Article
Pharmacology & Pharmacy
Feng Feng, Xueyan Feng, Di Zhang, Qilong Li, Li Yao
Summary: The study reveals that vascular pericytes are responsive to matrix stiffness, with mechanical stimuli inducing their transition into fibroblasts. Gels mimicking tumor tissue stiffness promote cell migration and invasiveness, while gels mimicking healthy tissue stiffness retain the characteristics of pericytes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Rukshika S. Hewawasam, Rachel Blomberg, Predrag Serbedzija, Chelsea M. Magin
Summary: Tissue fibrosis is a serious health condition, and there is a need for model systems that can better mimic the changes in the fibrotic extracellular microenvironment. In this study, human decellularized extracellular matrix (dECM) was chemically modified and incorporated into a tunable hybrid-hydrogel system to recapitulate the mechanical properties of healthy tissue types and mimic a fibrotic microenvironment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Fong-Sian Lin, Jian- Lee, Alvin Kai-Xing Lee, Chia-Che Ho, Yen-Ting Liu, Ming-You Shie
Summary: Infusing silicon ions into gelatin methacrylate hydrogels can enhance wound healing and skin regeneration by promoting cellular adhesion, proliferation, and secretion of important extracellular matrix proteins. This innovative approach shows promise for future clinical applications in skin regeneration.
Article
Biochemistry & Molecular Biology
Aya Tentaku, Shusaku Kurisu, Kurumi Sejima, Toshiki Nagao, Akira Takahashi, Shigenobu Yonemura
Summary: The basement membrane (BM) is a crucial extracellular matrix that maintains tissue integrity and function. The mechanisms of how stroma-derived macromolecules, such as collagen IV, are transported and assembled during BM formation remained unclear. This study established an in vitro co-culture model and found that fibroblasts proximal to epithelial cells exclusively contribute to collagen IV assembly.
Article
Polymer Science
Shayan S. Nazari, Andrew D. Doyle, Kenneth M. Yamada
Summary: Through a 3D in vitro model, it was found that human cancer cells primarily use proteolysis and actin polymerization to breach the basement membrane and expand perforations, with relatively small contribution from myosin II contractility.
Article
Toxicology
Gerrit Bredeck, Jochen Dobner, Burkhard Stahlmecke, Khanneh Wadinga Fomba, Hartmut Herrmann, Andrea Rossi, Roel Schins
Summary: This study aimed to compare the inflammatory response between Saharan dust (SD) and crystalline silica (DQ12), and found that SD has a higher pro-inflammatory potency. This study is important for understanding the mechanisms of respiratory diseases caused by desert dust events.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Article
Respiratory System
Mervi Kreus, Siri Lehtonen, Reetta Hinttala, Johanna Salonen, Katja Porvari, Riitta Kaarteenaho
Summary: This study aimed to evaluate the expression of NHLRC2 mRNA and protein in different cell types of lung tissue samples and investigate the effect of TGF-beta 1 exposure on NHLRC2 expression. The results showed that NHLRC2 was widely expressed in type II pneumocytes, macrophages, bronchiolar epithelium, and hyperplastic alveolar epithelium, and its expression was not regulated by TGF-beta 1 exposure in vitro.
RESPIRATORY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Xuejiao Yang, Honglei Lu, Yinghua Tao, Hongyue Zhang, Huaimin Wang
Summary: This study reports a method to control the fiber alignment, chirality, and stiffness of aromatic peptide hydrogels through heterodimerization of enantiomeric mixtures. The relative ratio of L and D enantiomers can also regulate the adhesion and morphology of mammalian cells. This work provides a new strategy for controlling supramolecular chirality in materials science.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xinming Wang, Valinteshley Pierre, Chao Liu, Subhadip Senapati, Paul S. -H. Park, Samuel E. Senyo
Summary: The study found that injectable fetal-derived dECM hydrogel treatment can reduce fibroblast activation and contractility, and alleviate stiffness-mediated fibroblast activation in stiffened tissues. The anti-fibrotic effect of this hydrogel is most pronounced at the highest stiffness levels.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Engineering, Biomedical
Qingli Liu, Wenling Dai, Yongli Gao, Longpeng Dong, Hengxing Jia, Shikui Li, Likun Guo, Yujiang Fan, Xingdong Zhang
Summary: The physicochemical properties of collagen-based hydrogels and co-culture system have synergistic effects on cartilage formation. The spreading and proliferation of cells are regulated by the degradation rate and stiffness of hydrogels. Co-culture cells in collagen-based hydrogels significantly improve chondrogenesis.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Heng-Hua Hsu, Ping-Liang Ko, Chien-Chung Peng, Ya-Jen Cheng, Hsiao-Mei Wu, Yi-Chung Tung
Summary: In this paper, a microfluidic device is developed to study the sprouting angiogenesis of endothelial cells under oxygen gradients and co-culture of fibroblast cells. The device integrates a hydrogel matrix for cell culture and generates stable oxygen gradients using a chemical reaction method. The results show that the oxygen gradient and co-culture of fibroblast cells promote sprouting of endothelial cells by altering cytokines and hydrogel properties. This device provides a powerful in vitro model to investigate sprouting angiogenesis under in vivo-like microenvironments.
MATERIALS TODAY BIO
(2023)
Article
Materials Science, Biomaterials
Michela Licciardello, Viola Sgarminato, Gianluca Ciardelli, Chiara Tonda-Turo
Summary: This study developed two biomimetic in vitro models using tissue engineering approaches to mimic the physiological features of the alveolar-capillary barrier. The models were able to accurately reproduce the characteristics of the barrier and could be used for testing and validation of therapeutic approaches for lung disease.
BIOMATERIALS ADVANCES
(2023)
Article
Food Science & Technology
Junmei Wang, Ziqi Yue, Li Che, Hui Li, Rui Hu, Liyuan Shi, Xiaohong Zhang, Huawei Zou, Quanhui Peng, Yahui Jiang, Zhisheng Wang
Summary: This study found that LPS inhibited cell proliferation and induced ECM degradation and inflammatory response in SV40T-YFB, a yak rumen fibroblast cell line.
Review
Biochemistry & Molecular Biology
Victoria A. Ptasinski, John Stegmayr, Maria G. Belvisi, Darcy E. Wagner, Lynne A. Murray
Summary: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease initiated by repeated epithelial injuries, leading to abnormal wound healing responses. Targeting the regenerative capacity of lung epithelium is crucial for developing novel therapies for IPF, which involves coordinated cross-talk among multiple cell types and reestablishment of a normal extracellular matrix environment.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Oncology
Adina R. D. Jensen, Edward R. Horton, Lene H. Blicher, Elin J. Pietras, Cornelia Steinhauer, Raphael Reuten, Erwin M. Schoof, Janine T. Erler
Summary: This study examines the interaction between breast cancer cells and protein scaffolds from different organs, as well as the importance of conducting drug screening in a more physiological context.
Editorial Material
Pediatrics
Joyce R. Javier, Vivek Balasubramaniam
PEDIATRIC RESEARCH
(2018)
Correction
Pediatrics
Joyce R. Javier, Vivek Balasubramaniam
PEDIATRIC RESEARCH
(2019)
Editorial Material
Pediatrics
Shetal Shah, Heather L. Brumberg, Alice Kuo, Vivek Balasubramaniam, Shale Wong, Valerie Opipari
JOURNAL OF PEDIATRICS
(2019)
Article
Cardiac & Cardiovascular Systems
Tova L. Ceccato, Rachel B. Starbuck, Jessica K. Hall, Cierra J. Walker, Tobin E. Brown, Jason P. Killgore, Kristi S. Anseth, Leslie A. Leinwand
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Review
Primary Health Care
Ariel Kiyomi Daoud, Jessica Kole Hall, Haylie Petrick, Anne Strong, Cleveland Piggott
Summary: The review found that cloth masks have some efficacy in filtering particulate matter and aerosols, but they provide a worse fit and inferior protection compared to medical masks in clinical environments. There is a lack of evidence supporting cloth masks for adequate protection of health care clinicians against respiratory viral infections.
ANNALS OF FAMILY MEDICINE
(2021)
Editorial Material
Psychology, Developmental
Emily Ruedinger, Yolanda N. Evans, Vivek Balasubramaniam
JOURNAL OF ADOLESCENT HEALTH
(2021)
Editorial Material
Pediatrics
Vivek Balasubramaniam, Lois K. Lee, Joyce R. Javier
PEDIATRIC RESEARCH
(2021)
Article
Oncology
Elena Shagisultanova, Lyndsey S. Crump, Michelle Borakove, Jessica K. Hall, Aryana R. Rasti, Benjamin A. Harrison, Peter Kabos, Traci R. Lyons, Virginia F. Borges
Summary: This study suggests that triple targeted combination therapy with tucatinib, palbociclib, and fulvestrant effectively inhibits the growth of HR+/HER2(+) breast cancer cells and prevents the development of drug-resistant subclones. It demonstrates significant tumoricidal activity and provides a potential clinical strategy for the treatment of otherwise drug-resistant tumors.
MOLECULAR CANCER THERAPEUTICS
(2022)
Letter
Obstetrics & Gynecology
Amy Markese, Shawna Tonick, Alida O. Leavitt, Jessica Hall, Margo S. Harrison
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Editorial Material
Surgery
Bartley Pickron, Luke Martin, Alexandria Tran, Jessica Hall
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Alyssa E. Vaughn, Jessica K. Hall, Madison L. Harrison, Glendalyn Klein, Jose Diaz-Miron, Jeniann A. Yi, Shannon N. Acker
Summary: Pediatric iliofemoral arterial thrombosis primarily occurs in infants and is effectively treated with heparin or enoxaparin, rarely requiring surgical intervention and rarely associated with long-term complications.
Article
Health Policy & Services
Jessica K. Hall, Isabelle C. Chatroux, Lindsey E. Fish
Summary: The report discusses an innovative urban hospital-affiliated federally qualified health center urgent care clinic that effectively provides accessible, appropriate, and affordable acute care for medically underserved patients.
JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
(2021)
Article
Respiratory System
Devika R. Rao, Benjamin Kopp, Rory John Kamerman-Kretzmer, Folashade Afolabi, Deborah R. Liptzin, Vivek Balasubramaniam, S. Christy Sadreameli
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Otorhinolaryngology
Nainika Nanda, Brady Hauser, Diane Heatley, Vivek Balasubramaniam, Christina B. Barreda
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2020)
Article
Oncology
Kimberly R. Jordan, Jessica K. Hall, Troy Schedin, Michelle Borakove, Jenny J. Xian, Monika Dzieciatkowska, Traci R. Lyons, Pepper Schedin, Kirk C. Hansen, Virginia F. Borges
BREAST CANCER RESEARCH
(2020)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.