Autophagy in airway diseases: a new frontier in human asthma?

Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1

(2015) Behzad Yeganeh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sphingolipids as cell fate regulators in lung development and disease

(2015) Joyce Lee et al.   APOPTOSIS

IL13 activates autophagy to regulate secretion in airway epithelial cells

(2015) John D Dickinson et al.   Autophagy

Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis

(2015) Sandra Cabrera et al.   Autophagy

Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts

(2015) S Ghavami et al.   Cell Death & Disease

Instructive Roles of Extracellular Matrix on Autophagy

(2014) Thomas Neill et al.   AMERICAN JOURNAL OF PATHOLOGY

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation

(2014) Daniela De Stefano et al.   Autophagy

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

Airway mesenchymal cell death by mevalonate cascade inhibition: Integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins

(2014) Saeid Ghavami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lessons learned from mice and man: Mimicking human allergy through mouse models

(2014) Michelle T. Graham et al.   CLINICAL IMMUNOLOGY

Autophagy and Heart Disease: Implications for Cardiac Ischemia- Reperfusion Damage

(2014) S. Ghavami et al.   CURRENT MOLECULAR MEDICINE

Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

(2014) Benoit Pasquier et al.   JOURNAL OF MEDICINAL CHEMISTRY

mTOR and autophagy in regulation of acute lung injury: a review and perspective

(2014) Yue Hu et al.   MICROBES AND INFECTION

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics

(2013) Emanuele Marzetti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy in the immune system

(2013) Daniel J. Puleston et al.   IMMUNOLOGY

Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics

(2013) Akintunde Akinleye et al.   Journal of Hematology & Oncology

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Insufficient autophagy in idiopathic pulmonary fibrosis

(2012) Jun Araya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

More Muscle in Asthma, but Where Did It Come From?

(2012) Alastair Stewart   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

LC3 as a potential therapeutic target in hypoxia-induced pulmonary hypertension

(2012) Tim Lahm et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment

(2012) Irene Brana et al.   BMC Medicine

Into the matrix

(2012) Pitchumani Sivakumar et al.   CURRENT OPINION IN PULMONARY MEDICINE

Autophagy and role in asthma

(2012) Soma S.S.K. Jyothula et al.   CURRENT OPINION IN PULMONARY MEDICINE

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Rescue of Dysfunctional Autophagy Attenuates Hyperinflammatory Responses from Cystic Fibrosis Cells

(2012) M. L. Mayer et al.   JOURNAL OF IMMUNOLOGY

Functional Variant in the Autophagy-Related 5 Gene Promotor is Associated with Childhood Asthma

(2012) Lisa J. Martin et al.   PLoS One

Novel non-canonical TGF-β signaling networks: Emerging roles in airway smooth muscle phenotype and function

(2012) Behzad Yeganeh et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

l-Carnitine enhances extracellular matrix synthesis in human primary chondrocytes

(2012) Daniela Stoppoloni et al.   RHEUMATOLOGY INTERNATIONAL

Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation

(2012) Vojo Deretic et al.   TRENDS IN CELL BIOLOGY

Hyperoxia-Induced LC3B Interacts with the Fas Apoptotic Pathway in Epithelial Cell Death

(2011) Akihiko Tanaka et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting autophagy enhances BO-1051-induced apoptosis in human malignant glioma cells

(2011) Pei-Ming Chu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Editorial [Hot Topic: Phosphoinositide 3-Kinase Pathway Inhibitors: Pharmacology, Metabolism & Drug Development (Guest Editor: Marco Falasca)]

(2011) Marco Falasca   CURRENT MEDICINAL CHEMISTRY

Small-molecule inhibitors of the PI3K signaling network

(2011) Colleen R McNamara et al.   Future Medicinal Chemistry

Genetic and histologic evidence for autophagy in asthma pathogenesis

(2011) Audrey H. Poon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion

(2011) Caroline Bruns et al.   JOURNAL OF CELL BIOLOGY

Virus-triggered autophagy in viral hepatitis - possible novel strategies for drug development

(2011) S. M. Alavian et al.   JOURNAL OF VIRAL HEPATITIS

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Scraping fibrosis: Expressway to the core of fibrosis

(2011) Wajahat Z Mehal et al.   NATURE MEDICINE

Autophagic Protein LC3B Confers Resistance against Hypoxia-induced Pulmonary Hypertension

(2010) Seon-Jin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Mevalonate Cascade as a Target to Suppress Extracellular Matrix Synthesis by Human Airway Smooth Muscle

(2010) Dedmer Schaafsma et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Unconventional secretion of Acb1 is mediated by autophagosomes

(2010) Juan M. Duran et al.   JOURNAL OF CELL BIOLOGY

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Development of Phosphoinositide-3 Kinase Pathway Inhibitors for Advanced Cancer

(2010) James M. Cleary et al.   Current Oncology Reports

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of autophagy and proteasome degradation pathways in apoptosis of PC12 cells overexpressing human α-synuclein

(2009) Fang Yang et al.   NEUROSCIENCE LETTERS

mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex

(2009) E. Y. Chan   Science Signaling

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL