanced Healthcare Materials

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling

(2016) Dan C. Wilkinson et al.   Stem Cells Translational Medicine

In vitro modeling of COPD inflammation and limitation of p38 inhibitor — SB203580

(2016) Aihong Meng et al.   International Journal of Chronic Obstructive Pulmonary Disease

Pulmonary hypertension: still a rare disease?

(2016) The Lancet Respiratory Medicine   Lancet Respiratory Medicine

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

(2016) Kambez H. Benam et al.   Cell Systems

Engineered small diameter vascular grafts by combining cell sheet engineering and electrospinning technology

(2015) Hyunhee Ahn et al.   Acta Biomaterialia

The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes

(2015) Steven C. Pugliese et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Three-dimensional, soft neotissue arrays as high throughput platforms for the interrogation of engineered tissue environments

(2015) Michael Floren et al.   BIOMATERIALS

Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures

(2015) Franziska E. Uhl et al.   EUROPEAN RESPIRATORY JOURNAL

Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction

(2015) Vincent F. Fiore et al.   JOURNAL OF CELL BIOLOGY

A review of key challenges of electrospun scaffolds for tissue-engineering applications

(2015) Sajedeh Khorshidi et al.   Journal of Tissue Engineering and Regenerative Medicine

Time- and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair

(2015) H. B. Schiller et al.   Molecular Systems Biology

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Automated Decellularization of Intact, Human-Sized Lungs for Tissue Engineering

(2015) Andrew P. Price et al.   TISSUE ENGINEERING PART C-METHODS

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

Methylation-mediated BMPER expression in fibroblast activation in vitro and lung fibrosis in mice in vivo

(2015) Caijuan Huan et al.   Scientific Reports

Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit

(2015) Thomas Bertero et al.   Cell Reports

In vitro model alveoli from photodegradable microsphere templates

(2015) Katherine J. R. Lewis et al.   Biomaterials Science

Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-β Induced Myofibroblast Differentiation via Prostaglandin E2

(2015) Amali P. Epa et al.   PLoS One

Engineering an in vitro air-blood barrier by 3D bioprinting

(2015) Lenke Horváth et al.   Scientific Reports

3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

(2014) David B. Kolesky et al.   ADVANCED MATERIALS

The Site and Nature of Airway Obstruction after Lung Transplantation

(2014) Stijn E. Verleden et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reviews and prospectives of signaling pathway analysis in idiopathic pulmonary fibrosis

(2014) Zheng Yan et al.   AUTOIMMUNITY REVIEWS

Extracellular matrix: A dynamic microenvironment for stem cell niche

(2014) Francesca Gattazzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Comparative decellularization and recellularization of normal versus emphysematous human lungs

(2014) Darcy E. Wagner et al.   BIOMATERIALS

Generation of Multi-scale Vascular Network System Within 3D Hydrogel Using 3D Bio-printing Technology

(2014) Vivian K. Lee et al.   Cellular and Molecular Bioengineering

Design of growth factor sequestering biomaterials

(2014) David G. Belair et al.   CHEMICAL COMMUNICATIONS

Covalently tethered TGF-β1 with encapsulated chondrocytes in a PEG hydrogel system enhances extracellular matrix production

(2014) Balaji V. Sridhar et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Extracellular matrix elasticity and topography: Material-based cues that affect cell function via conserved mechanisms

(2014) Isaac A. Janson et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

(2014) Matthew W. Parker et al.   JOURNAL OF CLINICAL INVESTIGATION

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clickable, Photodegradable Hydrogels to Dynamically Modulate Valvular Interstitial Cell Phenotype

(2014) Chelsea M. Kirschner et al.   Advanced Healthcare Materials

The epithelium in idiopathic pulmonary fibrosis: breaking the barrier

(2014) Ana Camelo et al.   Frontiers in Pharmacology

Hydrogels in healthcare: From static to dynamic material microenvironments

(2013) Chelsea M. Kirschner et al.   ACTA MATERIALIA

Future Directions in Idiopathic Pulmonary Fibrosis Research. An NHLBI Workshop Report

(2013) Timothy S. Blackwell et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Animal Models of Fibrotic Lung Disease

(2013) Bethany B. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathogenesis of Idiopathic Pulmonary Fibrosis

(2013) Paul J. Wolters et al.   Annual Review of Pathology-Mechanisms of Disease

A Diels–Alder modulated approach to control and sustain the release of dexamethasone and induce osteogenic differentiation of human mesenchymal stem cells

(2013) Kenneth C. Koehler et al.   BIOMATERIALS

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

(2013) T. R. Cox et al.   CANCER RESEARCH

Defining the extracellular matrix using proteomics

(2013) Adam Byron et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness

(2012) Aleksandar Marinković et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Matrices of Physiologic Stiffness Potently Inactivate Idiopathic Pulmonary Fibrosis Fibroblasts

(2012) Aleksandar Marinković et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

Evaluation of hydrogels for bio-printing applications

(2012) Sean V. Murphy et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions

(2012) Ashley C Brown et al.   JOURNAL OF PATHOLOGY

Engineering ECM signals into biomaterials

(2012) Ryan J. Wade et al.   Materials Today

Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure

(2012) Xiyi Chen et al.   Nature Protocols

What Is the Greatest Regulatory Challenge in the Translation of Biomaterials to the Clinic?

(2012) G. D. Prestwich et al.   Science Translational Medicine

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

In Situ Control of Cell Substrate Microtopographies Using Photolabile Hydrogels

(2012) Chelsea M. Kirschner et al.   Small

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Covalently tethered transforming growth factor beta in PEG hydrogels promotes chondrogenic differentiation of encapsulated human mesenchymal stem cells

(2012) Joshua D. McCall et al.   Drug Delivery and Translational Research

An in situ forming collagen–PEG hydrogel for tissue regeneration

(2011) Timothy D. Sargeant et al.   Acta Biomaterialia

What do we know about mechanical strain in lung alveoli?

(2011) Esra Roan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Transglutaminase 2 and Its Role in Pulmonary Fibrosis

(2011) Keith C. Olsen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanical derivation of functional myotubes from adipose-derived stem cells

(2011) Yu Suk Choi et al.   BIOMATERIALS

Reference Values for Normal Pulmonary Artery Dimensions by Noncontrast Cardiac Computed Tomography

(2011) Quynh A. Truong et al.   Circulation-Cardiovascular Imaging

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions

(2011) Cole A. DeForest et al.   Nature Chemistry

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

(2011) Rebecca J. McMurray et al.   NATURE MATERIALS

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate

(2011) Justin R. Tse et al.   PLoS One

Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy

(2011) Fei Liu et al.   Jove-Journal of Visualized Experiments

Microtopographical regulation of adult bone marrow progenitor cells chondrogenic and osteogenic gene and protein expressions

(2010) Y. Yang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Extracellular matrix remodeling of lung alveolar walls in three dimensional space identified using second harmonic generation and multiphoton excitation fluorescence

(2010) Thomas Abraham et al.   JOURNAL OF STRUCTURAL BIOLOGY

Synthesis of photodegradable hydrogels as dynamically tunable cell culture platforms

(2010) April M Kloxin et al.   Nature Protocols

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Microtopographical Cues in 3D Attenuate Fibrotic Phenotype and Extracellular Matrix Deposition: Implications for Tissue Regeneration

(2010) Perla Ayala et al.   TISSUE ENGINEERING PART A

How Do Cells Make Decisions: Engineering Micro- and Nanoenvironments for Cell Migration

(2010) Siti Hawa Ngalim et al.   Journal of Oncology

Post microtextures accelerate cell proliferation and osteogenesis

(2009) Eun Jung Kim et al.   Acta Biomaterialia

A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization

(2009) Benjamin D. Fairbanks et al.   ADVANCED MATERIALS

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Using Azobenzene-Embedded Self-Assembled Monolayers To Photochemically Control Cell Adhesion Reversibly

(2009) Dingbin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Surface Topography Induces Fibroblast Adhesion on Intrinsically Nonadhesive Poly(ethylene glycol) Substrates

(2009) Vera A. Schulte et al.   BIOMACROMOLECULES

Poly(ethylene glycol) hydrogels formed by thiol-ene photopolymerization for enzyme-responsive protein delivery

(2009) Alex A. Aimetti et al.   BIOMATERIALS

In situ elasticity modulation with dynamic substrates to direct cell phenotype

(2009) April M. Kloxin et al.   BIOMATERIALS

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

Photocontrolled Cell Adhesion on a Surface Functionalized with a Caged Arginine-Glycine-Aspartate Peptide

(2008) Yuki Ohmuro-Matsuyama et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phototriggering of Cell Adhesion by Caged Cyclic RGD Peptides

(2008) Svea Petersen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The enhancement of chondrogenic differentiation of human mesenchymal stem cells by enzymatically regulated RGD functionalities

(2008) Chelsea N. Salinas et al.   BIOMATERIALS