Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases
Authors
Keywords
Adult onset neuronal ceroid lipofuscinosis, Aging, Alzheimer’s disease, Amyotrophic lateral sclerosis, Caenorhabditis elegans, Compound screening, Frontotemporal dementia, Huntington’s disease, Neurodegeneration, Parkinson’s disease
Journal
Chemistry Central Journal
Volume 9, Issue 1, Pages -
Publisher
Springer Nature
Online
2015-11-26
DOI
10.1186/s13065-015-0143-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Behavioral Phenotyping of a Transgenic Caenorhabditis Elegans Expressing Neuronal Amyloid-β
- (2017) Laura E. Dosanjh et al. JOURNAL OF ALZHEIMERS DISEASE
- Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway
- (2015) Shashi Kant Tiwari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neuroprotective Effects of the Cultivated Chondrus crispus in a C. elegans Model of Parkinson’s Disease
- (2015) Jinghua Liu et al. Marine Drugs
- Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression
- (2015) Xi Chen et al. Molecular Neurodegeneration
- Carqueja (Baccharis trimera) Protects against Oxidative Stress andβ-Amyloid-Induced Toxicity inCaenorhabditis elegans
- (2015) Franciny Aparecida Paiva et al. Oxidative Medicine and Cellular Longevity
- Cysteine string protein (CSP) and its role in preventing neurodegeneration
- (2015) Robert D. Burgoyne et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Neuroprotective effects of dietary restriction: Evidence and mechanisms
- (2015) Giovambattista Pani SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components
- (2015) Hannah V. McCue et al. Scientific Reports
- Spermidine protects against α-synuclein neurotoxicity
- (2014) Sabrina Büttner et al. CELL CYCLE
- Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol
- (2014) Sudhanva S. Kashyap et al. HUMAN MOLECULAR GENETICS
- Salidroside Protects Caenorhabditis elegans Neurons from Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress
- (2014) Lingyun Xiao et al. MOLECULES
- n-Butylidenephthalide Protects against Dopaminergic Neuron Degeneration and α-Synuclein Accumulation in Caenorhabditis elegans Models of Parkinson's Disease
- (2014) Ru-Huei Fu et al. PLoS One
- Novel Polyglutamine Model Uncouples Proteotoxicity from Aging
- (2014) Nakeirah T. M. Christie et al. PLoS One
- Clioquinol promotes the degradation of metal-dependent amyloid- (A ) oligomers to restore endocytosis and ameliorate A toxicity
- (2014) K. E. S. Matlack et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis
- (2013) Jia Li et al. ACTA PHARMACOLOGICA SINICA
- CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration
- (2013) Nicole F. Liachko et al. ANNALS OF NEUROLOGY
- Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
- (2013) Filipe Cabreiro et al. CELL
- Exciting Prospects for Precise Engineering of Caenorhabditis elegans Genomes with CRISPR/Cas9
- (2013) Christian Frøkjær-Jensen GENETICS
- Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity
- (2013) Arnaud Tauffenberger et al. NEUROBIOLOGY OF AGING
- Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease
- (2013) Ru-Huei Fu et al. NEUROPHARMACOLOGY
- Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling
- (2013) Bwarenaba B. Kautu et al. NEUROSCIENCE LETTERS
- Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit
- (2013) Luisa Diomede et al. PLoS One
- Pharmacological Activation of Sirt1 Ameliorates Polyglutamine-Induced Toxicity through the Regulation of Autophagy
- (2013) Bae Hyun Shin et al. PLoS One
- Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
- (2013) B. P. Hubbard et al. SCIENCE
- Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans
- (2013) Carmen I. Nussbaum-Krammer et al. PLoS Genetics
- Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and Extends Lifespan of Caenorhabditis elegans
- (2012) Srinivas Ayyadevara et al. ANTIOXIDANTS & REDOX SIGNALING
- The neuronal ceroid-lipofuscinoses: A historical introduction
- (2012) Matti Haltia et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Dopamine D2 Receptor Antagonism Suppresses Tau Aggregation and Neurotoxicity
- (2012) Allyson V. McCormick et al. BIOLOGICAL PSYCHIATRY
- Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms
- (2012) Xi Chen et al. BMC GENOMICS
- Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons
- (2012) François-Xavier Lejeune et al. BMC GENOMICS
- Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
- (2012) Sung-Jun Park et al. CELL
- Neurotransmitter release mechanisms studied in Caenorhabditis elegans
- (2012) Jeff W. Barclay et al. CELL CALCIUM
- Recurrent mutations inDNAJC5cause autosomal dominant Kufs disease
- (2012) M Cadieux-Dion et al. CLINICAL GENETICS
- Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity
- (2012) Chronis Fatouros et al. HUMAN MOLECULAR GENETICS
- Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity
- (2012) C. Yao et al. HUMAN MOLECULAR GENETICS
- Phosphorylation of α-Synuclein Protein at Ser-129 Reduces Neuronal Dysfunction by Lowering Its Membrane Binding Property inCaenorhabditis elegans
- (2012) Tomoki Kuwahara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The neuroprotective and lifespan-extension activities of Damnacanthus officinarum extracts in Caenorhabditis elegans
- (2012) Xiliang Yang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Pan-Neuronal Expression of APL-1, an APP-Related Protein, Disrupts Olfactory, Gustatory, and Touch Plasticity in Caenorhabditis elegans
- (2012) C. Y. Ewald et al. JOURNAL OF NEUROSCIENCE
- Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease
- (2012) Gawain McColl et al. Molecular Neurodegeneration
- Mutations in the Gene DNAJC5 Cause Autosomal Dominant Kufs Disease in a Proportion of Cases: Study of the Parry Family and 8 Other Families
- (2012) Milen Velinov et al. PLoS One
- Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio
- (2012) Alexandra Vaccaro et al. PLoS One
- Liuwei Dihuang (LWDH), a Traditional Chinese Medicinal Formula, Protects against β-Amyloid Toxicity in Transgenic Caenorhabditis elegans
- (2012) Jatinder S. Sangha et al. PLoS One
- Forward Genetic Analysis to Identify Determinants of Dopamine Signaling in Caenorhabditis elegans Using Swimming-Induced Paralysis
- (2012) J. Andrew Hardaway et al. G3-Genes Genomes Genetics
- Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity
- (2011) Tsui-Ting Ching et al. AGING CELL
- Mutations in DNAJC5, Encoding Cysteine-String Protein Alpha, Cause Autosomal-Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis
- (2011) Lenka Nosková et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease
- (2011) D. F.F. Silva et al. Current Alzheimer Research
- TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling
- (2011) Tao Zhang et al. HUMAN MOLECULAR GENETICS
- Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans : rescue by the DAF-16 and HSF-1 pathways
- (2011) Andreia Teixeira-Castro et al. HUMAN MOLECULAR GENETICS
- Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
- (2011) Zhaohui Liu et al. HUMAN MOLECULAR GENETICS
- The Novel Hydroxylamine Derivative NG-094 Suppresses Polyglutamine Protein Toxicity inCaenorhabditis elegans
- (2011) Pierre Haldimann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms
- (2011) Daniel F. Tardiff et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
- (2011) Silvestre Alavez et al. NATURE
- How were new medicines discovered?
- (2011) David C. Swinney et al. NATURE REVIEWS DRUG DISCOVERY
- Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development
- (2011) Dagmar E. Ehrnhoefer et al. NATURE REVIEWS DRUG DISCOVERY
- Effect of Phenolic Compounds Against Aβ Aggregation and Aβ-Induced Toxicity in Transgenic C. elegans
- (2011) Seema Jagota et al. NEUROCHEMICAL RESEARCH
- Icariin and its Derivative Icariside II Extend Healthspan via Insulin/IGF-1 Pathway in C. elegans
- (2011) Wai-Jiao Cai et al. PLoS One
- Exome-Sequencing Confirms DNAJC5 Mutations as Cause of Adult Neuronal Ceroid-Lipofuscinosis
- (2011) Bruno A. Benitez et al. PLoS One
- FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity
- (2011) Alex Lublin et al. PLoS One
- Prion protein inCaenorhabditis elegans
- (2011) Kyung-Won Park et al. Prion
- Functional Links Between A Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast
- (2011) S. Treusch et al. SCIENCE
- Special Anniversary Review: Twenty-five years of human immunodeficiency virus research: successes and challenges
- (2010) R. A. Weiss CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Genetic Mechanisms of Coffee Extract Protection in a Caenorhabditis elegans Model of -Amyloid Peptide Toxicity
- (2010) V. Dostal et al. GENETICS
- Neurotoxic effects of TDP-43 overexpression in C. elegans
- (2010) Peter E.A. Ash et al. HUMAN MOLECULAR GENETICS
- A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds
- (2010) J. N. Sleigh et al. HUMAN MOLECULAR GENETICS
- Inflammation in neurodegenerative diseases
- (2010) Sandra Amor et al. IMMUNOLOGY
- Neuron Dysfunction Is Induced by Prion Protein with an Insertional Mutation via a Fyn Kinase and Reversed by Sirtuin Activation in Caenorhabditis elegans
- (2010) N. Bizat et al. JOURNAL OF NEUROSCIENCE
- Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 Proteinopathy
- (2010) N. F. Liachko et al. JOURNAL OF NEUROSCIENCE
- Resveratrol, sirtuins, and the promise of a DR mimetic
- (2010) Joseph A. Baur MECHANISMS OF AGEING AND DEVELOPMENT
- A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans
- (2010) Andrew R Burns et al. Nature Chemical Biology
- Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers
- (2010) Luisa Diomede et al. NEUROBIOLOGY OF DISEASE
- LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease
- (2010) Chen Yao et al. NEUROBIOLOGY OF DISEASE
- Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans
- (2010) Roongpetch Keowkase et al. NEUROPHARMACOLOGY
- Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway
- (2010) S. Abbas et al. PHYTOMEDICINE
- Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models
- (2009) Damla Pinar Karpinar et al. EMBO JOURNAL
- Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms
- (2009) Tjakko J. van Ham et al. EMBO Molecular Medicine
- Reserpine ameliorates Aβ toxicity in the Alzheimer’s disease model in Caenorhabditis elegans
- (2009) Upasna Arya et al. EXPERIMENTAL GERONTOLOGY
- Caenorhabditits elegansLRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth
- (2009) Julia Sämann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans
- (2009) S. Saha et al. JOURNAL OF NEUROSCIENCE
- VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease
- (2009) Qingmin Ruan et al. NEUROBIOLOGY OF DISEASE
- Investigating Bacterial Sources of Toxicity as an Environmental Contributor to Dopaminergic Neurodegeneration
- (2009) Kim A. Caldwell et al. PLoS One
- An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans
- (2009) Jiou Wang et al. PLoS Genetics
- Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity
- (2009) Tali Gidalevitz et al. PLoS Genetics
- Protein Misfolding and Neurodegeneration
- (2008) Claudio Soto et al. ARCHIVES OF NEUROLOGY
- Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation
- (2008) Heidrun Witan et al. HUMAN MOLECULAR GENETICS
- Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan
- (2008) M. Briese et al. HUMAN MOLECULAR GENETICS
- A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans
- (2008) Tomoki Kuwahara et al. HUMAN MOLECULAR GENETICS
- Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
- (2008) Saravanan S. Karuppagounder et al. NEUROCHEMISTRY INTERNATIONAL
- Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease
- (2008) Cody J. Locke et al. NEUROSCIENCE LETTERS
- Epigallocatechin Gallate from Green Tea (Camellia sinensis) Increases Lifespan and Stress Resistance inCaenorhabditis elegans
- (2008) Sami Abbas et al. PLANTA MEDICA
- Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model
- (2008) S. Hamamichi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging
- (2008) Tjakko J. van Ham et al. PLoS Genetics
- A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau
- (2007) Roland Brandt et al. NEUROBIOLOGY OF AGING
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started