The Potential for Cancer Immunotherapy in Targeting Surgery-Induced Natural Killer Cell Dysfunction

IL-10+ NK and TGF-β+ NK cells play negative regulatory roles in HIV infection

(2018) Yongjun Jiang et al.   BMC INFECTIOUS DISEASES

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

(2018) Ye Li et al.   Cell Stem Cell

Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor–Mediated Natural Killer Cell Function

(2018) Andrew Stiff et al.   CLINICAL CANCER RESEARCH

Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult

(2018) Tyler J. Loftus et al.   CURRENT OPINION IN HEMATOLOGY

Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain

(2018) Austin Chou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of PDL1 signaling blockade on NK cell cytolytic activity towards ovarian cancer.

(2018) Jeremiah Oyer et al.   JOURNAL OF CLINICAL ONCOLOGY

Phosphodiesterase-5 inhibition reduces postoperative metastatic disease by targeting surgery-induced myeloid derived suppressor cell-dependent inhibition of Natural Killer cell cytotoxicity

(2018) Lee-Hwa Tai et al.   OncoImmunology

Natural Killer Cell IFNγ Secretion is Profoundly Suppressed Following Colorectal Cancer Surgery

(2018) Leonard Angka et al.   ANNALS OF SURGICAL ONCOLOGY

Surgical trauma contributes to progression of colon cancer by downregulating CXCL4 and recruiting MDSCs

(2018) Pingbo Xu et al.   EXPERIMENTAL CELL RESEARCH

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

(2018) Joy Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

The Cytotoxic Activity of Natural Killer Cells Is Suppressed by IL-10+ Regulatory T Cells During Acute Retroviral Infection

(2018) Elisabeth Littwitz-Salomon et al.   Frontiers in Immunology

Contribution of regulatory T cells to cancer: A review

(2018) Masoud Najafi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis

(2017) Rosa Molfetta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysfunctional Natural Killer Cells in the Aftermath of Cancer Surgery

(2017) Leonard Angka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer

(2017) Nicholas A. Taylor et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety and Activity of Varlilumab, a Novel and First-in-Class Agonist Anti-CD27 Antibody, in Patients With Advanced Solid Tumors

(2017) Howard A. Burris et al.   JOURNAL OF CLINICAL ONCOLOGY

Surgery-induced monocytic myeloid-derived suppressor cells expand regulatory T cells in lung cancer

(2017) Jun Wang et al.   Oncotarget

Generation of “Off-the-Shelf” Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells

(2017) Jieming Zeng et al.   Stem Cell Reports

Shaping of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation

(2017) Markus Granzin et al.   Frontiers in Immunology

Developmental and Functional Control of Natural Killer Cells by Cytokines

(2017) Yang Wu et al.   Frontiers in Immunology

Natural Killer Cell-Based Cancer Immunotherapies: From Immune Evasion to Promising Targeted Cellular Therapies

(2017) Erhard Hofer et al.   Frontiers in Immunology

The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy

(2017) Sourav Paul et al.   Frontiers in Immunology

Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination

(2017) Annkristin Heine et al.   OncoImmunology

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

(2017) Susanne M. Steggerda et al.   Journal for ImmunoTherapy of Cancer

MDSCs are induced after experimental blunt chest trauma and subsequently alter antigen-specific T cell responses

(2017) Yvonne Hüsecken et al.   Scientific Reports

Adaptive NK Cells with Low TIGIT Expression Are Inherently Resistant to Myeloid-Derived Suppressor Cells

(2016) Dhifaf Sarhan et al.   CANCER RESEARCH

Rationale for anti-CD137 cancer immunotherapy

(2016) Amani Makkouk et al.   EUROPEAN JOURNAL OF CANCER

Hepatitis C Virus–Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1

(2016) Celeste C. Goh et al.   JOURNAL OF IMMUNOLOGY

Propranolol Attenuates Surgical Stress–Induced Elevation of the Regulatory T Cell Response in Patients Undergoing Radical Mastectomy

(2016) Lei Zhou et al.   JOURNAL OF IMMUNOLOGY

Inhibition of β2-adrenergic receptor reduces triple-negative breast cancer brain metastases: The potential benefit of perioperative β-blockade

(2016) CECILIA CHOY et al.   ONCOLOGY REPORTS

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

28 day post-operative persisted hypercoagulability after surgery for benign diseases: a prospective cohort study

(2016) Jan Ulrych et al.   BMC Surgery

Natural Killer Cells for Immunotherapy – Advantages of the NK-92 Cell Line over Blood NK Cells

(2016) Hans Klingemann et al.   Frontiers in Immunology

P-Selectin-Mediated Adhesion between Platelets and Tumor Cells Promotes Intestinal Tumorigenesis in ApcMin/+ Mice

(2015) Cuiling Qi et al.   International Journal of Biological Sciences

Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer

(2015) Naoyuki Sakamoto et al.   Journal of Translational Medicine

Exploiting the critical perioperative period to improve long-term cancer outcomes

(2015) Maya Horowitz et al.   Nature Reviews Clinical Oncology

Invasive Surgery Impairs the Regulatory Function of Human CD56bright Natural Killer Cells in Response to Staphylococcus aureus. Suppression of Interferon-γ Synthesis

(2015) Renate Reinhardt et al.   PLoS One

Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection

(2015) Elisabeth Littwitz-Salomon et al.   Retrovirology

A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection

(2015) W. Deng et al.   SCIENCE

Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients

(2015) Michaela Semeraro et al.   Science Translational Medicine

Inhibition of Natural Killer Cell Cytotoxicity by Interleukin-6: Implications for the Pathogenesis of Macrophage Activation Syndrome

(2015) Loredana Cifaldi et al.   Arthritis & Rheumatology

Natural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for Cancer Immunotherapy

(2015) Cariad Chester et al.   Frontiers in Immunology

Natural Killer Cell-Based Therapies Targeting Cancer: Possible Strategies to Gain and Sustain Anti-Tumor Activity

(2015) Carin I. M. Dahlberg et al.   Frontiers in Immunology

Failure recovery of circulating NKG2D+CD56dimNK cells in HBV-associated hepatocellular carcinoma after hepatectomy predicts early recurrence

(2015) Jian Gao et al.   OncoImmunology

Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1

(2015) Vanessa Kruse et al.   PLoS One

Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

Inhibition of Tumor-Derived Prostaglandin-E2 Blocks the Induction of Myeloid-Derived Suppressor Cells and Recovers Natural Killer Cell Activity

(2014) Y. Mao et al.   CLINICAL CANCER RESEARCH

Safety, efficacy, and pharmacokinetics/pharmacodynamics of daclizumab (anti-CD25) in patients with adult T-cell leukemia/lymphoma

(2014) Jonathan L. Berkowitz et al.   CLINICAL IMMUNOLOGY

An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression

(2014) Young-Ju Kang et al.   HUMAN REPRODUCTION

Targeting CD137 enhances the efficacy of cetuximab

(2014) Holbrook E. Kohrt et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF- 1

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

In Vivo Maintenance of Human Regulatory T Cells during CD25 Blockade

(2014) David J. Huss et al.   JOURNAL OF IMMUNOLOGY

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

(2014) Antoine Marçais et al.   NATURE IMMUNOLOGY

An Increased Abundance of Tumor-Infiltrating Regulatory T Cells Is Correlated with the Progression and Prognosis of Pancreatic Ductal Adenocarcinoma

(2014) Yichen Tang et al.   PLoS One

Natural Killer Cells for Cancer Immunotherapy: Pluripotent Stem Cells-Derived NK Cells as an Immunotherapeutic Perspective

(2014) Cristina Eguizabal et al.   Frontiers in Immunology

Reversal of natural killer cell exhaustion by TIM-3 blockade

(2014) Anne Gallois et al.   OncoImmunology

In vivo suppression of NK cell cytotoxicity by stress and surgery: Glucocorticoids have a minor role compared to catecholamines and prostaglandins

(2013) Ella Rosenne et al.   BRAIN BEHAVIOR AND IMMUNITY

Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

(2013) Y Ino et al.   BRITISH JOURNAL OF CANCER

Interaction between natural killer cells and regulatory T cells: perspectives for immunotherapy

(2013) Isabela Pedroza-Pacheco et al.   Cellular & Molecular Immunology

Perioperative Influenza Vaccination Reduces Postoperative Metastatic Disease by Reversing Surgery-Induced Dysfunction in Natural Killer Cells

(2013) L.-H. Tai et al.   CLINICAL CANCER RESEARCH

Changes of CD4+CD25+FOXP3+ and CD8+CD28− regulatory T cells in non-small cell lung cancer patients undergoing surgery

(2013) Cheng Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Agonist Anti-Human CD27 Monoclonal Antibody Induces T Cell Activation and Tumor Immunity in Human CD27-Transgenic Mice

(2013) L.-Z. He et al.   JOURNAL OF IMMUNOLOGY

Local Arginase 1 Activity Is Required for Cutaneous Wound Healing

(2013) Laura Campbell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Recovery of Immunological Homeostasis Positively Correlates Both with Early Stages of Right-Colorectal Cancer and Laparoscopic Surgery

(2013) Mario Ferri et al.   PLoS One

Regulatory T cells in the blood: a new marker of surgical stress

(2013) Yu Saito et al.   SURGERY TODAY

Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy

(2013) David A. Knorr et al.   Stem Cells Translational Medicine

Consequences of the crosstalk between monocytes/macrophages and natural killer cells

(2013) Tatiana Michel et al.   Frontiers in Immunology

Regulation of Adaptive Immunity; The Role of Interleukin-10

(2013) T. H. Sky Ng et al.   Frontiers in Immunology

The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity

(2013) Joanna Baginska et al.   Frontiers in Immunology

A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis

(2013) Xinrong Ma et al.   OncoImmunology

Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection

(2013) J. Wesley Alexander et al.   Advances in Wound Care

Surgical Stress Promotes the Development of Cancer Metastases by a Coagulation-Dependent Mechanism Involving Natural Killer Cells in a Murine Model

(2012) Rashmi Seth et al.   ANNALS OF SURGERY

PGE2 suppresses NK activity in vivo directly and through adrenal hormones: Effects that cannot be reflected by ex vivo assessment of NK cytotoxicity

(2012) G. Meron et al.   BRAIN BEHAVIOR AND IMMUNITY

Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells

(2012) L.-H. Tai et al.   CANCER RESEARCH

Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells

(2012) M. Terme et al.   CANCER RESEARCH

Cutting Edge: A Novel Mechanism Bridging Innate and Adaptive Immunity: IL-12 Induction of CD25 To Form High-Affinity IL-2 Receptors on NK Cells

(2012) S.-H. Lee et al.   JOURNAL OF IMMUNOLOGY

Comparison of Surgical Stress in Patients Undergoing Open Versus Laparoscopic Radical Prostatectomy by Measuring Perioperative Serum Cytokine Levels

(2012) Shintaro Narita et al.   Journal of Laparoendoscopic & Advanced Surgical Techniques

Daclizumab Therapy for Multiple Sclerosis

(2012) Bibiana Bielekova   Neurotherapeutics

Surgical treatment of liver metastases of gastric cancer: state of the art

(2012) Fabrizio Romano et al.   World Journal of Surgical Oncology

TGF-β1 Down-Regulation of NKG2D/DAP10 and 2B4/SAP Expression on Human NK Cells Contributes to HBV Persistence

(2012) Cheng Sun et al.   PLoS Pathogens

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Postoperative changes in procoagulant factors after major surgery

(2011) Susanne Lison et al.   BLOOD COAGULATION & FIBRINOLYSIS

Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4

(2011) Dawn Holt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Impact of Anastomotic Leak and Intra-Abdominal Abscess on Cancer-Related Outcomes After Resection for Colorectal Cancer

(2011) Joshua M. Eberhardt et al.   DISEASES OF THE COLON & RECTUM

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

TGF-  downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients

(2011) C. A. Crane et al.   NEURO-ONCOLOGY

Clinical-Grade Generation of Active NK Cells from Cord Blood Hematopoietic Progenitor Cells for Immunotherapy Using a Closed-System Culture Process

(2011) Jan Spanholtz et al.   PLoS One

CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies

(2010) H. E. Kohrt et al.   BLOOD

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody

(2010) D. M. Benson et al.   BLOOD

Selective Depletion of Foxp3+ Regulatory T Cells Improves Effective Therapeutic Vaccination against Established Melanoma

(2010) K. Klages et al.   CANCER RESEARCH

Peri-operative modulation of cellular immunity in patients with colorectal cancer

(2010) P.H. NICHOLS et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunosupression and Infection After Major Surgery: A Nutritional Deficiency

(2010) Xinmei Zhu et al.   CRITICAL CARE CLINICS

Good manufacturing practice-compliant cell sorting and large-scale expansion of single KIR-positive alloreactive human natural killer cells for multiple infusions to leukemia patients

(2010) Uwe Siegler et al.   CYTOTHERAPY

IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function

(2010) Moshe Elkabets et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Multiple Mechanisms Downstream of TLR-4 Stimulation Allow Expression of NKG2D Ligands To Facilitate Macrophage/NK Cell Crosstalk

(2010) P. Eissmann et al.   JOURNAL OF IMMUNOLOGY

Immunomodulatory Effects of in vitroStress Hormones on FoxP3, Th1/Th2 Cytokine and Costimulatory Molecule mRNA Expression in Human Peripheral Blood Mononuclear Cells

(2010) Lianbin Xiang et al.   NEUROIMMUNOMODULATION

The Perioperative Period is an Underutilized Window of Therapeutic Opportunity in Patients With Colorectal Cancer

(2009) Gerben J. van der Bij et al.   ANNALS OF SURGERY

Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity

(2009) P. S. Woll et al.   BLOOD

Regulatory Natural Killer Cells: New Players in the IL-10 Anti-Inflammatory Response

(2009) Eric Vivier et al.   Cell Host & Microbe

Systemic but Not Local Infections Elicit Immunosuppressive IL-10 Production by Natural Killer Cells

(2009) Georgia Perona-Wright et al.   Cell Host & Microbe

Clinical-grade ex vivo-expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells

(2009) Maria Berg et al.   CYTOTHERAPY

Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor

(2009) Bastian Hoechst et al.   HEPATOLOGY

Regulation of NK Cell Function by Human Granulocyte Arginase

(2009) J. Oberlies et al.   JOURNAL OF IMMUNOLOGY

The effects of surgery on tumor growth: a century of investigations

(2008) R. Demicheli et al.   ANNALS OF ONCOLOGY

Perioperative Use of β-blockers and COX-2 Inhibitors May Improve Immune Competence and Reduce the Risk of Tumor Metastasis

(2008) Marganit Benish et al.   ANNALS OF SURGICAL ONCOLOGY

Selective Induction of Expression of a Ligand for the NKG2D Receptor by Proteasome Inhibitors

(2008) M. Vales-Gomez et al.   CANCER RESEARCH

Effective Depletion of Regulatory T Cells Allows the Recruitment of Mesothelin-Specific CD8+T Cells to the Antitumor Immune Response Against a Mesothelin-Expressing Mouse Pancreatic Adenocarcinoma

(2008) Ihid C. Leao et al.   CTS-Clinical and Translational Science

Potential Role of NK Cells in the Induction of Immune Responses: Implications for NK Cell–Based Immunotherapy for Cancers and Viral Infections

(2008) Hiroshi Terunuma et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

NK cells and cancer immunosurveillance

(2008) I Waldhauer et al.   ONCOGENE