NOD2 induces autophagy to control AIEC bacteria infectiveness in intestinal epithelial cells

Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasiveEscherichia coliinfection

(2016) Alexis Bretin et al.   Autophagy

ATG16L1: A multifunctional susceptibility factor in Crohn disease

(2015) Mohammad Salem et al.   Autophagy

TheATG16L1–T300Aallele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients

(2014) Mehdi Sadaghian Sadabad et al.   GUT

Pathogenesis of adherent–invasiveEscherichia coli

(2013) Emma J Smith et al.   Future Microbiology

Crohn's Disease–Associated Adherent Invasive Escherichia coli Modulate Levels of microRNAs in Intestinal Epithelial Cells to Reduce Autophagy

(2013) Hang Thi Thu Nguyen et al.   GASTROENTEROLOGY

The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner

(2013) Matthew T. Sorbara et al.   IMMUNITY

Association between Variants of the Autophagy Related Gene – IRGM and Susceptibility to Crohn’s Disease and Ulcerative Colitis: A Meta-Analysis

(2013) Xiao Cheng Lu et al.   PLoS One

Interplay of autophagy and innate immunity in Crohn's disease: A key immunobiologic feature

(2013) Györgyi Műzes   WORLD JOURNAL OF GASTROENTEROLOGY

Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response

(2012) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

Genetically determined epithelial dysfunction and its consequences for microflora–host interactions

(2011) Arthur Kaser et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease

(2011) Clara Abraham et al.   GASTROENTEROLOGY

IL23R, ATG16L1, IRGM, OCTN1, and OCTN2 mRNA expression in inflamed and noninflamed mucosa of IBD patients

(2011) Orazio Palmieri et al.   INFLAMMATORY BOWEL DISEASES

Digesting the genetics of inflammatory bowel disease: Insights from studies of autophagy risk genes

(2011) Amrita Kabi et al.   INFLAMMATORY BOWEL DISEASES

Characterization of adherent-invasive Escherichia coli isolated from pediatric patients with inflammatory bowel disease

(2011) Anna Negroni et al.   INFLAMMATORY BOWEL DISEASES

High prevalence of aggregative adherent Escherichia coli strains in the mucosa-associated microbiota of patients with inflammatory bowel diseases

(2011) Cristiane M. Thomazini et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease

(2011) W Strober et al.   Mucosal Immunology

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation

(2011) Michael H. Shaw et al.   TRENDS IN IMMUNOLOGY

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

Crohn's Disease Susceptibility Gene Interactions, a NOD to the Newcomer ATG16L1

(2010) Ken Cadwell   GASTROENTEROLOGY

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases

(2010) Daniel N. Frank et al.   INFLAMMATORY BOWEL DISEASES

Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease

(2010) Shadi Sepehri et al.   INFLAMMATORY BOWEL DISEASES

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn disease

(2009) Ken Cadwell et al.   Autophagy

Crohn's disease-associated adherent-invasiveE. coliare selectively favoured by impaired autophagy to replicate intracellularly

(2009) Pierre Lapaquette et al.   CELLULAR MICROBIOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohnʼs disease

(2008) Ben Willing et al.   INFLAMMATORY BOWEL DISEASES

Mucosal NOD2 expression and NF-κB activation in pediatric Crohnʼs disease

(2007) Laura Stronati et al.   INFLAMMATORY BOWEL DISEASES