Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4

PGE2 inhibits natural killer and γδ T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling

(2010) Ludovic Martinet et al.   BIOCHEMICAL PHARMACOLOGY

Prostaglandin E Receptor EP1 Suppresses Breast Cancer Metastasis and Is Linked to Survival Differences and Cancer Disparities

(2010) Xinrong Ma et al.   MOLECULAR CANCER RESEARCH

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclic AMP

(2008) Carlos H. Serezani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function

(2008) Namita Kundu et al.   BREAST CANCER RESEARCH AND TREATMENT

Prostaglandin E2 stimulates Fas ligand expression via the EP1 receptor in colon cancer cells

(2008) G O'Callaghan et al.   BRITISH JOURNAL OF CANCER

Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP–PKA signaling and immunosuppression

(2008) Yunyun Su et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

In vitro pharmacological characterization of CJ-042794, a novel, potent, and selective prostaglandin EP4 receptor antagonist

(2007) Akio Murase et al.   LIFE SCIENCES