An Overview of the Innate and Adaptive Immune System in Inflammatory Bowel Disease

Role of Inflammasomes in Intestinal Inflammation and Crohnʼs Disease

(2015) Anthony Opipari et al.   INFLAMMATORY BOWEL DISEASES

The unusual suspects—innate lymphoid cells as novel therapeutic targets in IBD

(2015) Rimma Goldberg et al.   Nature Reviews Gastroenterology & Hepatology

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Th17 plasticity and its changes associated with inflammatory bowel disease

(2015) Aito Ueno   WORLD JOURNAL OF GASTROENTEROLOGY

Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases

(2014) N.-E. Serriari et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Type-2 innate lymphoid cells in human allergic disease

(2014) Jillian L. Barlow et al.   Current Opinion in Allergy and Clinical Immunology

TL1A regulates TCRγδ+intraepithelial lymphocytes and gut microbial composition

(2014) Peter Tougaard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-9 and its receptor are predominantly involved in the pathogenesis of UC

(2014) Nancy Nalleweg et al.   GUT

Microbiota activation and regulation of innate and adaptive immunity

(2014) Katie L. Alexander et al.   IMMUNOLOGICAL REVIEWS

TNFSF15 is an independent predictor for the development of Crohn's disease-related complications in Koreans

(2014) Dong-Hoon Yang et al.   Journal of Crohns & Colitis

Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis

(2014) D Q Shih et al.   Mucosal Immunology

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

(2014) Katharina Gerlach et al.   NATURE IMMUNOLOGY

Inflammasomes and the microbiota—partners in the preservation of mucosal homeostasis

(2014) Maayan Levy et al.   Seminars in Immunopathology

Immunopathology of inflammatory bowel disease

(2014) Kori L Wallace   WORLD JOURNAL OF GASTROENTEROLOGY

Tolerogenic CX3CR1+B cells suppress food allergy-induced intestinal inflammation in mice

(2013) Z.-Q. Liu et al.   ALLERGY

Interferon-γ produced by tumor-infiltrating NK cells and CD4+ T cells downregulates TNFSF15 expression in vascular endothelial cells

(2013) Yi Lu et al.   ANGIOGENESIS

Innate and adaptive immunity in inflammatory bowel disease

(2013) Alessandra Geremia et al.   AUTOIMMUNITY REVIEWS

Defective Antibacterial Barrier in Inflammatory Bowel Disease

(2013) Thomas Klag et al.   DIGESTIVE DISEASES

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

(2013) Anja Fuchs et al.   IMMUNITY

Th9 cells: differentiation and disease

(2013) Mark H. Kaplan   IMMUNOLOGICAL REVIEWS

Induced and Natural Regulatory T Cells in the Development of Inflammatory Bowel Disease

(2013) Christopher G. Mayne et al.   INFLAMMATORY BOWEL DISEASES

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cloning, Expression, and Functional Characterization of TL1A-Ig

(2013) S. Q. Khan et al.   JOURNAL OF IMMUNOLOGY

Smad2/3 and IRF4 Play a Cooperative Role in IL-9-Producing T Cell Induction

(2013) T. Tamiya et al.   JOURNAL OF IMMUNOLOGY

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

TLR-induced PAI-2 expression suppresses IL-1  processing via increasing autophagy and NLRP3 degradation

(2013) S.-Y. Chuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions of NOD-Like Receptors in Human Diseases

(2013) Yifei Zhong et al.   Frontiers in Immunology

Proteases and the gut barrier

(2012) Paolo Biancheri et al.   CELL AND TISSUE RESEARCH

Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors

(2012) Christian Bauer et al.   DIGESTIVE DISEASES

Identification of Disease-Associated DNA Methylation in B Cells from Crohn’s Disease and Ulcerative Colitis Patients

(2012) Zhenwu Lin et al.   DIGESTIVE DISEASES AND SCIENCES

Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project

(2012) Isabelle Cleynen et al.   GUT

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

(2012) Margherita Coccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Human  -Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

(2012) H. Chu et al.   SCIENCE

B1a lymphocytes in the rectal mucosa of ulcerative colitis patients

(2012) Lino Polese   WORLD JOURNAL OF GASTROENTEROLOGY

The Prognostic Power of the NOD2 Genotype for Complicated Crohn's Disease: A Meta-Analysis

(2011) Jeremy Adler et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Constitutive TL1A Expression under Colitogenic Conditions Modulates the Severity and Location of Gut Mucosal Inflammation and Induces Fibrostenosis

(2011) Robert Barrett et al.   AMERICAN JOURNAL OF PATHOLOGY

ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation

(2011) Theo S. Plantinga et al.   Autophagy

The absence of B lymphocytes reduces the number and function of T-regulatory cells and enhances the anti-tumor response in a murine tumor model

(2011) Tamar Tadmor et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation

(2011) Trine Olsen et al.   CYTOKINE

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2

(2011) T. S. Plantinga et al.   GUT

It Takes Two to Tango

(2011) Angelina B. Bilate et al.   IMMUNITY

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

(2011) Dipica Haribhai et al.   IMMUNITY

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

(2011) Jessica M. Holmn Larsson et al.   INFLAMMATORY BOWEL DISEASES

New Pathogenic Paradigms in Inflammatory Bowel Disease

(2011) Antonio Di Sabatino et al.   INFLAMMATORY BOWEL DISEASES

STAT6-Dependent Regulation of Th9 Development

(2011) R. Goswami et al.   JOURNAL OF IMMUNOLOGY

Allergen-Specific Transforming Growth Factor-β-Producing CD19(+)CD5(+) Regulatory B-Cell (Br3) Responses in Human Late Eczematous Allergic Reactions to Cow's Milk

(2011) Jae Ho Lee et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis

(2011) David Q. Shih et al.   PLoS One

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

(2011) S. Normand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiotal influence on T cell subset development

(2011) Koji Atarashi et al.   SEMINARS IN IMMUNOLOGY

Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host–microbiota homeostasis

(2011) Takeshi Tanoue et al.   SEMINARS IN IMMUNOLOGY

KCNN4 Gene Variant Is Associated With Ileal Crohn's Disease in the Australian and New Zealand Population

(2010) Lisa A Simms et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction

(2010) G. Matteoli et al.   GUT

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

IL-23/IL-17 axis in IBD

(2010) Massimiliano Sarra et al.   INFLAMMATORY BOWEL DISEASES

Toll-like receptors in inflammatory bowel diseases: A decade later

(2010) Elke Cario   INFLAMMATORY BOWEL DISEASES

Genetic predictors of medically refractory ulcerative colitis

(2010) Talin Haritunians et al.   INFLAMMATORY BOWEL DISEASES

Genetic association between NLRP3 variants and Crohnʼs disease does not replicate in a large UK panel

(2010) Gregory J. Lewis et al.   INFLAMMATORY BOWEL DISEASES

Importance of disrupted intestinal barrier in inflammatory bowel diseases

(2010) Saʼad Y. Salim et al.   INFLAMMATORY BOWEL DISEASES

Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model

(2010) Sylvie Amu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice

(2010) Philippe Georgel et al.   MOLECULAR IMMUNOLOGY

Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia

(2010) V Y Taraban et al.   Mucosal Immunology

The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation

(2010) F Meylan et al.   Mucosal Immunology

Intestinal macrophages and response to microbial encroachment

(2010) P D Smith et al.   Mucosal Immunology

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

(2010) Hua-Chen Chang et al.   NATURE IMMUNOLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

(2010) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined Polymorphisms in Genes Encoding the Inflammasome Components NALP3 and CARD8 Confer Susceptibility to Crohn's Disease in Swedish Men

(2009) Ida Schoultz et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Regulatory Lymphocytes and Intestinal Inflammation

(2009) Ana Izcue et al.   Annual Review of Immunology

Developmental plasticity of Th17 and Treg cells

(2009) Yun Kyung Lee et al.   CURRENT OPINION IN IMMUNOLOGY

TLR8-mediated activation of human monocytes inhibits TL1A expression

(2009) Masayuki Saruta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential regulation of interleukin 17 and interferon   production in inflammatory bowel disease

(2009) L. Rovedatti et al.   GUT

Regulatory T Cells Reinforce Intestinal Homeostasis

(2009) Michael J. Barnes et al.   IMMUNITY

Mesenteric Lymph Nodes Confine Dendritic Cell-Mediated Dissemination of Salmonella enterica Serovar Typhimurium and Limit Systemic Disease in Mice

(2009) S. Voedisch et al.   INFECTION AND IMMUNITY

Toll-like receptors and their role in gastrointestinal disease

(2009) Adam G Testro et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation

(2009) Amit Awasthi et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-23 and Autoimmunity: New Insights into the Pathogenesis of Inflammatory Bowel Disease

(2008) Clara Abraham et al.   Annual Review of Medicine

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Diminution of Circulating CD4+CD25high T Cells in Naïve Crohn’s Disease

(2008) Patrick Chamouard et al.   DIGESTIVE DISEASES AND SCIENCES

Cytotoxic T-Lymphocyte-Associated Antigen 4 Antibody-Induced Colitis and Its Management with Infliximab

(2008) R. L. Johnston et al.   DIGESTIVE DISEASES AND SCIENCES

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY

TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation

(2008) Hidetoshi Takedatsu et al.   GASTROENTEROLOGY

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

The Biology of Intestinal Immunoglobulin A Responses

(2008) Andrea Cerutti et al.   IMMUNITY

Mucosal macrophages and the regulation of immune responses in the intestine

(2008) Andrew M. Platt et al.   IMMUNOLOGY LETTERS

TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

(2008) Bhanu P. Pappu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

(2008) Y. Onishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA