The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products

(2013) Hartmut Jaeschke et al.   FOOD AND CHEMICAL TOXICOLOGY

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity

(2013) Dotan Uzi et al.   JOURNAL OF HEPATOLOGY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Xenobiotic Perturbation of ER Stress and the Unfolded Protein Response

(2013) Marc A. Lafleur et al.   TOXICOLOGIC PATHOLOGY

A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-α

(2013) Giulia Benedetti et al.   TOXICOLOGY IN VITRO

Hepatomas with activating Ctnnb1 mutations in ‘ Ctnnb1 -deficient’ livers: a tricky aspect of a conditional knockout mouse model

(2011) Shigeki Sekine et al.   CARCINOGENESIS

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

(2011) Hartmut Jaeschke et al.   LIVER INTERNATIONAL

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Crosstalk Between Endoplasmic Reticulum Stress and Mitochondrial Pathway Mediates Cadmium-Induced Germ Cell Apoptosis in Testes

(2011) Yan-Li Ji et al.   TOXICOLOGICAL SCIENCES

Bupropion, an atypical antidepressant, induces endoplasmic reticulum stress and caspase-dependent cytotoxicity in SH-SY5Y cells

(2011) Eun-Hee Jang et al.   TOXICOLOGY

Highly efficient gene transfer into hepatocyte-like HepaRG cells: New means for drug metabolism and toxicity studies

(2010) Veronique Laurent et al.   Biotechnology Journal

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes

(2010) Sebastian Zellmer et al.   HEPATOLOGY

Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout mice

(2010) Norio Horiguchi et al.   HEPATOLOGY

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

FXR Regulates Liver Repair after CCl4-Induced Toxic Injury

(2010) Zhipeng Meng et al.   MOLECULAR ENDOCRINOLOGY

Expander: from expression microarrays to networks and functions

(2010) Igor Ulitsky et al.   Nature Protocols

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

(2010) S. Hoehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

(2009) Edward Thorp et al.   Cell Metabolism

Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β-induced apoptosis

(2009) Patricio Godoy et al.   HEPATOLOGY

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION