Review
Biochemistry & Molecular Biology
Tyler C. Moore, Kim J. Hasenkrug
Summary: B lymphocytes play important roles during viral infections by producing antibodies, acting as antigen-presenting cells, regulating immune responses, and inducing Tregs. In the Friend virus model, Tregs inhibit effector CD8+ T-cell responses and contribute to virus persistence. Research focuses on the interactions between B cells and Tregs during FV infection.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Immunology
Jingnan Liao, Yuan Li, Xiaofeng Li, Xian Su, Jing Peng, Na Xiao, Xiangxiu Fan, Huijun Chen, Guangxiu Lu, Ge Lin, Lamei Cheng, Fei Gong
Summary: The study found that pre-pregnancy blood Treg levels were significantly lower in URPL patients than in controls, and that Treg levels predicted subsequent miscarriages. There were no significant differences among other blood cell types between the two groups.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Joao Canto-Gomes, Carolina S. Silva, Rita Rb-Silva, Daniela Boleixa, Ana Martins da Silva, Remi Cheynier, Patricio Costa, Ines Gonzalez-Suarez, Margarida Correia-Neves, Joao J. Cerqueira, Claudia Nobrega
Summary: The aim of this study is to assess the peripheral immune system of newly diagnosed patients with relapsing remitting multiple sclerosis (RRMS) and identify immune features associated with clinical onset.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Douglas Grant Osborne, Joanne Domenico, Mayumi Fujita
Summary: In this study, we demonstrated that ectopic expression of IL-37 in non-Treg CD4+ T cells can induce a Treg phenotype and function. The stable human Treg-like cell line created in this study offers convenience for in vitro studies of human Treg cells and provides new insights into Treg cell biology and function.
Article
Oncology
Xiao-Dong Mao, Su-Zhu Chen, Su-Qing Shen, Kang-Sheng Liu
Summary: The impact of the immune response on the therapeutic efficacy of neoadjuvant chemotherapy for breast cancer is unclear. This study investigated the correlation patterns of immune cell subsets with the progression of breast cancer during neoadjuvant chemotherapy. The levels of T lymphocyte subsets were influenced by neoadjuvant chemotherapy, and the immune response status varied in different clinical stages.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Kie Mizumaki, Motoki Horii, Miyu Kano, Akito Komuro, Takashi Matsushita
Summary: This study found that increased regulatory B cells in mice can suppress IL-23-mediated psoriasis-like inflammation by expanding regulatory T cells and inhibiting Th17 cell differentiation, making them a potential strategy for treating psoriasis.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dao X. Nguyen, Helen M. Baldwin, Amara N. Ezeonyeji, Mohammed Rohan Butt, Michael R. Ehrenstein
Summary: The study revealed that patients with PsA have an increased Th17:Treg ratio, which can be reversed by anti-TNF therapy. Treg from patients treated with different therapies showed contrasting effects on regulating effector T-cell migration, with TNF blockade boosting Treg suppression of migration.
Article
Multidisciplinary Sciences
Pawan K. Gupta, Jennifer B. Allocco, Jane M. Fraipont, Michelle L. McKeague, Peter Wang, Michael S. Andrade, Christine McIntosh, Luqiu Chen, Ying Wang, Yan Li, Jorge Andrade, Jose R. Conejo-Garcia, Anita S. Chong, Maria-Luisa Alegre
Summary: This study investigates the susceptibility of Tconvs to Treg suppression during tolerance induction in transplantation. The findings suggest that transplantation tolerance is associated with an increased sensitivity of alloreactive Tconvs to Treg suppression, which is regulated by the expression of the transcription factor Satb1. Targeting Satb1 could potentially be a strategy to improve transplant outcomes by modulating Treg-sparing immunosuppressive therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Daniil Shevyrev, Valeriy Tereshchenko, Elena Blinova, Nadezda Knauer, Ekaterina Pashkina, Alexey Sizikov, Vladimir Kozlov
Summary: The study revealed that the proliferation of Treg cells in patients with rheumatoid arthritis under HP cytokine stimulation is lower compared to healthy individuals, and the suppressive activity decreases, which may lead to the proliferation of self-reactive T cell clones.
Review
Immunology
Payal Grover, Peeyush N. Goel, Mark I. Greene
Summary: T regulatory cells employ various immunosuppressive mechanisms to limit immune responses, including secretion of cytokines, cell cytolysis, metabolic perturbation, guiding antigen-presenting cell function, etc.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Murilo Delgobo, Emil Weiss, DiyaaElDin, Ashour Leon Richter, Lisa Popiolkowski, Panagiota Arampatzi, Verena Stangl, Paula Arias-Loza, Encarnita Mariotti-Ferrandiz, Peter P. Rainer, Antoine-Emmanuel Saliba, Burkhard Ludewig, Ulrich Hofmann, Stefan Frantz, Gustavo Campos Ramos
Summary: In this study, the researchers investigated how antigen-specific T-helper cells differentiate in the myocardial environment. They used a transgenic T cell receptor model and single-cell transcriptomics to study the cells in the murine infarcted myocardium. The results showed that these cells acquired a regulatory phenotype and influenced tissue repair.
CIRCULATION RESEARCH
(2023)
Review
Cell Biology
Sabrina Ceeraz, Charlotte R. Thompson, Richard Beatson, Ernest H. Choy
Summary: T regulatory cell therapy offers a new approach for treating autoimmune diseases and transplantation. CD8(+) Treg cells, particularly the CD8(+)CD28(-) subset, have been shown to be effective in preclinical models, although their impaired functionality in disease limits their effectiveness in immunosuppression. The review focuses on harnessing CD8(+) Treg cell therapy in clinical settings to aid current treatments for autoimmune and inflammatory conditions.
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Cecilia Vallet, Dennis Aschmann, Christine Beuck, Matthias Killa, Annika Meiners, Marcel Mertel, Martin Ehlers, Peter Bayer, Carsten Schmuck, Michael Giese, Shirley K. Knauer
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Immunology
Ariane Zutz, Christian Schoelz, Stephanie Schneider, Virginia Pierini, Maximilian Muenchhoff, Kathrin Sutter, Georg Wittmann, Ulf Dittmer, Rika Draenert, Johannes R. Bogner, Oliver T. Fackler, Oliver T. Keppler
JOURNAL OF INNATE IMMUNITY
(2020)
Review
Virology
Jia Liu, Xin Zheng, Qiaoxia Tong, Wei Li, Baoju Wang, Kathrin Sutter, Mirko Trilling, Mengji Lu, Ulf Dittmer, Dongliang Yang
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Multidisciplinary Sciences
Julia Ickler, Sandra Francois, Marek Widera, Mario L. Santiago, Ulf Dittmer, Kathrin Sutter
Article
Gastroenterology & Hepatology
Jieliang Chen, Yaming Li, Fritz Lai, Yang Wang, Kathrin Sutter, Ulf Dittmer, Jianyu Ye, Wenjing Zai, Min Liu, Fang Shen, Min Wu, Kongying Hu, Baocun Li, Mengji Lu, Xiaonan Zhang, Jiming Zhang, Jianhua Li, Qingfeng Chen, Zhenghong Yuan
Summary: The study identified IFN-alpha 14 as the most effective subtype in suppressing HBV replication, with significantly lower concentration values compared to conventional IFN-alpha 2. IFN-alpha 14 triggered a strong antiviral response through IFN-alpha and IFN-gamma signaling crosstalk, revealing mechanisms for potent HBV suppression. The findings deepen the understanding of the diverse activities of IFN-alpha subtypes and the synergistic effects of IFN-alpha and IFN-gamma signaling, potentially leading to improved HBV therapy strategies.
Article
Microbiology
Jaana Westmeier, Krystallenia Paniskaki, Zehra Karakoese, Tanja Werner, Kathrin Sutter, Sebastian Dolff, Marvin Overbeck, Andreas Limmer, Jia Liu, Xin Zheng, Thorsten Brenner, Marc M. Berger, Oliver Witzke, Mirko Trilling, Mengji Lu, Dongliang Yang, Nina Babel, Timm Westhoff, Ulf Dittmer, Gennadiy Zelinskyy
Article
Microbiology
Kejun Guo, Guannan Shen, Jon Kibbie, Tania Gonzalez, Stephanie M. Dillon, Harry A. Smith, Emily H. Cooper, Kerry Lavender, Kim J. Hasenkrug, Kathrin Sutter, Ulf Dittmer, Miranda Kroehl, Katerina Kechris, Cara C. Wilson, Mario L. Santiago
Review
Virology
Shichuan Wang, Mirko Trilling, Kathrin Sutter, Ulf Dittmer, Mengji Lu, Xin Zheng, Dongliang Yang, Jia Liu
Article
Medicine, General & Internal
Shue Xiong, Dan Zhu, Boyun Liang, Mingyue Li, Wen Pan, Junyi He, Hua Wang, Kathrin Sutter, Ulf Dittmer, Mengji Lu, Di Liu, Dongliang Yang, Jia Liu, Xin Zheng
Summary: The desirable endpoint of treatment against chronic hepatitis B virus infection is to achieve a functional cure, characterized by HBsAg loss with or without anti-HBs seroconversion. This study found that cHBV patients with sAg-L display distinct CD4(+) and CD8(+) T cell phenotype fingerprints compared to sAg-R patients, with upregulated HLA-DR expression and potent HBcAg-specific CD8(+) T cell response. The onset of HBsAg decrease and subsequent loss in cHBV patients on treatment is associated with significant alterations of both CD4(+) and CD8(+) T cell phenotypes, which may serve as predictive factors for sAg-L.
Article
Chemistry, Multidisciplinary
Thies Dirksmeyer, Paul Stahl, Cecilia Vallet, Shirley Knauer, Michael Giese, Carsten Schmuck, Christoph Hirschhaeuser
Summary: This study reported a transfection vector that can home in on tumors by combining biotin, which mediates cell selectivity, with a DNA-binding motif via a hydrophilic linker. It showed a preference for the BR-positive cell lines over the BR-negative controls.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Editorial Material
Chemistry, Multidisciplinary
Thies Dirksmeyer, Paul Stahl, Cecilia Vallet, Shirley Knauer, Michael Giese, Carsten Schmuck, Christoph Hirschhaeuser
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Nazli Aldemir, Cecilia Vallet, Shirley K. Knauer, Carsten Schmuck, Christoph Hirschhaeuser
Summary: A transfection vector based on a peptide dendrimer has been developed and its abilities for DNA binding and transport have been investigated. By attaching a fluorophore to the vector system, several steps in the transfection process could be monitored directly. The labeled vector condensed DNA into tightly packed aggregates able to enter eukaryotic cells, and co-localization experiments revealed the uptake pathway and subsequent fate of the ligand/plasmid complex.
Article
Immunology
Aline da Rocha Matos, Katharina Wunderlich, Sebastian Schloer, Klaus Schughart, Robert Geffers, Martine Seders, Marlous de Witt, Anmari Christersson, Rainer Wiewrodt, Karsten Wiebe, Peter Barth, Andreas Hocke, Stefan Hippenstiel, Katja Hoenzke, Ulf Dittmer, Kathrin Sutter, Ursula Rescher, Svetlana Rodionycheva, Nicoletta Matera, Stephan Ludwig, Linda Brunotte
EMERGING MICROBES & INFECTIONS
(2019)
Review
Microbiology
Ulf Dittmer, Kathrin Sutter, George Kassiotis, Gennadiy Zelinskyy, Zoltan Banki, Heribert Stoiber, Mario L. Santiago, Kim J. Hasenkrug
FEMS MICROBIOLOGY REVIEWS
(2019)
Article
Hematology
Cornelia Gujer, Anita Murer, Anne Mueller, Danusia Vanoaica, Kathrin Sutter, Emilie Jacque, Nathalie Fournier, Jens Kalchschmidt, Andrea Zbinden, Riccarda Capaul, Andrzej Dzionek, Philippe Mondon, Ulf Dittmer, Christian Muenz