Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2 and autophagy pathways

S-allyl-l-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress

(2016) Isabel Denzer et al.   FOOD CHEMISTRY

Protection of retinal function by sulforaphane following retinal ischemic injury

(2015) Lindsay A. Ambrecht et al.   EXPERIMENTAL EYE RESEARCH

Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells

(2015) Gregory W. Watson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Rotenone impairs autophagic flux and lysosomal functions in Parkinson’s disease

(2015) F. Wu et al.   NEUROSCIENCE

Sulforaphane protects human umbilical vein cells against lipotoxicity by stimulating autophagy via an AMPK-mediated pathway

(2015) Ning Wang et al.   Journal of Functional Foods

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease

(2014) Yijiao Xu et al.   CELLULAR SIGNALLING

Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling

(2014) Hui Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

(2014) N. G. Innamorato et al.   JOURNAL OF IMMUNOLOGY

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease

(2014) Yanying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Sulforaphane alleviates scopolamine-induced memory impairment in mice

(2014) Siyoung Lee et al.   PHARMACOLOGICAL RESEARCH

Salvianolic Acid B Attenuates Toxin-Induced Neuronal Damage via Nrf2-Dependent Glial Cells-Mediated Protective Activity in Parkinson’s Disease Models

(2014) Jie Zhou et al.   PLoS One

Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

(2014) Qian Zhou et al.   TOXICOLOGICAL SCIENCES

Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function

(2014) Xin Jiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis

(2013) Richard Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Sulforaphane Attenuates Gentamicin-Induced Nephrotoxicity: Role of Mitochondrial Protection

(2013) Mario Negrette-Guzmán et al.   Evidence-based Complementary and Alternative Medicine

Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice

(2013) Bin Li et al.   EXPERIMENTAL NEUROLOGY

Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

(2013) Laurie H. Sanders et al.   FREE RADICAL BIOLOGY AND MEDICINE

N-acetyl-L-cysteine protects against cadmium-induced neuronal apoptosis by inhibiting ROS-dependent activation of Akt/mTOR pathway in mouse brain

(2013) Sujuan Chen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neuroprotective and Anti-inflammatory Properties of a Coffee Component in the MPTP Model of Parkinson’s Disease

(2013) Kang-Woo Lee et al.   Neurotherapeutics

Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease

(2013) Fabiana Morroni et al.   NEUROTOXICOLOGY

Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases

(2013) Andrea Tarozzi et al.   Oxidative Medicine and Cellular Longevity

A Guide to Neurotoxic Animal Models of Parkinson's Disease

(2013) K. Tieu   Cold Spring Harbor Perspectives in Medicine

Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease models

(2012) Nian Xiong et al.   CRITICAL REVIEWS IN TOXICOLOGY

Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species

(2012) Peng Jia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Therapeutic Effects of Rapamycin on MPTP-Induced Parkinsonism in Mice

(2012) Kangyong Liu et al.   NEUROCHEMICAL RESEARCH

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

(2012) Zhao Zhong Chong et al.   PROGRESS IN NEUROBIOLOGY

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

Parkinsonian Rotenone Mouse Model: Reevaluation of Long-Term Administration of Rotenone in C57BL/6 Mice

(2011) Masatoshi Inden et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Potential autophagy enhancers attenuate rotenone-induced toxicity in SH-SY5Y

(2011) N. Xiong et al.   NEUROSCIENCE

Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: Modulation by the Nrf2/Trx axis

(2010) Mireia Niso-Santano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 Induces Interleukin-6 (IL-6) Expression via an Antioxidant Response Element within the IL-6 Promoter

(2010) Christoph Jan Wruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage

(2010) Petra Bergström et al.   NEUROPHARMACOLOGY

Autophagy protects the rotenone-induced cell death in α-synuclein overexpressing SH-SY5Y cells

(2010) Shorafidinkhuja Dadakhujaev et al.   NEUROSCIENCE LETTERS

Environmental toxins and Parkinson’s disease: Putative roles of impaired electron transport chain and oxidative stress

(2010) Ibrahim Abdulwahid Arif et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line

(2009) Andrea Tarozzi et al.   JOURNAL OF NEUROCHEMISTRY

A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death

(2009) Kyou-Chan Choi et al.   JOURNAL OF NEUROCHEMISTRY

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

(2009) Lichuan Yang et al.   PLoS One

Stereotaxical Infusion of Rotenone: A Reliable Rodent Model for Parkinson's Disease

(2009) Nian Xiong et al.   PLoS One

Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson's Disease

(2008) K. Trinh et al.   JOURNAL OF NEUROSCIENCE