Phosphodiesterase-5 inhibition reduces postoperative metastatic disease by targeting surgery-induced myeloid derived suppressor cell-dependent inhibition of Natural Killer cell cytotoxicity

The influence of myeloid-derived suppressor cells on angiogenesis and tumor growth after cancer surgery

(2016) Jun Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Tadalafil Augments Tumor Specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma

(2015) J. A. Califano et al.   CLINICAL CANCER RESEARCH

Tadalafil Reduces Myeloid-Derived Suppressor Cells and Regulatory T Cells and Promotes Tumor Immunity in Patients with Head and Neck Squamous Cell Carcinoma

(2014) D. T. Weed et al.   CLINICAL CANCER RESEARCH

Inhibition of Tumor-Derived Prostaglandin-E2 Blocks the Induction of Myeloid-Derived Suppressor Cells and Recovers Natural Killer Cell Activity

(2014) Y. Mao et al.   CLINICAL CANCER RESEARCH

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF- 1

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

The Central Role of Arginine Catabolism in T-Cell Dysfunction and Increased Susceptibility to Infection After Physical Injury

(2013) Xinmei Zhu et al.   ANNALS OF SURGERY

Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination

(2013) Lee-Hwa Tai et al.   OncoImmunology

Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells

(2012) L.-H. Tai et al.   CANCER RESEARCH

PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter

(2012) Jun-Jiang Chen et al.   CANCER SCIENCE

Myeloid-Derived Suppressor Cells Regulate Natural Killer Cell Response to Adenovirus-Mediated Gene Transfer

(2012) J. Zhu et al.   JOURNAL OF VIROLOGY

Improving Postoperative Immune Status and Resistance to Cancer Metastasis

(2011) Yael Goldfarb et al.   ANNALS OF SURGERY

Unknown

(2011) Alex Cuenca et al.   MOLECULAR MEDICINE

The Phosphodiesterase-5 Inhibitor Vardenafil Is a Potent Inhibitor of ABCB1/P-Glycoprotein Transporter

(2011) Pei-Rong Ding et al.   PLoS One

Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells

(2010) Xu Di et al.   BREAST CANCER RESEARCH AND TREATMENT

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

(2010) Suzanne Ostrand-Rosenberg   CANCER IMMUNOLOGY IMMUNOTHERAPY

Peri-operative modulation of cellular immunity in patients with colorectal cancer

(2010) P.H. NICHOLS et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Effect of Ly49 Haplotype Variance on NK Cell Function and Education

(2010) R. Patel et al.   JOURNAL OF IMMUNOLOGY

Improving Survival Rates in Two Models of Spontaneous Postoperative Metastasis in Mice by Combined Administration of a β-Adrenergic Antagonist and a Cyclooxygenase-2 Inhibitor

(2010) Ariella Glasner et al.   JOURNAL OF IMMUNOLOGY

Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction

(2010) A. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NK Cell Function by Human Granulocyte Arginase

(2009) J. Oberlies et al.   JOURNAL OF IMMUNOLOGY

Perioperative Use of β-blockers and COX-2 Inhibitors May Improve Immune Competence and Reduce the Risk of Tumor Metastasis

(2008) Marganit Benish et al.   ANNALS OF SURGICAL ONCOLOGY