The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes

Spontaneous Development of Autoimmune Uveitis Is CCR2 Dependent

(2014) YuTing Feeling Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension

(2014) Masayuki Koyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

High proliferative potential endothelial colony-forming cells contribute to hypoxia-induced pulmonary artery vasa vasorum neovascularization

(2014) Hala Nijmeh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia-induced mitogenic factor (FIZZ1/RELMα) induces endothelial cell apoptosis and subsequent interleukin-4-dependent pulmonary hypertension

(2014) Kazuyo Yamaji-Kegan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Arginase II is a target of miR-17-5p and regulates miR-17-5p expression in human pulmonary artery smooth muscle cells

(2014) Youpeng Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

miR-210 promotes IPF fibroblast proliferation in response to hypoxia

(2014) Vidya Bodempudi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Osteopontin – A multi-modal marker and mediator in atherosclerotic vascular disease

(2014) Talya Wolak   ATHEROSCLEROSIS

Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance

(2014) Zhongwei Cao et al.   CANCER CELL

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Aberrant Chloride Intracellular Channel 4 Expression Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2014) Beata Wojciak-Stothard et al.   CIRCULATION

CCR5 as a Treatment Target in Pulmonary Arterial Hypertension

(2014) Valérie Amsellem et al.   CIRCULATION

Pulmonary Arterial Hypertension

(2014) Yen-Chun Lai et al.   CIRCULATION RESEARCH

Implication of the Tpl2 Kinase in Inflammatory Changes and Insulin Resistance Induced by the Interaction Between Adipocytes and Macrophages

(2014) Franck Ceppo et al.   ENDOCRINOLOGY

Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation

(2014) Ceri A. Fielding et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension

(2014) Karim C. El Kasmi et al.   JOURNAL OF IMMUNOLOGY

Modulation of TNF-Induced Macrophage Polarization by Synovial Fibroblasts

(2014) Laura T. Donlin et al.   JOURNAL OF IMMUNOLOGY

Reprogramming human endothelial cells to haematopoietic cells requires vascular induction

(2014) Vladislav M. Sandler et al.   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Ion channels and transporters as therapeutic targets in the pulmonary circulation

(2014) Andrea Olschewski et al.   PHARMACOLOGY & THERAPEUTICS

Chronic Hypoxia Promotes Pulmonary Artery Endothelial Cell Proliferation through H2O2-Induced 5-Lipoxygenase

(2014) Kristi M. Porter et al.   PLoS One

Stiffening-Induced High Pulsatility Flow Activates Endothelial Inflammation via a TLR2/NF-κB Pathway

(2014) Yan Tan et al.   PLoS One

Recapitulation of Developing Artery Muscularization in Pulmonary Hypertension

(2014) Abdul Q. Sheikh et al.   Cell Reports

Progenitor Cells in Pulmonary Vascular Remodeling

(2014) Michael E. Yeager et al.   Pulmonary Circulation

Effects of chronic exposure to cigarette smoke on canonical transient receptor potential expression in rat pulmonary arterial smooth muscle

(2013) Jian Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension

(2013) Carlos H. Nitta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs

(2013) Daniela Parrau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1

(2013) Sarah Pisarcik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2

(2013) Jun Wan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NFAT is required for spontaneous pulmonary hypertension in superoxide dismutase 1 knockout mice

(2013) Juan Manuel Ramiro-Diaz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The role of hypoxia in pulmonary vascular diseases: a perspective

(2013) Norbert F. Voelkel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α

(2013) Molly K. Ball et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypoxia-Induced Inflammation in the Lung

(2013) Stephen Fröhlich et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Differential Regulation of Pulmonary Vascular Cell Growth by Hypoxia-Inducible Transcription Factor–1α and Hypoxia-Inducible Transcription Factor–2α

(2013) Aftab Ahmad et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

15-Lipoxygenase Promotes Chronic Hypoxia–Induced Pulmonary Artery Inflammation via Positive Interaction With Nuclear Factor-κB

(2013) Jing Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of macrophage-derived hypoxia-inducible factor (HIF)-1α as a mediator of vascular remodelling

(2013) Taisuke Nakayama et al.   CARDIOVASCULAR RESEARCH

Biomarkers in Pulmonary Hypertension

(2013) Vasile Foris et al.   CHEST

Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

(2013) Maulik D. Majmudar et al.   CIRCULATION

Mammalian Target of Rapamycin Complex 2 (mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension

(2013) Dmitry A. Goncharov et al.   CIRCULATION

MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts

(2013) Daren Wang et al.   CIRCULATION RESEARCH

Pathology of Pulmonary Hypertension

(2013) Rubin M. Tuder et al.   CLINICS IN CHEST MEDICINE

Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis

(2013) Bo S. Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chemistry meets biology in colitis-associated carcinogenesis

(2013) A. Mangerich et al.   FREE RADICAL RESEARCH

Cellular Responses to Hypoxia in the Pulmonary Circulation

(2013) David J. Welsh et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Transcriptional regulation of increased CCL2 expression in pulmonary fibrosis involves nuclear factor-κB and activator protein-1

(2013) Xiaoling Deng et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Implicating Exudate Macrophages and Ly-6Chigh Monocytes in CCR2-Dependent Lung Fibrosis following Gene-Targeted Alveolar Injury

(2013) J. J. Osterholzer et al.   JOURNAL OF IMMUNOLOGY

Genetics and Genomics of Pulmonary Arterial Hypertension

(2013) Florent Soubrier et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pulmonary Hypertension in Chronic Lung Diseases

(2013) Werner Seeger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension

(2013) Rubin M. Tuder et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Updated Clinical Classification of Pulmonary Hypertension

(2013) Gerald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An investigation into beef calf mortality on five high-altitude ranches that selected sires with low pulmonary arterial pressures for over 20 years

(2013) Joseph M. Neary et al.   JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION

MicroRNA-206 is involved in hypoxia-induced pulmonary hypertension through targeting of the HIF-1α/Fhl-1 pathway

(2013) Junqiu Yue et al.   LABORATORY INVESTIGATION

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

A Novel Channelopathy in Pulmonary Arterial Hypertension

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Channelopathy in Pulmonary Arterial Hypertension

(2013) Lijiang Ma et al.   NEW ENGLAND JOURNAL OF MEDICINE

STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells

(2013) M R Pawlus et al.   ONCOGENE

Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression

(2013) G Comito et al.   ONCOGENE

Nuclear Factor κ-B Is Activated in the Pulmonary Vessels of Patients with End-Stage Idiopathic Pulmonary Arterial Hypertension

(2013) Laura C. Price et al.   PLoS One

Xanthine Oxidase Mediates Hypoxia-Inducible Factor-2α Degradation by Intermittent Hypoxia

(2013) Jayasri Nanduri et al.   PLoS One

Pathology and Pathobiology of Pulmonary Hypertension

(2013) Christophe Guignabert et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Selective Inactivation of PTEN in Smooth Muscle Cells Synergizes With Hypoxia to Induce Severe Pulmonary Hypertension

(2013) Henrick Horita et al.   Journal of the American Heart Association

Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension

(2012) Abigail S. Forrest et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone

(2012) G. Frazziano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation

(2012) Qiwei Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1

(2012) Kyle Leggett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats

(2012) Diana Dahan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia-induced endothelial CX3CL1 triggers lung smooth muscle cell phenotypic switching and proliferative expansion

(2012) Jianliang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects

(2012) Jose Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling

(2012) Shanzhong Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism

(2012) Paul W. Buehler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension

(2012) Adil Anwar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia

(2012) Deming Gou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Wnt5a inhibits hypoxia-induced pulmonary arterial smooth muscle cell proliferation by downregulation of β-catenin

(2012) Xiao-Min Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Adventitia: Essential Regulator of Vascular Wall Structure and Function

(2012) Kurt R. Stenmark et al.   Annual Review of Physiology

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling

(2012) Evgeniy Panzhinskiy et al.   CARDIOVASCULAR RESEARCH

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Histone Deacetylation Inhibition in Pulmonary Hypertension

(2012) Lan Zhao et al.   CIRCULATION

Selective Class I Histone Deacetylase Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Antiproliferative Mechanism

(2012) Maria A. Cavasin et al.   CIRCULATION RESEARCH

A Role for miR-145 in Pulmonary Arterial Hypertension

(2012) Paola Caruso et al.   CIRCULATION RESEARCH

Enhanced Ca 2+ -Sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension

(2012) Aya Yamamura et al.   CIRCULATION RESEARCH

Bone Morphogenetic Protein Signaling in Vascular Disease

(2012) Dahai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis

(2012) Minako Arai et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Pulmonary arterial lesions in explanted lungs after transplantation correlate with severity of pulmonary hypertension in chronic obstructive pulmonary disease

(2012) Jørn Carlsen et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease

(2012) Jens M. Poth et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Chronic hypoxia-induced upregulation of Ca2+-activated Cl−channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity

(2012) Hui Sun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Right ventricular hypertrophy with heart failure in Holstein heifers at elevation of 1,600 meters

(2012) Christopher R. Malherbe et al.   JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION

Unknown

(2012) Mohamed Ahmed et al.   MOLECULAR MEDICINE

Antagonism of CXCR7 attenuates chronic hypoxia–induced pulmonary hypertension

(2012) Ecaterina Sartina et al.   PEDIATRIC RESEARCH

Hypoxic Pulmonary Vasoconstriction

(2012) J. T. Sylvester et al.   PHYSIOLOGICAL REVIEWS

Macrophage-Associated Mesenchymal Stem Cells Assume an Activated, Migratory, Pro-Inflammatory Phenotype with Increased IL-6 and CXCL10 Secretion

(2012) Kevin Anton et al.   PLoS One

Digoxin inhibits development of hypoxic pulmonary hypertension in mice

(2012) E. M. Abud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nifedipine inhibits hypoxia induced transvascular leakage through down regulation of NFkB

(2012) Sarada S.K.S. et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Targeting the Adventitial Microenvironment in Pulmonary Hypertension: A Potential Approach to Therapy that Considers Epigenetic Change

(2012) Kurt R. Stenmark et al.   Pulmonary Circulation

Distinct Responses to Hypoxia in Subpopulations of Distal Pulmonary Artery Cells Contribute to Pulmonary Vascular Remodeling in Emphysema

(2012) L. S. Howard et al.   Pulmonary Circulation

Mast Cell Number, Phenotype, and Function in Human Pulmonary Arterial Hypertension

(2012) Samar Farha et al.   Pulmonary Circulation

Activation of the Unfolded Protein Response is Associated with Pulmonary Hypertension

(2012) Michael E. Yeager et al.   Pulmonary Circulation

High Pulsatility Flow Induces Acute Endothelial Inflammation Through Overpolarizing Cells to Activate NF-κB

(2012) Min Li et al.   Cardiovascular Engineering and Technology

Chronic hypoxia upregulates pulmonary arterial ASIC1: a novel mechanism of enhanced store-operated Ca2+ entry and receptor-dependent vasoconstriction

(2011) Nikki L. Jernigan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Enhanced store-operated Ca2+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats

(2011) Xiao-Ru Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling

(2011) Kaizheng Gong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension

(2011) Xiao-Ru Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Targeting Energetic Metabolism

(2011) Rubin M. Tuder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of MicroRNA-17 Improves Lung and Heart Function in Experimental Pulmonary Hypertension

(2011) Soni S. Pullamsetti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Silencing of Sodium–Hydrogen Exchanger 1 Attenuates the Proliferation, Hypertrophy, and Migration of Pulmonary Artery Smooth Muscle Cells via E2F1

(2011) Lunyin Yu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation Is Controlled by Forkhead Box M1

(2011) Aarti Raghavan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endothelin-1, the Unfolded Protein Response, and Persistent Inflammation

(2011) Michael E. Yeager et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pro-angiogenic hematopoietic progenitor cells and endothelial colony-forming cells in pathological angiogenesis of bronchial and pulmonary circulation

(2011) Heng T. Duong et al.   ANGIOGENESIS

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities

(2011) S. Farha et al.   BLOOD

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Mast Cell Inhibition Improves Pulmonary Vascular Remodeling in Pulmonary Hypertension

(2011) Beatrijs Bartelds et al.   CHEST

Early Macrophage Recruitment and Alternative Activation Are Critical for the Later Development of Hypoxia-Induced Pulmonary Hypertension

(2011) Eleni Vergadi et al.   CIRCULATION

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

(2011) Federico Formenti et al.   FASEB JOURNAL

Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling

(2011) Imad Al Ghouleh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exacerbated Pulmonary Arterial Hypertension and Right Ventricular Hypertrophy in Animals With Loss of Function of Extracellular Superoxide Dismutase

(2011) Dachun Xu et al.   HYPERTENSION

Epigenetics: New Questions on the Response to Hypoxia

(2011) Joel I. Perez-Perri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role for miR-204 in human pulmonary arterial hypertension

(2011) Audrey Courboulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emergence of Fibroblasts with a Proinflammatory Epigenetically Altered Phenotype in Severe Hypoxic Pulmonary Hypertension

(2011) M. Li et al.   JOURNAL OF IMMUNOLOGY

Hypoxia Does neither Stimulate Pulmonary Artery Endothelial Cell Proliferation in Mice and Rats with Pulmonary Hypertension and Vascular Remodeling nor in Human Pulmonary Artery Endothelial Cells

(2011) Lunyin Yu et al.   JOURNAL OF VASCULAR RESEARCH

miR-210: The Master Hypoxamir

(2011) YUK C. CHAN et al.   MICROCIRCULATION

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Alveolar macrophages initiate the systemic microvascular inflammatory response to alveolar hypoxia

(2011) Jie Chao et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration

(2010) Joy Sarkar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Smooth Muscle Proliferation and Role of the Prostacyclin (IP) Receptor in Idiopathic Pulmonary Arterial Hypertension

(2010) Emilia Falcetti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lung Extracellular Superoxide Dismutase Overexpression Lessens Bleomycin-Induced Pulmonary Hypertension and Vascular Remodeling

(2010) Zachary Van Rheen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Perivascular Responses after Angioplasty Which May Contribute to Postangioplasty Restenosis

(2010) JOSIAH N. WILCOX et al.   Annals of the New York Academy of Sciences

Adventitia-Derived Hydrogen Peroxide Impairs Relaxation of the Rat Carotid Artery via Smooth Muscle Cell p38 Mitogen-Activated Protein Kinase

(2010) Thomas Cascino et al.   ANTIOXIDANTS & REDOX SIGNALING

Dynamic Changes in Lung MicroRNA Profiles During the Development of Pulmonary Hypertension due to Chronic Hypoxia and Monocrotaline

(2010) Paola Caruso et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

(2010) Kohtaro Abe et al.   CIRCULATION

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

(2010) Stephen L. Archer et al.   CIRCULATION

Epigenetics: The epicenter of the hypoxic response

(2010) Jenny A. Watson et al.   Epigenetics

Targeting of c-kit+ haematopoietic progenitor cells prevents hypoxic pulmonary hypertension

(2010) N. Gambaryan et al.   EUROPEAN RESPIRATORY JOURNAL

Mast cells promote lung vascular remodelling in pulmonary hypertension

(2010) J. Hoffmann et al.   EUROPEAN RESPIRATORY JOURNAL

Xanthine Oxidoreductase Promotes the Inflammatory State of Mononuclear Phagocytes through Effects on Chemokine Expression, Peroxisome Proliferator-activated Receptor-γ Sumoylation, and HIF-1α

(2010) Sophie Gibbings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase Inhibitors: The Epigenetic Therapeutics That Repress Hypoxia-Inducible Factors

(2010) Shuyang Chen et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Hypoxia-Induced Mitogenic Factor (HIMF/FIZZ1/RELM ) Increases Lung Inflammation and Activates Pulmonary Microvascular Endothelial Cells via an IL-4-Dependent Mechanism

(2010) K. Yamaji-Kegan et al.   JOURNAL OF IMMUNOLOGY

Inflammation, HIF-1, and the Epigenetics That Follows

(2010) Claudio Brigati et al.   MEDIATORS OF INFLAMMATION

Hypoxia-induced changes in pulmonary and systemic vascular resistance: Where is the O2 sensor?

(2010) Gregory B. Waypa et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Interactions between calcium and reactive oxygen species in pulmonary arterial smooth muscle responses to hypoxia

(2010) Larissa A. Shimoda et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase

(2009) Bernadette Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment

(2009) Danielle L. Burke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall

(2009) Maria G. Frid et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Resistin-Like Molecule-β in Scleroderma-Associated Pulmonary Hypertension

(2009) Daniel J. Angelini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

High Pulsatility Flow Induces Adhesion Molecule and Cytokine mRNA Expression in Distal Pulmonary Artery Endothelial Cells

(2009) Min Li et al.   ANNALS OF BIOMEDICAL ENGINEERING

Pulmonary Arterial Hypertension

(2009) David B. Badesch et al.   CHEST

Inhibition of the SDF-1/CXCR4 Axis Attenuates Neonatal Hypoxia-Induced Pulmonary Hypertension

(2009) Karen C. Young et al.   CIRCULATION RESEARCH

NOX and inflammation in the vascular adventitia

(2009) Gábor Csányi et al.   FREE RADICAL BIOLOGY AND MEDICINE

ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension

(2009) Vallerie V. McLaughlin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effects of Pathological Flow on Pulmonary Artery Endothelial Production of Vasoactive Mediators and Growth Factors

(2009) Min Li et al.   JOURNAL OF VASCULAR RESEARCH

Xanthine oxidoreductase in respiratory and cardiovascular disorders

(2008) Adel Boueiz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pyrrolidine dithiocarbamate restores endothelial cell membrane integrity and attenuates monocrotaline-induced pulmonary artery hypertension

(2008) Jing Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia Selectively Activates the CREB Family of Transcription Factors in theIn VivoLung

(2008) Martin O. Leonard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Compartmentalization of Redox Signaling Through NADPH Oxidase–Derived ROS

(2008) Masuko Ushio-Fukai   ANTIOXIDANTS & REDOX SIGNALING

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2  mutation

(2008) D. P. Gale et al.   BLOOD

Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKC  in the pulmonary artery adventitia

(2008) M. Das et al.   CARDIOVASCULAR RESEARCH

Nitric Oxide–Mediated Zinc Release Contributes to Hypoxic Regulation of Pulmonary Vascular Tone

(2008) Paula J. Bernal et al.   CIRCULATION RESEARCH

Interleukin-6 Overexpression Induces Pulmonary Hypertension

(2008) M. Kathryn Steiner et al.   CIRCULATION RESEARCH

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Prevention of Mast Cell Degranulation by Disodium Cromoglycate Attenuates the Development of Hypoxic Pulmonary Hypertension in Rats Exposed to Chronic Hypoxia

(2008) Alena Baňasová et al.   RESPIRATION

Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats

(2007) Robert P. Jankov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Intravital microscopy of the murine pulmonary microcirculation

(2007) Arata Tabuchi et al.   JOURNAL OF APPLIED PHYSIOLOGY