Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin

Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications

(2014) Ximena Paredes-Gonzalez et al.   AAPS Journal

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Luteolin Inhibits Human Keratinocyte Activation and Decreases NF-κB Induction That Is Increased in Psoriatic Skin

(2014) Zuyi Weng et al.   PLoS One

Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages

(2014) Constance Lay Saw et al.   Cell and Bioscience

Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2

(2013) Ludmila F.M.F. Cardozo et al.   BIOCHIMIE

Effects of natural phytochemicals inAngelica sinensis(Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation

(2013) Constance Lay Lay Saw et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells

(2013) Young-Mi Kang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Luteolin and luteolin-7-O-glucoside inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-κB/AP-1/PI3K-Akt signaling cascades in RAW 264.7 cells

(2013) Chung Mu Park et al.   Nutrition Research and Practice

Cytosolic PhospholipaseA2 Inhibition with PLA-695 Radiosensitizes Tumors in Lung Cancer Animal Models

(2013) Dinesh Thotala et al.   PLoS One

MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation

(2013) Yu-Jin Hwang et al.   Scientific Reports

Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes

(2012) Chin-Shiu Huang et al.   ARCHIVES OF TOXICOLOGY

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Src kinase is a direct target of apigenin against UVB-induced skin inflammation

(2012) Sanguine Byun et al.   CARCINOGENESIS

Nrf2 knockout enhances intestinal tumorigenesis inApcmin/+mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation

(2012) Ka Lung Cheung et al.   MOLECULAR CARCINOGENESIS

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression

(2012) Jong Hun Lee et al.   PHARMACOLOGY & THERAPEUTICS

Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates

(2011) Constance Lay-Lay Saw et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Involvement of catalase in the apoptotic mechanism induced by apigenin in HepG2 human hepatoma cells

(2011) Glaucio Valdameri et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Regulation of NF-E2-Related Factor 2 Signaling for Cancer Chemoprevention: Antioxidant Coupled with Antiinflammatory

(2010) Rong Hu et al.   ANTIOXIDANTS & REDOX SIGNALING

Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane

(2010) Constance L. Saw et al.   MOLECULAR CARCINOGENESIS

Apigenin: A Promising Molecule for Cancer Prevention

(2010) Sanjeev Shukla et al.   PHARMACEUTICAL RESEARCH

Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

(2009) Zheng Sun et al.   PLoS One

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer

(2008) T. O. Khor et al.   Cancer Prevention Research

Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy

(2008) Yong Lin et al.   CURRENT CANCER DRUG TARGETS

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Update on Uses and Properties of Citrus Flavonoids: New Findings in Anticancer, Cardiovascular, and Anti-inflammatory Activity

(2008) O. Benavente-García et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways

(2007) Kyung-Jin Yun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY