Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease

Mechanisms and function of autophagy in intestinal disease

(2018) Kara G. Lassen et al.   Autophagy

Autophagy and inflammation in chronic respiratory disease

(2018) Alexandra C. Racanelli et al.   Autophagy

Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii -Mediated Inflammation

(2018) Elise Burger et al.   Cell Host & Microbe

Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice

(2018) Johanna Pott et al.   Cell Host & Microbe

Paneth Cells and their Antimicrobials in Intestinal Immunity

(2018) Timon E. Adolph et al.   CURRENT PHARMACEUTICAL DESIGN

Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn’s Disease

(2018) Lee A. Denson et al.   GASTROENTEROLOGY

Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency

(2018) Eduardo R. Cobo et al.   INFECTION AND IMMUNITY

Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn’s disease

(2018) Liming Mao et al.   JOURNAL OF CLINICAL INVESTIGATION

Lactobacillus acidophilus suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress

(2018) Da Hye Kim et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

(2018) Mohammad Samie et al.   NATURE IMMUNOLOGY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Innate immune functions of avian intestinal epithelial cells: Response to bacterial stimuli and localization of responding cells in the developing avian digestive tract

(2018) Enav Bar Shira et al.   PLoS One

Inflammasome, Inflammation, and Tissue Homeostasis

(2018) Vijay A.K. Rathinam et al.   TRENDS IN MOLECULAR MEDICINE

TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival

(2018) Lele Zhu et al.   Nature Communications

Association Between Autophagy and Neurodegenerative Diseases

(2018) Nobuhiro Fujikake et al.   Frontiers in Neuroscience

Lipopolysaccharide-Induced Dephosphorylation of AMPK-Activated Protein Kinase Potentiates Inflammatory Injury via Repression of ULK1-Dependent Autophagy

(2018) Kerui Fan et al.   Frontiers in Immunology

The Antioxidant Procyanidin Reduces Reactive Oxygen Species Signaling in Macrophages and Ameliorates Experimental Colitis in Mice

(2018) Lu Chen et al.   Frontiers in Immunology

Oxidative stress-elicited autophagosome accumulation contributes to human neuroblastoma SH-SY5Y cell death induced by PBDE-47

(2017) Cheng Zhang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Paneth Cell Alterations in the Development and Phenotype of Crohn’s Disease

(2017) Thaddeus S. Stappenbeck et al.   GASTROENTEROLOGY

The protection role of Atg16l1 in CD11c + dendritic cells in murine colitis

(2017) Hong Zhang et al.   IMMUNOBIOLOGY

An Overview of the Innate and Adaptive Immune System in Inflammatory Bowel Disease

(2017) Matthew C. Choy et al.   INFLAMMATORY BOWEL DISEASES

Apple Polysaccharide inhibits microbial dysbiosis and chronic inflammation and modulates gut permeability in HFD-fed rats

(2017) Sheng Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A possible differential role of autophagy in asthma?

(2017) Ulaganathan Mabalirajan   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Probiotics are a good choice in remission of inflammatory bowel diseases: A meta analysis and systematic review

(2017) Mahboube Ganji-Arjenaki et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloid ATG16L1 Facilitates Host–Bacteria Interactions in Maintaining Intestinal Homeostasis

(2017) Hong Zhang et al.   JOURNAL OF IMMUNOLOGY

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

(2017) Shai Bel et al.   SCIENCE

Role of autophagy in the pathogenesis of inflammatory bowel disease

(2017) Tomoya Iida et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease

(2017) Ping Ke et al.   Frontiers in Immunology

Increased Autophagy-Related 5 Gene Expression Is Associated with Collagen Expression in the Airways of Refractory Asthmatics

(2017) Audrey H. Poon et al.   Frontiers in Immunology

The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes

(2016) Takashi Nozawa et al.   Autophagy

An unconventional pathway for mitochondrial protein degradation

(2016) Zhiyuan Yao et al.   Autophagy

Links of Autophagy Dysfunction to Inflammatory Bowel Disease Onset

(2016) Faris El-Khider et al.   DIGESTIVE DISEASES

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

(2016) Tobias Schwerd et al.   GUT

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

(2016) Kara G. Lassen et al.   IMMUNITY

NOD2 induces autophagy to control AIEC bacteria infectiveness in intestinal epithelial cells

(2016) Anna Negroni et al.   INFLAMMATION RESEARCH

Precision autophagy directed by receptor regulators – emerging examples within the TRIM family

(2016) Tomonori Kimura et al.   JOURNAL OF CELL SCIENCE

Inflammatory Bowel Disease Drugs: A Focus on Autophagy

(2016) Kirsty M. Hooper et al.   Journal of Crohns & Colitis

Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease

(2016) E M Giles et al.   Mucosal Immunology

Defective noncanonical autophagy in SLE-like disease

(2016) Susan J. Allison   Nature Reviews Rheumatology

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

(2016) H. Chu et al.   SCIENCE

Autophagy Beyond Intracellular MHC Class II Antigen Presentation

(2016) Christian Münz   TRENDS IN IMMUNOLOGY

FoxO1-mediated autophagy is required for NK cell development and innate immunity

(2016) Shuo Wang et al.   Nature Communications

Atg5 Is Essential for the Development and Survival of Innate Lymphocytes

(2016) Timothy E. O’Sullivan et al.   Cell Reports

The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models

(2016) IoanaMiruna Balmus et al.   Saudi Journal of Gastroenterology

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

(2016) Odile Wéra et al.   Journal of Clinical Medicine

Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages

(2016) Ping Ke et al.   PLoS One

Autophagy in airway diseases: a new frontier in human asthma?

(2015) A. A. Zeki et al.   ALLERGY

VDR/vitamin D receptor regulates autophagic activity through ATG16L1

(2015) Jun Sun   Autophagy

Autophagy and inflammatory bowel disease: Association between variants of the autophagy-related IRGM gene and susceptibility to Crohn's disease

(2015) Sara Rufini et al.   DIGESTIVE AND LIVER DISEASE

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

(2015) T. S. Chew et al.   Disease Models & Mechanisms

Role of Autophagy in the Maintenance of Intestinal Homeostasis

(2015) Leigh A. Baxt et al.   GASTROENTEROLOGY

Role of Inflammasomes in Intestinal Inflammation and Crohnʼs Disease

(2015) Anthony Opipari et al.   INFLAMMATORY BOWEL DISEASES

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

(2015) Tomonori Kimura et al.   JOURNAL OF CELL BIOLOGY

Immunologic manifestations of autophagy

(2015) Vojo Deretic et al.   JOURNAL OF CLINICAL INVESTIGATION

Invariant NKT Cells Require Autophagy To Coordinate Proliferation and Survival Signals during Differentiation

(2015) Bo Pei et al.   JOURNAL OF IMMUNOLOGY

Atg5 but not Atg7 in dendritic cells enhances IL-2 and IFN-γ production by Toxoplasma gondii-reactive CD4+ T cells

(2015) Elizabeth Liu et al.   MICROBES AND INFECTION

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

The unusual suspects—innate lymphoid cells as novel therapeutic targets in IBD

(2015) Rimma Goldberg et al.   Nature Reviews Gastroenterology & Hepatology

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

(2015) Min Zhang et al.   eLife

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Is the Intestinal Goblet Cell a Major Immune Cell?

(2014) Malin E.V. Johansson et al.   Cell Host & Microbe

Melatonin, Autophagy and Intestinal Bowel Disease

(2014) Elena Talero et al.   CURRENT PHARMACEUTICAL DESIGN

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

(2014) Aleksandar D. Kostic et al.   GASTROENTEROLOGY

XIAP variants in male Crohn's disease

(2014) Yvonne Zeissig et al.   GUT

Oral Tolerance Can Be Established via Gap Junction Transfer of Fed Antigens from CX3CR1+ Macrophages to CD103+ Dendritic Cells

(2014) Elisa Mazzini et al.   IMMUNITY

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

TCF1 regulates Paneth cell α-defensins

(2014) Gillian Patman   Nature Reviews Gastroenterology & Hepatology

Chronic Oxidative Stress Increases Growth and Tumorigenic Potential of MCF-7 Breast Cancer Cells

(2014) Prathap Kumar S. Mahalingaiah et al.   PLoS One

Loss of Sonic Hedgehog Leads to Alterations in Intestinal Secretory Cell Maturation and Autophagy

(2014) Jessica Gagné-Sansfaçon et al.   PLoS One

Essential role for autophagy during invariant NKT cell development

(2014) Mariolina Salio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

(2013) Khushbu K Patel et al.   EMBO JOURNAL

XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling

(2013) Xing Huang et al.   EMBO JOURNAL

ATG16L1Crohn's disease risk stresses the endoplasmic reticulum of Paneth cells

(2013) Arthur Kaser et al.   GUT

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

(2013) Christopher Lupfer et al.   NATURE IMMUNOLOGY

TLR-induced PAI-2 expression suppresses IL-1  processing via increasing autophagy and NLRP3 degradation

(2013) S.-Y. Chuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response

(2012) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

Complex Roles of Caspases in the Pathogenesis of Inflammatory Bowel Disease

(2012) Christoph Becker et al.   GASTROENTEROLOGY

Impaired autophagy leads to abnormal dendritic cell–epithelial cell interactions

(2012) Caterina Strisciuglio et al.   Journal of Crohns & Colitis

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Autophagy, Microbial Sensing, Endoplasmic Reticulum Stress, and Epithelial Function in Inflammatory Bowel Disease

(2011) Arthur Kaser et al.   GASTROENTEROLOGY

Recent Insights Into the Genetics of Inflammatory Bowel Disease

(2011) Judy H. Cho et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Crohn's disease: NOD2, autophagy and ER stress converge

(2011) T. Fritz et al.   GUT

Regulation of the Antimicrobial Response by NLR Proteins

(2011) Eran Elinav et al.   IMMUNITY

Intracellular recognition of pathogens and autophagy as an innate immune host defence

(2011) T. Yano et al.   JOURNAL OF BIOCHEMISTRY

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Homeostasis and Inflammation in the Intestine

(2010) Wendy S. Garrett et al.   CELL

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Common Genetic Variation and Human Traits

(2009) David B. Goldstein   NEW ENGLAND JOURNAL OF MEDICINE

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS