Regulation of Apoptosis during Flavivirus Infection

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

(2017) Avi Ashkenazi et al.   NATURE REVIEWS DRUG DISCOVERY

Suppressive effect of dengue virus envelope protein domain III on megakaryopoiesis

(2017) Guan-Ling Lin et al.   Virulence

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism

(2016) M. A. Anderson et al.   BLOOD

Targeting BCL2 With BH3 Mimetics: Basic Science and Clinical Application of Venetoclax in Chronic Lymphocytic Leukemia and Related B Cell Malignancies

(2016) AW Roberts et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

(2016) Andrew W. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

Japanese encephalitis virus induces apoptosis by the IRE1/JNK pathway of ER stress response in BHK-21 cells

(2015) Mingjie Huang et al.   ARCHIVES OF VIROLOGY

Profiling of Virus-Encoded MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma and Their Roles in Gastric Carcinogenesis

(2015) Aya Shinozaki-Ushiku et al.   JOURNAL OF VIROLOGY

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

(2015) Joel D. Leverson et al.   Science Translational Medicine

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Repression of the Proapoptotic Cellular BIK/NBK Gene by Epstein-Barr Virus Antagonizes Transforming Growth Factor  1-Induced B-Cell Apoptosis

(2014) E. M. Campion et al.   JOURNAL OF VIROLOGY

Coordinated regulation of autophagy and apoptosis determines endothelial cell fate during Dengue virus type 2 infection

(2014) Junqi Huang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cellular Oxidative Stress Response Controls the Antiviral and Apoptotic Programs in Dengue Virus-Infected Dendritic Cells

(2014) David Olagnier et al.   PLoS Pathogens

Regulated IRE1-dependent decay pathway is activated during Japanese encephalitis virus-induced unfolded protein response and benefits viral replication

(2013) S. Bhattacharyya et al.   JOURNAL OF GENERAL VIROLOGY

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

West Nile virus NS2A protein facilitates virus-induced apoptosis independently of interferon response

(2012) E. B. Melian et al.   JOURNAL OF GENERAL VIROLOGY

Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins

(2012) T. Okamoto et al.   JOURNAL OF VIROLOGY

ATF6 Signaling Is Required for Efficient West Nile Virus Replication by Promoting Cell Survival and Inhibition of Innate Immune Responses

(2012) R. L. Ambrose et al.   JOURNAL OF VIROLOGY

The West Nile Virus Capsid Protein Blocks Apoptosis through a Phosphatidylinositol 3-Kinase-Dependent Mechanism

(2012) M. D. Urbanowski et al.   JOURNAL OF VIROLOGY

CD8+ T Cells Use TRAIL To Restrict West Nile Virus Pathogenesis by Controlling Infection in Neurons

(2012) B. Shrestha et al.   JOURNAL OF VIROLOGY

Induction of the Cellular MicroRNA, Hs_154, by West Nile Virus Contributes to Virus-Mediated Apoptosis through Repression of Antiapoptotic Factors

(2012) J. L. Smith et al.   JOURNAL OF VIROLOGY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dengue Virus Modulates the Unfolded Protein Response in a Time-dependent Manner

(2011) José Peña et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dengue Virus Type 3 Isolated from a Fatal Case with Visceral Complications Induces Enhanced Proinflammatory Responses and Apoptosis of Human Dendritic Cells

(2011) G. F. Silveira et al.   JOURNAL OF VIROLOGY

Latent Epstein-Barr Virus Can Inhibit Apoptosis in B Cells by Blocking the Induction of NOXA Expression

(2011) Jade Yee et al.   PLoS One

West Nile virus capsid protein interaction with importin and HDM2 protein is regulated by protein kinase C-mediated phosphorylation

(2010) Raghavan Bhuvanakantham et al.   MICROBES AND INFECTION

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A clinical isolate of dengue virus and its proteins induce apoptosis in HMEC-1 cells: a possible implication in pathogenesis

(2009) Melina Vásquez Ochoa et al.   ARCHIVES OF VIROLOGY

Pathogenesis of Flavivirus Infections: Using and Abusing the Host Cell

(2009) Maria-Dolores Fernandez-Garcia et al.   Cell Host & Microbe

Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells

(2009) Tsuey-Ching Yang et al.   VIRUS RESEARCH

Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis

(2009) Janjuree Netsawang et al.   VIRUS RESEARCH

An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival

(2008) Elizabeth Yee-Wai Choy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogenic flaviviruses

(2008) EA Gould et al.   LANCET

Induction of p53-dependent and mitochondria-mediated cell death pathway by dengue virus infection of human and animal cells

(2008) A NASIRUDEEN et al.   MICROBES AND INFECTION

Regulation of TNFR1 and CD95 signalling by receptor compartmentalization

(2008) Stefan Schütze et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY