Role of Inflammasomes in Intestinal Inflammation and Crohnʼs Disease

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Mining the Human Gut Microbiota for Effector Strains that Shape the Immune System

(2014) Philip P. Ahern et al.   IMMUNITY

Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome

(2014) Marjorie De la Fuente et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2

(2014) N. Marina-Garcia et al.   JOURNAL OF IMMUNOLOGY

Inflammasome activation has an important role in the development of spontaneous colitis

(2014) J Zhang et al.   Mucosal Immunology

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

(2014) Antonella de Luca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkcδ

(2014) Shiho Suzuki et al.   PLoS Pathogens

The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases

(2013) Vassilis Valatas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inflammasomes in inflammatory bowel disease pathogenesis

(2013) Ling-Yang Hao et al.   CURRENT OPINION IN GASTROENTEROLOGY

Of inflammasomes and pathogens - sensing of microbes by the inflammasome

(2013) Franz Bauernfeind et al.   EMBO Molecular Medicine

Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice

(2013) Marina Bersudsky et al.   GUT

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

(2013) Haitao Wen et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

(2013) Robert van der Burgh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nlrp3 inflammasome regulates acute graft-versus-host disease

(2013) Dragana Jankovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induced IL-17-Producing Invariant NKT Cells Require Activation in Presence of TGF-  and IL-1 

(2013) M. Monteiro et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein

(2013) M. Rayamajhi et al.   JOURNAL OF IMMUNOLOGY

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

(2013) Christopher Lupfer et al.   NATURE IMMUNOLOGY

Control of pathogens and pathobionts by the gut microbiota

(2013) Nobuhiko Kamada et al.   NATURE IMMUNOLOGY

TLR-induced PAI-2 expression suppresses IL-1  processing via increasing autophagy and NLRP3 degradation

(2013) S.-Y. Chuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

(2013) Z. Hu et al.   SCIENCE

From genetics of inflammatory bowel disease towards mechanistic insights

(2013) Daniel B. Graham et al.   TRENDS IN IMMUNOLOGY

Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease

(2013) Loris R. Lopetuso et al.   Frontiers in Immunology

Recognition of Bacteria by Inflammasomes

(2012) Jakob von Moltke et al.   Annual Review of Immunology

Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors

(2012) Christian Bauer et al.   DIGESTIVE DISEASES

Role of Inflammasomes in Host Defense againstCitrobacter rodentiumInfection

(2012) Zhiping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

(2012) Margherita Coccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice

(2012) Carles Ubeda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protective Role of Commensals against Clostridium difficile Infection via an IL-1 -Mediated Positive-Feedback Loop

(2012) M. Hasegawa et al.   JOURNAL OF IMMUNOLOGY

Integrative inflammasome activity in the regulation of intestinal mucosal immune responses

(2012) E Elinav et al.   Mucosal Immunology

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

(2012) Paras K. Anand et al.   NATURE

Phosphorylation of NLRC4 is critical for inflammasome activation

(2012) Yan Qu et al.   NATURE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Reciprocal interactions of the intestinal microbiota and immune system

(2012) Craig L. Maynard et al.   NATURE

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Inflammasomes: far beyond inflammation

(2012) Jorge Henao-Mejia et al.   NATURE IMMUNOLOGY

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Enterohemorrhagic Escherichia coli Specific Enterohemolysin Induced IL-1β in Human Macrophages and EHEC-Induced IL-1β Required Activation of NLRP3 Inflammasome

(2012) Xiaoai Zhang et al.   PLoS One

ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation

(2011) Theo S. Plantinga et al.   Autophagy

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes

(2011) V. U. Ozkurede et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inflammasomes in Intestinal Inflammation and Cancer

(2011) Grace Y. Chen et al.   GASTROENTEROLOGY

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2

(2011) T. S. Plantinga et al.   GUT

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-1-Processed Cytokines IL-1  and IL-18 Promote IL-17 Production by    and CD4 T Cells That Mediate Autoimmunity

(2011) S. J. Lalor et al.   JOURNAL OF IMMUNOLOGY

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

(2011) S. Normand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excessive interleukin-1 signaling determines the development of Th1 and Th17 responses in chronic inflammation

(2010) Leo A. B. Joosten   ARTHRITIS AND RHEUMATISM

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

Genetic association between NLRP3 variants and Crohnʼs disease does not replicate in a large UK panel

(2010) Gregory J. Lewis et al.   INFLAMMATORY BOWEL DISEASES

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

(2010) Simon A. Hirota et al.   INFLAMMATORY BOWEL DISEASES

Interleukin 1 β (IL-1B) and IL-1 Antagonist Receptor (IL-1RN) Gene Polymorphisms are Associated With the Genetic Susceptibility and Steroid Dependence in Patients With Ulcerative Colitis

(2010) Jesús K. Yamamoto-Furusho et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis

(2010) Ting Feng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blocking interleukin-1β in acute and chronic autoinflammatory diseases

(2010) C. A. Dinarello   JOURNAL OF INTERNAL MEDICINE

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

(2010) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined Polymorphisms in Genes Encoding the Inflammasome Components NALP3 and CARD8 Confer Susceptibility to Crohn's Disease in Swedish Men

(2009) Ida Schoultz et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

Interleukin-1 Receptor Signaling Protects Mice from Lethal Intestinal Damage Caused by the Attaching and Effacing Pathogen Citrobacter rodentium

(2008) S. L. Lebeis et al.   INFECTION AND IMMUNITY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA