Inflammatory Bowel Disease Drugs: A Focus on Autophagy

P057. HLA B27 transgenic rat: a new animal model of postsurgical ileitis in inflammatory bowel disease

(2016)   Journal of Crohns & Colitis

OP005. A variable number of tandem repeat polymorphism in the promotor region of the neonatal Fc receptor affects anti-tumour necrosis factor serum levels in inflammatory bowel disease

(2016)   Journal of Crohns & Colitis

NOD1 and NOD2 signalling links ER stress with inflammation

(2016) A. Marijke Keestra-Gounder et al.   NATURE

Comparison of the therapeutic efficacy and safety between tacrolimus and infliximab for moderate-to-severe ulcerative colitis: a single center experience

(2016) Yoichiro Nuki et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Tumor necrosis factor alpha stimulates p62 accumulation and enhances proteasome activity independently of ROS

(2015) Caleigh M. Opperman et al.   CELL BIOLOGY AND TOXICOLOGY

Tailoring Treatment to the Individual Patient - Will Inflammatory Bowel Disease Medicine Be Personalized?

(2015) Claudio Fiocchi   DIGESTIVE DISEASES

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

P042. Response to corticosteroids in Ulcerative Colitis may be related to modulation of mTOR signaling pathway genes by microRNAs

(2015)   Journal of Crohns & Colitis

Use of Biosimilars in Paediatric Inflammatory Bowel Disease

(2015) Lissy de Ridder et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: Effect of N-acetyl transferase polymorphisms

(2015) Gabriele Stocco   WORLD JOURNAL OF GASTROENTEROLOGY

The gap between scientific evidence and clinical practice: 5-aminosalicylates are frequently used for the treatment of Crohn's disease

(2014) A. M. Schoepfer et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Sulfasalazine Induces Autophagic Cell Death in Oral Cancer Cells via Akt and ERK Pathways

(2014) Hye-Yeon Han et al.   Asian Pacific Journal of Cancer Prevention

Autophagy protects renal tubular cells against cyclosporine toxicity

(2014) Nicolas Pallet et al.   Autophagy

Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes

(2014) Sarah Swerdlow et al.   Autophagy

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

(2014) Yongjie Wei et al.   Autophagy

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells

(2014) Di Ge et al.   Autophagy

Pharmacological Strategies in Lung Cancer-Induced Cachexia: Effects on Muscle Proteolysis, Autophagy, Structure, and Weakness

(2014) Alba Chacon-Cabrera et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

Cyclosporine A Induces Apoptotic and Autophagic Cell Death in Rat Pituitary GH3 Cells

(2014) Han Sung Kim et al.   PLoS One

Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases

(2014) Aurelien Amiot et al.   Therapeutic Advances in Gastroenterology

Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

(2013) Bo Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice

(2013) Takehiro Nakagaki et al.   Autophagy

Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress

(2013) Tomonori Kimura et al.   Autophagy

Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease

(2013) J Jasper Deuring et al.   GUT

Challenges in IBD Research

(2013) Lee A. Denson et al.   INFLAMMATORY BOWEL DISEASES

T300A Variant of Autophagy ATG16L1 Gene is Associated with Decreased Antigen Sampling and Processing by Dendritic Cells in Pediatric Crohnʼs Disease

(2013) Caterina Strisciuglio et al.   INFLAMMATORY BOWEL DISEASES

Corticosteroids Block Autophagy Protein Recruitment in Aspergillus fumigatus Phagosomes via Targeting Dectin-1/Syk Kinase Signaling

(2013) I. Kyrmizi et al.   JOURNAL OF IMMUNOLOGY

Quantitative Proteomics Reveals the Induction of Mitophagy in Tumor Necrosis Factor-α-activated (TNFα) Macrophages

(2013) Christina Bell et al.   MOLECULAR & CELLULAR PROTEOMICS

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Autophagy: a new target or an old strategy for the treatment of Crohn's disease?

(2013) Kris Nys et al.   Nature Reviews Gastroenterology & Hepatology

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy Induced by Tumor Necrosis Factor α Mediates Intrinsic Apoptosis in Trophoblastic Cells

(2013) Hyun-Hwa Cha et al.   Reproductive Sciences

Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells

(2012) Jing Zhou et al.   Autophagy

Is the Autophagy Induced by Thiopurines Beneficial or Deleterious?

(2012) Luis G. Guijarro et al.   CURRENT DRUG METABOLISM

Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History

(2012) J. Annelies E. Polman et al.   ENDOCRINOLOGY

Hospitalisations and surgery in Crohn's disease

(2012) Charles N Bernstein et al.   GUT

Management of Pediatric Ulcerative Colitis

(2012) Dan Turner et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine A-induced cell death

(2012) I A Ciechomska et al.   ONCOGENE

Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

(2012) E. F. Castillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts

(2012) Alison M Connor et al.   ARTHRITIS RESEARCH & THERAPY

Aminosalicylates

(2011) Christoph Campregher et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

NOD2 Polymorphism Predicts Response to Treatment in Crohn’s Disease—First Steps to a Personalized Therapy

(2011) Jan Hendrik Niess et al.   DIGESTIVE DISEASES AND SCIENCES

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2

(2011) T. S. Plantinga et al.   GUT

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

(2011) Patrick Brest et al.   NATURE GENETICS

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

Autophagy Is Activated in Injured Neurons and Inhibited by Methylprednisolone After Experimental Spinal Cord Injury

(2011) Hsien-Chih Chen et al.   SPINE

Common misconceptions about 5-aminosalicylates and thiopurines in inflammatory bowel disease

(2011) Javier P Gisbert   WORLD JOURNAL OF GASTROENTEROLOGY

ER stress and the unfolded protein response in intestinal inflammation

(2010) Michael A. McGuckin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Glucocorticoids downregulate Fyn and inhibit IP3-mediated calcium signaling to promote autophagy in T lymphocytes

(2010) Michael W. Harr et al.   Autophagy

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

How tumour necrosis factor blockers interfere with tuberculosis immunity

(2010) J. Harris et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

TNF-α Induces Macroautophagy and Regulates MHC Class II Expression in Human Skeletal Muscle Cells

(2010) Christian W. Keller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid-induced autophagy in osteocytes

(2010) Xuechun Xia et al.   JOURNAL OF BONE AND MINERAL RESEARCH

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

(2009) E Laane et al.   CELL DEATH AND DIFFERENTIATION

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides

(2008) Sharon J. Gardiner et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

(2008) D C O Massey et al.   GUT

Autophagy and pattern recognition receptors in innate immunity

(2008) Monica Delgado et al.   IMMUNOLOGICAL REVIEWS

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS

Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes

(2007) Elise Petit et al.   TOXICOLOGY IN VITRO