Precision autophagy directed by receptor regulators – emerging examples within the TRIM family

Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

(2015) Carlos T. Pineda et al.   CELL

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

(2015) Gen Matsumoto et al.   HUMAN MOLECULAR GENETICS

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation

(2015) Zhifang Cao et al.   IMMUNITY

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

(2015) Tomonori Kimura et al.   JOURNAL OF CELL BIOLOGY

Immunologic manifestations of autophagy

(2015) Vojo Deretic et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis

(2015) Richard S. Marshall et al.   MOLECULAR CELL

PI(5)P Regulates Autophagosome Biogenesis

(2015) Mariella Vicinanza et al.   MOLECULAR CELL

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

TRIM25 has a dual function in the p53/Mdm2 circuit

(2015) P Zhang et al.   ONCOGENE

Activating MET kinase rearrangements in melanoma and Spitz tumours

(2015) Iwei Yeh et al.   Nature Communications

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

PML/TRIM19-Dependent Inhibition of Retroviral Reverse-Transcription by Daxx

(2015) Jacques Dutrieux et al.   PLoS Pathogens

The effects of p53 on whole organism longevity are mediated by autophagy

(2014) Nektarios Tavernarakis et al.   Autophagy

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family

(2014) Kefeng Lu et al.   CELL

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

(2014) Ju Liu et al.   CELL DEATH AND DIFFERENTIATION

Self and Nonself: How Autophagy Targets Mitochondria and Bacteria

(2014) Felix Randow et al.   Cell Host & Microbe

TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

(2014) Michael A. Mandell et al.   DEVELOPMENTAL CELL

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1

(2014) Seung-Hyun Ro et al.   FEBS Journal

TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53

(2014) Zhicheng Zhou et al.   GASTROENTEROLOGY

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

(2014) R. Higgs et al.   JOURNAL OF IMMUNOLOGY

Nucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 Stabilization

(2014) B. Ashok Reddy et al.   MOLECULAR CELL

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Anchored multiplex PCR for targeted next-generation sequencing

(2014) Zongli Zheng et al.   NATURE MEDICINE

TRIpartite Motif 21 (TRIM21) Differentially Regulates the Stability of Interferon Regulatory Factor 5 (IRF5) Isoforms

(2014) Elisa Lazzari et al.   PLoS One

Microtubule-Associated Protein 1 Light Chain 3 Interacts with and Contributes to Growth Inhibiting Effect of PML

(2014) Wei He et al.   PLoS One

Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence

(2014) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody- and TRIM21-dependent intracellular restriction ofSalmonella enterica

(2014) Nikolas Rakebrandt et al.   Pathogens and Disease

Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors

(2013) Muzamil Majid Khan et al.   Autophagy

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

FIP200 regulates targeting of Atg16L1 to the isolation membrane

(2013) Taki Nishimura et al.   EMBO REPORTS

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors

(2013) Gijs A. Versteeg et al.   IMMUNITY

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

(2013) Naonobu Fujita et al.   JOURNAL OF CELL BIOLOGY

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

(2013) Ruisheng Song et al.   NATURE

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

(2013) Adam Collison et al.   NATURE MEDICINE

MURF2B, a Novel LC3-Binding Protein, Participates with MURF2A in the Switch between Autophagy and Ubiquitin Proteasome System during Differentiation of C2C12 Muscle Cells

(2013) Véronique Pizon et al.   PLoS One

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

(2013) I. Barde et al.   SCIENCE

Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy

(2013) Jonathan Zirin et al.   PLOS BIOLOGY

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome

(2013) Gaëlle Blandin et al.   Skeletal Muscle

A reverse-ELISA for the detection of TRIM28/KAP1 serum autoantibodies in colorectal cancer patients

(2012) Suzanne Hector et al.   ACTA ONCOLOGICA

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

TRIM8 modulates p53 activity to dictate cell cycle arrest

(2012) Mariano Francesco Caratozzolo et al.   CELL CYCLE

The Autophagy Regulator Rubicon Is a Feedback Inhibitor of CARD9-Mediated Host Innate Immunity

(2012) Chul-Su Yang et al.   Cell Host & Microbe

Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC

(2012) Nicole C McKnight et al.   EMBO JOURNAL

Pex3-anchored Atg36 tags peroxisomes for degradation inSaccharomyces cerevisiae

(2012) Alison M Motley et al.   EMBO JOURNAL

Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival MitophagyversusApoptosis

(2012) Yanyan Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells

(2012) T. Sato et al.   JOURNAL OF CELL SCIENCE

NBR1 acts as an autophagy receptor for peroxisomes

(2012) E. Deosaran et al.   JOURNAL OF CELL SCIENCE

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex–dependent and –independent autophagy

(2012) Noor Gammoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRIM16 Acts as an E3 Ubiquitin Ligase and Can Heterodimerize with Other TRIM Family Members

(2012) Jessica L. Bell et al.   PLoS One

The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

(2012) Carmela Fusco et al.   PLoS One

TBK1 Kinase Addiction in Lung Cancer Cells Is Mediated via Autophagy of Tax1bp1/Ndp52 and Non-Canonical NF-κB Signalling

(2012) Alice C. Newman et al.   PLoS One

TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitylation of p53 by the APC/C inhibitor Trim39

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoantibodies to transcription intermediary factor (TIF)1β associated with dermatomyositis

(2012) Minoru Satoh et al.   ARTHRITIS RESEARCH & THERAPY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins

(2011) Manabu Fujimoto et al.   ARTHRITIS AND RHEUMATISM

Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein

(2011) Zhuo Wang et al.   Autophagy

Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1

(2011) Sixin Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells

(2011) Dhanendra Tomar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome Assembly

(2011) Brian O. Bodemann et al.   CELL

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

(2011) Trond Lamark et al.   CELL CYCLE

LC3 and GATE-16 N Termini Mediate Membrane Fusion Processes Required for Autophagosome Biogenesis

(2011) Hilla Weidberg et al.   DEVELOPMENTAL CELL

Inhibition of autophagy by TAB2 and TAB3

(2011) Alfredo Criollo et al.   EMBO JOURNAL

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

(2011) Taro Kawai et al.   EMBO Molecular Medicine

Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2

(2011) Hae Mi Joo et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

TGF -activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy

(2011) G. Takaesu et al.   JOURNAL OF BIOCHEMISTRY

Toward an understanding of the protein interaction network of the human liver

(2011) J. Wang et al.   Molecular Systems Biology

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish

(2011) Pierre Boudinot et al.   PLoS One

Tripartite motif 8 (TRIM8) modulates TNF - and IL-1 -triggered NF- B activation by targeting TAK1 for K63-linked polyubiquitination

(2011) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Asthma-Predictive Genetic Markers in Gene Expression Profiling of Peripheral Blood Mononuclear Cells

(2011) Seung Woo Shin et al.   Allergy Asthma & Immunology Research

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

(2010) Terje Høyvarde Clausen et al.   Autophagy

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

(2010) P. Isakson et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Autoantibodies to GW bodies and other autoantigens in primary biliary cirrhosis

(2010) L. M. Stinton et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover

(2010) Sue Perera et al.   DEVELOPMENTAL BIOLOGY

Fas-associated Death Domain (FADD) and the E3 Ubiquitin-Protein Ligase TRIM21 Interact to Negatively Regulate Virus-induced Interferon Production

(2010) Jennifer A. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/Sequestosome-1 Associates with and Sustains the Expression of Retroviral Restriction Factor TRIM5 

(2010) C. O'Connor et al.   JOURNAL OF VIROLOGY

The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions

(2010) Z. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

(2010) Maria Filimonenko et al.   MOLECULAR CELL

Downregulation of active IKKβ by Ro52-mediated autophagy

(2010) Motoko Niida et al.   MOLECULAR IMMUNOLOGY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

(2010) Sudha B. Singh et al.   NATURE CELL BIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Self Protection from Anti-Viral Responses – Ro52 Promotes Degradation of the Transcription Factor IRF7 Downstream of the Viral Toll-Like Receptors

(2010) Rowan Higgs et al.   PLoS One

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hexagonal assembly of a restricting TRIM5  protein

(2010) B. K. Ganser-Pornillos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABAA receptors

(2010) C. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy

(2009) Melanie Schwarten et al.   Autophagy

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

(2009) Koji Okamoto et al.   DEVELOPMENTAL CELL

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer

(2009) G Kijanka et al.   GUT

Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

(2009) Serhiy Pankiv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

(2009) Alexander Espinosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gene Disruption Study Reveals a Nonredundant Role for TRIM21/Ro52 in NF- B-Dependent Cytokine Expression in Fibroblasts

(2009) R. Yoshimi et al.   JOURNAL OF IMMUNOLOGY

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Human TRIM Gene Expression in Response to Interferons

(2009) Laetitia Carthagena et al.   PLoS One

Trim24 targets endogenous p53 for degradation

(2009) Kendra Allton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy: Basic Principles and Relevance to Disease

(2008) Mondira Kundu et al.   Annual Review of Pathology-Mechanisms of Disease

Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties

(2008) Marco Sardiello et al.   BMC EVOLUTIONARY BIOLOGY

Downregulation of the Spi-1/PU.1 oncogene induces the expression of TRIM10/HERF1, a key factor required for terminal erythroid cell differentiation and survival

(2008) Rand Blaybel et al.   CELL RESEARCH

PpAtg30 Tags Peroxisomes for Turnover by Selective Autophagy

(2008) Jean-Claude Farré et al.   DEVELOPMENTAL CELL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

MG53 nucleates assembly of cell membrane repair machinery

(2008) Chuanxi Cai et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

(2008) Rihab Nasr et al.   NATURE MEDICINE