Three-Dimensional Models of the Human Brain Development and Diseases

Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip

(2017) Stephanie Dauth et al.   JOURNAL OF NEUROPHYSIOLOGY

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

(2017) Ira Espuny-Camacho et al.   NEURON

Human tissues in a dish: The research and ethical implications of organoid technology

(2017) Annelien L. Bredenoord et al.   SCIENCE

Medical devices on chips

(2017) Allan Guan et al.   Nature Biomedical Engineering

Messenger RNAs localized to distal projections of human stem cell derived neurons

(2017) Rebecca L. Bigler et al.   Scientific Reports

Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics

(2016) Carlo Sala Frigerio et al.   Annual Review of Neuroscience

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

(2016) Amy R. Nelson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Complex Tissue and Disease Modeling using hiPSCs

(2016) Robert Passier et al.   Cell Stem Cell

Neural Differentiation in the Third Dimension: Generating a Human Midbrain

(2016) Rebecca M. Marton et al.   Cell Stem Cell

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Dishing out mini-brains: Current progress and future prospects in brain organoid research

(2016) Iva Kelava et al.   DEVELOPMENTAL BIOLOGY

Organoid biobanking: identifying the ethics

(2016) Sarah N Boers et al.   EMBO REPORTS

The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates

(2016) Maria J. Pinto et al.   JOURNAL OF CELL BIOLOGY

Compartmentalized Microfluidic Platforms: The Unrivaled Breakthrough of In Vitro Tools for Neurobiological Research

(2016) Estrela Neto et al.   JOURNAL OF NEUROSCIENCE

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis

(2016) Onur Kilic et al.   LAB ON A CHIP

Could clinical symptoms be a predictor of complications in Zika virus infection? – Authors' reply

(2016) Simon Cauchemez et al.   LANCET

Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study

(2016) Simon Cauchemez et al.   LANCET

3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”

(2016) Se Hoon Choi et al.   Molecular Neurodegeneration

The promises and challenges of human brain organoids as models of neuropsychiatric disease

(2016) Giorgia Quadrato et al.   NATURE MEDICINE

Opportunities and challenges in modeling human brain disorders in transgenic primates

(2016) Charles G Jennings et al.   NATURE NEUROSCIENCE

Building brains in a dish: Prospects for growing cerebral organoids from stem cells

(2016) John O. Mason et al.   NEUROSCIENCE

Spatially patterned matrix elasticity directs stem cell fate

(2016) Chun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zika virus in the Americas: Early epidemiological and genetic findings

(2016) N. R. Faria et al.   SCIENCE

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Engineering a Brain Cancer Chip for High-throughput Drug Screening

(2016) Yantao Fan et al.   Scientific Reports

Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders

(2016) Fabio Cavaliere et al.   Stem Cells International

The design of reversible hydrogels to capture extracellular matrix dynamics

(2016) Adrianne M. Rosales et al.   Nature Reviews Materials

Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units

(2016) S. G. M. Uzel et al.   Science Advances

Functional imaging of neuron–astrocyte interactions in a compartmentalized microfluidic device

(2016) Yandong Gao et al.   Microsystems & Nanoengineering

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells

(2016) Han-Kyu Lee et al.   PLoS One

Neuronal networks provide rapid neuroprotection against spreading toxicity

(2016) Andrew J. Samson et al.   Scientific Reports

Significant glial alterations in response to iron loading in a novel organotypic hippocampal slice culture model

(2016) Sinead Healy et al.   Scientific Reports

Alzheimer's in 3D culture: Challenges and perspectives

(2015) Carla D'Avanzo et al.   BIOESSAYS

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance

(2015) Shalini Menon et al.   DEVELOPMENTAL CELL

γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation

(2015) Carla D’Avanzo et al.   FASEB JOURNAL

In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches

(2015) Anette Wolff et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

(2015) JiSoo Park et al.   LAB ON A CHIP

Brain disorders across the lifespan

(2015) Roger I. Glass   NATURE

Modeling psychiatric disorders for developing effective treatments

(2015) Tobias Kaiser et al.   NATURE MEDICINE

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

In vitro bioengineered model of cortical brain tissue

(2015) Karolina Chwalek et al.   Nature Protocols

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model

(2015) Nina Daschil et al.   NEUROBIOLOGY OF AGING

Organotypic brain slice cultures: A review

(2015) C. Humpel   NEUROSCIENCE

Progress in material design for biomedical applications

(2015) Mark W. Tibbitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Measuring dynamic cell–material interactions and remodeling during 3D human mesenchymal stem cell migration in hydrogels

(2015) Kelly M. Schultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Swimming muscles power suction feeding in largemouth bass

(2015) Ariel L. Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3D in vitro modeling of the central nervous system

(2015) Amy M. Hopkins et al.   PROGRESS IN NEUROBIOLOGY

Cell Migration on Planar and Three-Dimensional Matrices: A Hydrogel-Based Perspective

(2015) Lucas T. Vu et al.   TISSUE ENGINEERING PART B-REVIEWS

Central Nervous System and its Disease Models on a Chip

(2015) YoonYoung Yi et al.   TRENDS IN BIOTECHNOLOGY

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures

(2015) Sabine Hellwig et al.   Scientific Reports

Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology

(2015) Hansang Cho et al.   Scientific Reports

Networked neural spheroid by neuro-bundle mimicking nervous system created by topology effect

(2015) Gi Seok Jeong et al.   Molecular Brain

Serum-Induced Differentiation of Glioblastoma Neurospheres Leads to Enhanced Migration/Invasion Capacity That Is Associated with Increased MMP9

(2015) Justin V. Joseph et al.   PLoS One

A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip

(2015) Sudhir P. Deosarkar et al.   PLoS One

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

Bioengineering approaches to guide stem cell-based organogenesis

(2014) Nikolche Gjorevski et al.   DEVELOPMENT

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

In Vitro Models of the Blood–Brain Barrier for the Study of Drug Delivery to the Brain

(2014) Imola Wilhelm et al.   MOLECULAR PHARMACEUTICS

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Toward in vitro models of brain structure and function

(2014) M. L. Shuler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioengineered functional brain-like cortical tissue

(2014) M. D. Tang-Schomer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

3D niche microarrays for systems-level analyses of cell fate

(2014) A. Ranga et al.   Nature Communications

3D Reconstitution of the Patterned Neural Tube from Embryonic Stem Cells

(2014) Andrea Meinhardt et al.   Stem Cell Reports

Cell-Material Interactions Revealed Via Material Techniques of Surface Patterning

(2013) Xiang Yao et al.   ADVANCED MATERIALS

Size-controllable networked neurospheres as a 3D neuronal tissue model for Alzheimer's disease studies

(2013) Yoon Jung Choi et al.   BIOMATERIALS

A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons

(2013) Dawei Zhang et al.   BIOMATERIALS

Cerebral Organoids in a Dish: Progress and Prospects

(2013) Marina Bershteyn et al.   CELL

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Build-a-Brain

(2013) Stuart M. Chambers et al.   Cell Stem Cell

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Organotypic cultures as tools for optimizing central nervous system cell therapies

(2013) Nicolas Daviaud et al.   EXPERIMENTAL NEUROLOGY

Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS

(2013) Anja Kunze et al.   Integrative Biology

Modeling human neurological disorders with induced pluripotent stem cells

(2013) Yoichi Imaizumi et al.   JOURNAL OF NEUROCHEMISTRY

Axonal Translation of  -Catenin Regulates Synaptic Vesicle Dynamics

(2013) A. M. Taylor et al.   JOURNAL OF NEUROSCIENCE

Advances in microfluidics-based experimental methods for neuroscience research

(2013) Jae Woo Park et al.   LAB ON A CHIP

Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts

(2013) Mingjian Shi et al.   LAB ON A CHIP

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Lighting the way

(2013) Daniel L. Alge et al.   NATURE MATERIALS

In situ cell manipulation through enzymatic hydrogel photopatterning

(2013) Katarzyna A. Mosiewicz et al.   NATURE MATERIALS

Opportunities and challenges of pluripotent stem cell neurodegenerative disease models

(2013) Jackson Sandoe et al.   NATURE NEUROSCIENCE

Cortical Evolution: Judge the Brain by Its Cover

(2013) Daniel H. Geschwind et al.   NEURON

Robust Formation and Maintenance of Continuous Stratified Cortical Neuroepithelium by Laminin-Containing Matrix in Mouse ES Cell Culture

(2013) Makoto Nasu et al.   PLoS One

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What Are Mini-Brains?

(2013) B.-i. Bae et al.   SCIENCE

Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier

(2013) Eduard Urich et al.   Scientific Reports

Microfluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-β on Microglial Accumulation

(2013) Hansang Cho et al.   Scientific Reports

Neurotoxic amyloid beta oligomeric assemblies recreated in microfluidic platform with interstitial level of slow flow

(2013) Yoon Jung Choi et al.   Scientific Reports

Quantitative Analysis of Axonal Transport by Using Compartmentalized and Surface Micropatterned Culture of Neurons

(2012) Hyung Joon Kim et al.   ACS Chemical Neuroscience

Presenilin-1 L166P Mutant Human Pluripotent Stem Cell–Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-β Generation

(2012) Philipp Koch et al.   AMERICAN JOURNAL OF PATHOLOGY

Spindle orientation in mammalian cerebral cortical development

(2012) Madeline A Lancaster et al.   CURRENT OPINION IN NEUROBIOLOGY

Functional connectivity and dynamics of cortical–thalamic networks co-cultured in a dual compartment device

(2012) Thirukumaran T Kanagasabapathi et al.   Journal of Neural Engineering

A microdevice platform for visualizing mitochondrial transport in aligned dopaminergic axons

(2012) Xi Lu et al.   JOURNAL OF NEUROSCIENCE METHODS

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

Materials science: Cell environments programmed with light

(2012) Matthias P. Lutolf   NATURE

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Precise Spatial and Temporal Control of Oxygen within In Vitro Brain Slices via Microfluidic Gas Channels

(2012) Gerardo Mauleon et al.   PLoS One

Designing Cell-Compatible Hydrogels for Biomedical Applications

(2012) D. Seliktar   SCIENCE

Dynamic Microenvironments: The Fourth Dimension

(2012) M. W. Tibbitt et al.   Science Translational Medicine

New perspectives on neuronal development via microfluidic environments

(2012) Larry J. Millet et al.   TRENDS IN NEUROSCIENCES

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

(2011) Yosuke Nakao et al.   Biomicrofluidics

Development and Evolution of the Human Neocortex

(2011) Jan H. Lui et al.   CELL

Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells

(2011) Erika Pastrana et al.   Cell Stem Cell

Modeling familial Alzheimer's disease with induced pluripotent stem cells

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

Organotypic vibrosections: Novel whole sagittal brain cultures

(2011) Celine Ullrich et al.   JOURNAL OF NEUROSCIENCE METHODS

In Vitro Blood–Brain Barrier Models: Current and Perspective Technologies

(2011) Pooja Naik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers

(2011) Jean-Michel Peyrin et al.   LAB ON A CHIP

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action

(2011) Fernando Kreutz et al.   NEUROCHEMISTRY INTERNATIONAL

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Functional Integration of Grafted Neural Stem Cell-Derived Dopaminergic Neurons Monitored by Optogenetics in an In Vitro Parkinson Model

(2011) Jan Tønnesen et al.   PLoS One

Silencing GADD153/CHOP Gene Expression Protects against Alzheimer's Disease-Like Pathology Induced by 27-Hydroxycholesterol in Rabbit Hippocampus

(2011) Jaya R. P. Prasanthi et al.   PLoS One

Neurotrophin-mediated dendrite-to-nucleus signaling revealed by microfluidic compartmentalization of dendrites

(2011) M. S. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synapse microarray identification of small molecules that enhance synaptogenesis

(2011) Peng Shi et al.   Nature Communications

A neurospheroid network-stamping method for neural transplantation to the brain

(2010) Midori Kato-Negishi et al.   BIOMATERIALS

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

Micro-scale and microfluidic devices for neurobiology

(2010) Anne M Taylor et al.   CURRENT OPINION IN NEUROBIOLOGY

An organotypic culture model to study nigro-striatal degeneration

(2010) Fabio Cavaliere et al.   JOURNAL OF NEUROSCIENCE METHODS

A novel method for inducing focal ischemia in vitro

(2010) Marc J.P. Richard et al.   JOURNAL OF NEUROSCIENCE METHODS

Co-culture of neurons and glia in a novel microfluidic platform

(2010) Devi Majumdar et al.   JOURNAL OF NEUROSCIENCE METHODS

An automated microfluidic platform for calcium imaging of chemosensory neurons in Caenorhabditis elegans

(2010) Trushal Vijaykumar Chokshi et al.   LAB ON A CHIP

Microfluidic dissolved oxygen gradient generator biochip as a useful tool in bacterial biofilm studies

(2010) Maciej Skolimowski et al.   LAB ON A CHIP

Oxygen gradients for open well cellular cultures via microfluidic substrates

(2010) Joe F. Lo et al.   LAB ON A CHIP

Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke

(2010) Susanna Camós et al.   MOLECULES

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

Synthesis of photodegradable hydrogels as dynamically tunable cell culture platforms

(2010) April M Kloxin et al.   Nature Protocols

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

(2010) Dan Shlosberg et al.   Nature Reviews Neurology

Graft and host interactions following transplantation of neural stem cells to organotypic striatal cultures

(2010) Linda Maria Jäderstad et al.   Regenerative Medicine

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons

(2009) A. M. Taylor et al.   JOURNAL OF NEUROSCIENCE

Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures

(2009) Mark Polinkovsky et al.   LAB ON A CHIP

Generation of oxygen gradients with arbitrary shapes in a microfluidic device

(2009) Micha Adler et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Designing materials to direct stem-cell fate

(2009) Matthias P. Lutolf et al.   NATURE

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments

(2009) Cole A. DeForest et al.   NATURE MATERIALS

β-Amyloid impairs axonal BDNF retrograde trafficking

(2009) Wayne W. Poon et al.   NEUROBIOLOGY OF AGING

Modulating Temporal and Spatial Oxygenation over Adherent Cellular Cultures

(2009) Shawn C. Oppegard et al.   PLoS One

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain

(2008) J. An et al.   BLOOD

Microfluidics: A new cosset for neurobiology

(2008) Jinyi Wang et al.   LAB ON A CHIP

The 3Ms of central spindle assembly: microtubules, motors and MAPs

(2008) Michael Glotzer   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON