Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

3-Hydroxy-3-Methylglutaryl-COA Reductase Inhibitors and Phosphodiesterase Type V Inhibitors Attenuate Right Ventricular Pressure and Remodeling in a Rat Model of Pulmonary Hypertension

(2016) Mitsutoshi Satoh et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Stiffening of the Extrapulmonary Arteries From Rats in Chronic Hypoxic Pulmonary Hypertension

(2012) E. S. Drexler et al.   JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY

Neprilysin Null Mice Develop Exaggerated Pulmonary Vascular Remodeling in Response to Chronic Hypoxia

(2009) Edward C. Dempsey et al.   AMERICAN JOURNAL OF PATHOLOGY

Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment

(2009) Danielle L. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Update in Pulmonary Hypertension 2008

(2009) Marc Humbert   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Vasoactive Intestinal Peptide Gene Is a Key Modulator of Pulmonary Vascular Remodeling and Inflammation

(2009) Sami I. Said   Annals of the New York Academy of Sciences

Propylthiouracil Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

(2009) Cheuk-Kwan Sun et al.   CIRCULATION JOURNAL

Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3–microRNA Cluster 17/92 Pathway

(2009) Matthias Brock et al.   CIRCULATION RESEARCH

CPU0213, A NON-SELECTIVE ETA/ETBRECEPTOR ANTAGONIST, IMPROVES PULMONARY ARTERIOLAR REMODELING OF MONOCROTALINE-INDUCED PULMONARY HYPERTENSION IN RATS

(2009) Bing Cui et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Endothelial progenitor cells may inhibit apoptosis of pulmonary microvascular endothelial cells: new insights into cell therapy for pulmonary arterial hypertension

(2009) Liang Xia et al.   CYTOTHERAPY

A meta-analysis of randomized controlled trials in pulmonary arterial hypertension

(2009) N. Galie et al.   EUROPEAN HEART JOURNAL

Pulmonary arterial hypertension in limited cutaneous systemic sclerosis: a distinctive vasculopathy

(2009) M. J. Overbeek et al.   EUROPEAN RESPIRATORY JOURNAL

Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats

(2009) Anna Csiszar et al.   HYPERTENSION

Evaluation of Olmesartan Medoxomil in the Rat Monocrotaline Model of Pulmonary Hypertension

(2009) Tomohiro Kato et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Effects of Roflumilast, a Phosphodiesterase-4 Inhibitor, on Hypoxia- and Monocrotaline-Induced Pulmonary Hypertension in Rats

(2009) M. Izikki et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension

(2009) Vallerie V. McLaughlin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Diagnosis and Assessment of Pulmonary Arterial Hypertension

(2009) David B. Badesch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Updated Clinical Classification of Pulmonary Hypertension

(2009) Gérald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pathology of Pulmonary Arterial Hypertension

(2009) Rubin Tuder   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Circulating Angiogenic Precursors in Idiopathic Pulmonary Arterial Hypertension

(2008) Kewal Asosingh et al.   AMERICAN JOURNAL OF PATHOLOGY

Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves

(2008) Steven R. Lammers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions

(2008) James West et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension

(2008) S. M. Majka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone

(2008) Noriyuki Homma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling

(2008) Eva Nozik-Grayck et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Update in Pulmonary Arterial Hypertension 2007

(2008) Marc Humbert   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia

(2008) Kristine D. Estrada et al.   Biomechanics and Modeling in Mechanobiology

Molecular Mechanisms of Pulmonary Arterial Hypertension

(2008) Rachel J. Davies et al.   CHEST

Genetic Ablation of the Bmpr2 Gene in Pulmonary Endothelium Is Sufficient to Predispose to Pulmonary Arterial Hypertension

(2008) Kwon-Ho Hong et al.   CIRCULATION

Uncertainties in the Diagnosis and Treatment of Pulmonary Arterial Hypertension

(2008) Hossein A. Ghofrani et al.   CIRCULATION

Combined Tyrosine and Serine/Threonine Kinase Inhibition by Sorafenib Prevents Progression of Experimental Pulmonary Hypertension and Myocardial Remodeling

(2008) Martina Klein et al.   CIRCULATION

Emerging Concepts and Translational Priorities in Pulmonary Arterial Hypertension

(2008) Evangelos D. Michelakis et al.   CIRCULATION

Interleukin-6 Overexpression Induces Pulmonary Hypertension

(2008) M. Kathryn Steiner et al.   CIRCULATION RESEARCH

Management of Pulmonary Arterial Hypertension Associated with Congenital Systemic-to-Pulmonary Shunts and Eisenmenger???s Syndrome

(2008) Nazzareno Galie et al.   DRUGS

MURINE PULMONARY RESPONSE TO CHRONIC HYPOXIA IS STRAIN SPECIFIC

(2008) Yuji Tada et al.   EXPERIMENTAL LUNG RESEARCH

Right heart function and haemodynamics in pulmonary hypertension

(2008) A. R. Hemnes et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2- -N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form,  acetic Acid (MRE-269), on Rat Pulmonary Artery

(2008) K. Kuwano et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents

(2008) Rosemary C Jones et al.   Nature Protocols

Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension

(2008) Liliana Moreno-Vinasco et al.   PHYSIOLOGICAL GENOMICS

2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling

(2008) Stevan P. Tofovic et al.   VASCULAR PHARMACOLOGY

Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension

(2007) Kendall S. Hunter et al.   AMERICAN HEART JOURNAL

Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature

(2007) David B. Frank et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Single Injection of a Sustained-release Prostacyclin Analog Improves Pulmonary Hypertension in Rats

(2007) Hiroaki Obata et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pathogenic mechanisms of pulmonary arterial hypertension

(2007) Stephen Y. Chan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY