The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease
Authors
Keywords
-
Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2018-09-30
DOI
10.1111/ejn.14182
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo
- (2018) Elena Kozina et al. BRAIN
- Depletion of microglia augments the dopaminergic neurotoxicity of MPTP
- (2018) Xiaoxia Yang et al. FASEB JOURNAL
- Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein
- (2018) Jimena Hebe Martinez et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
- (2018) Seung Pil Yun et al. NATURE MEDICINE
- Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology
- (2018) Fredric P. Manfredsson et al. NEUROBIOLOGY OF DISEASE
- Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons
- (2018) Jason Schapansky et al. NEUROBIOLOGY OF DISEASE
- Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice
- (2018) Yulan Xiong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease
- (2018) Diego Grassi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LRRK2 kinase in Parkinson's disease
- (2018) Dario R. Alessi et al. SCIENCE
- An Inflammation-Centric View of Neurological Disease: Beyond the Neuron
- (2018) Stephen D. Skaper et al. Frontiers in Cellular Neuroscience
- Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein
- (2018) Tammy Ryan et al. Nature Communications
- Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity
- (2018) Matthew J. Benskey et al. Frontiers in Molecular Neuroscience
- Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?
- (2018) Michael R. Post et al. Frontiers in Neuroscience
- Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease
- (2018) Géraldine Gelders et al. Journal of Immunology Research
- Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain
- (2018) Tatiana V. Tarasova et al. PeerJ
- Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
- (2017) Andrew B. West EXPERIMENTAL NEUROLOGY
- Parkinson’s Disease: From Pathogenesis to Pharmacogenomics
- (2017) Ramón Cacabelos INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Parkinson's Disease Is Not Simply a Prion Disorder
- (2017) D. James Surmeier et al. JOURNAL OF NEUROSCIENCE
- Overexpression of α-synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis
- (2017) Adolfo Garcia Erustes et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
- (2017) Veronica Lindström et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
- (2017) Yvette C Wong et al. NATURE MEDICINE
- Selective neuronal vulnerability in Parkinson disease
- (2017) D. James Surmeier et al. NATURE REVIEWS NEUROSCIENCE
- α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration
- (2017) Hisham Abdelmotilib et al. NEUROBIOLOGY OF DISEASE
- The Threshold Theory for Parkinson's Disease
- (2017) Simone Engelender et al. TRENDS IN NEUROSCIENCES
- αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease
- (2017) Victorio Martin Pozo Devoto et al. Scientific Reports
- Increased Oxidative Stress Markers in Cerebrospinal Fluid from Healthy Subjects with Parkinson’s Disease-Associated LRRK2 Gene Mutations
- (2017) David A. Loeffler et al. Frontiers in Aging Neuroscience
- LRRK2 G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson’s Disease
- (2017) Ahmed Bouhouche et al. Parkinsons Disease
- PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2
- (2017) Laura Civiero et al. Frontiers in Molecular Neuroscience
- Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
- (2017) Francesco Longo et al. Acta Neuropathologica Communications
- Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes
- (2017) Jakob Domert et al. PLoS One
- Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats
- (2016) Maria Xilouri et al. Autophagy
- Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia
- (2016) Tatsunori Maekawa et al. BMC NEUROSCIENCE
- LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?
- (2016) Jean-Marc Taymans et al. Current Neuropharmacology
- LRRK2 modulates microglial activity through regulation of chemokine (C–X3–C) receptor 1 –mediated signalling pathways
- (2016) Bo Ma et al. HUMAN MOLECULAR GENETICS
- Rab7 induces clearance of α-synuclein aggregates
- (2016) Elisabeth Dinter et al. JOURNAL OF NEUROCHEMISTRY
- G2019S-LRRK2 Expression Augments -Synuclein Sequestration into Inclusions in Neurons
- (2016) L. A. Volpicelli-Daley et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease
- (2016) Roberto Di Maio et al. Science Translational Medicine
- Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson’s disease
- (2016) T. Q. Melo et al. EXPERIMENTAL BRAIN RESEARCH
- mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1
- (2016) Claudia Manzoni et al. Scientific Reports
- Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease
- (2015) A. Gustot et al. BIOCHEMICAL JOURNAL
- LRRK2 mutations and neurotoxicant susceptibility
- (2015) Jang-Won Lee et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening
- (2015) Nicholas J. Lavalley et al. HUMAN MOLECULAR GENETICS
- Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration
- (2015) João P. L. Daher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A53T Human -Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration
- (2015) L. Chen et al. JOURNAL OF NEUROSCIENCE
- Leucine-Rich Repeat Kinase 2 Modulates Neuroinflammation and Neurotoxicity in Models of Human Immunodeficiency Virus 1-Associated Neurocognitive Disorders
- (2015) J. M. Puccini et al. JOURNAL OF NEUROSCIENCE
- Mutations in LRRK2 potentiate age-related impairment of autophagic flux
- (2015) Shamol Saha et al. Molecular Neurodegeneration
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function
- (2015) Kerstin Buck et al. NEUROBIOLOGY OF DISEASE
- Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins
- (2015) Sunny Rae Slone et al. NEUROBIOLOGY OF DISEASE
- Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
- (2015) Katrina L. Paumier et al. NEUROBIOLOGY OF DISEASE
- Greater motor progression in patients with Parkinson disease who carryLRRK2risk variants
- (2015) Linda P. Oosterveld et al. NEUROLOGY
- UDCA exerts beneficial effect on mitochondrial dysfunction inLRRK2G2019Scarriers and in vivo
- (2015) Heather Mortiboys et al. NEUROLOGY
- Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders
- (2015) Stefano G. Daniele et al. Science Signaling
- Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
- (2015) A K Reeve et al. Cell Death & Disease
- Couldα-Synuclein Amyloid-Like Aggregates Trigger a Prionic Neuronal Invasion?
- (2015) Maria Antònia Busquets et al. Biomed Research International
- Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease
- (2015) Lorraine V. Kalia et al. JAMA Neurology
- Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders
- (2015) Stefano G. Daniele et al. Science Signaling
- Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo
- (2014) M. W. Dodson et al. Disease Models & Mechanisms
- Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China
- (2014) D Wang et al. GENES AND IMMUNITY
- Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
- (2014) J. Schapansky et al. HUMAN MOLECULAR GENETICS
- Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution
- (2014) Adamantios Mamais et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- -Synuclein Is Localized to Mitochondria-Associated ER Membranes
- (2014) C. Guardia-Laguarta et al. JOURNAL OF NEUROSCIENCE
- Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies
- (2014) G. Skibinski et al. JOURNAL OF NEUROSCIENCE
- Motor progression of Parkinson's disease with the leucine-rich repeat kinase 2 G2019S mutation
- (2014) Gilad Yahalom et al. MOVEMENT DISORDERS
- Ten Years and Counting: Moving Leucine-Rich RepeatKinase 2 Inhibitors to the Clinic
- (2014) Andrew B. West MOVEMENT DISORDERS
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- (2014) Mike A Nalls et al. NATURE GENETICS
- Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein
- (2014) Sudhakar Raja Subramaniam et al. NEUROBIOLOGY OF DISEASE
- Abrogation of -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats
- (2014) J. P. L. Daher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling
- (2014) S Saez-Atienzar et al. Cell Death & Disease
- Alpha-synuclein spreading in Parkinson’s disease
- (2014) Ariadna Recasens et al. Frontiers in Neuroanatomy
- Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation
- (2013) Yu-Chin Su et al. HUMAN MOLECULAR GENETICS
- Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
- (2013) Selcuk A. Tanik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
- (2013) Anthony A. Estrada et al. JOURNAL OF MEDICINAL CHEMISTRY
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- Identification of a unique TGF-β–dependent molecular and functional signature in microglia
- (2013) Oleg Butovsky et al. NATURE NEUROSCIENCE
- Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity
- (2013) Dimitris N. Xanthos et al. NATURE REVIEWS NEUROSCIENCE
- A comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism
- (2013) Joanne Trinh et al. NEUROBIOLOGY OF AGING
- The Function of α-Synuclein
- (2013) Jacob T. Bendor et al. NEURON
- Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies
- (2013) Gaia Codolo et al. PLoS One
- Impairment of Mitochondria in Adult Mouse Brain Overexpressing Predominantly Full-Length, N-Terminally Acetylated Human α-Synuclein
- (2013) Theodore A. Sarafian et al. PLoS One
- LRRK2 and RIPK2 Variants in the NOD 2-Mediated Signaling Pathway Are Associated with Susceptibility to Mycobacterium leprae in Indian Populations
- (2013) Patrick Marcinek et al. PLoS One
- Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus
- (2013) Daniah Trabzuni et al. PLoS One
- Polo-like kinase 2 regulates selective autophagic -synuclein clearance and suppresses its toxicity in vivo
- (2013) A. Oueslati et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
- (2013) Changyoun Kim et al. Nature Communications
- The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway
- (2012) José M. Bravo-San Pedro et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Neurodegenerative phenotypes in an A53T -synuclein transgenic mouse model are independent of LRRK2
- (2012) J. P. L. Daher et al. HUMAN MOLECULAR GENETICS
- G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization
- (2012) Tatiana D. Papkovskaia et al. HUMAN MOLECULAR GENETICS
- LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1
- (2012) X. Wang et al. HUMAN MOLECULAR GENETICS
- α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease
- (2012) Isabel Lastres-Becker et al. HUMAN MOLECULAR GENETICS
- Aggregate Clearance of α-Synuclein inSaccharomyces cerevisiaeDepends More on Autophagosome and Vacuole Function Than on the Proteasome
- (2012) Doris Petroi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions
- (2012) Tito Calì et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants
- (2012) Teresa Botta-Orfila et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein
- (2012) Jingwen Niu et al. JOURNAL OF NEUROCHEMISTRY
- Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease
- (2012) Weilin Xie et al. JOURNAL OF NEUROCHEMISTRY
- Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy
- (2012) I. Ahmed et al. JOURNAL OF NEUROSCIENCE
- LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
- (2012) M. S. Moehle et al. JOURNAL OF NEUROSCIENCE
- Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of -Synuclein and LRRK2 in the Brain
- (2012) L. G. Friedman et al. JOURNAL OF NEUROSCIENCE
- Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
- (2012) F. Gillardon et al. NEUROSCIENCE
- High LRRK2 Levels Fail to Induce or Exacerbate Neuronal Alpha-Synucleinopathy in Mouse Brain
- (2012) Martin C. Herzig et al. PLoS One
- Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia
- (2012) Beomsue Kim et al. PLoS One
- LRRK2 A419V Is Not Associated with Parkinson's Disease in Different Chinese Populations
- (2012) Yih Ru Wu et al. PLoS One
- Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers
- (2012) Laura Civiero et al. PLoS One
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
- (2012) Z. Sheng et al. Science Translational Medicine
- Brain Penetrant LRRK2 Inhibitor
- (2012) Hwan Geun Choi et al. ACS Medicinal Chemistry Letters
- The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity
- (2012) Erin K. Butler et al. PLoS Genetics
- α-Synuclein Aggregation and Transmission Are Enhanced by Leucine-Rich Repeat Kinase 2 in Human Neuroblastoma SH-SY5Y Cells
- (2011) Kazunari Kondo et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Inclusion of a portion of the native SNCA 3′UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia Nigra
- (2011) Christina E. Khodr et al. Developmental Neurobiology
- Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
- (2011) M. W. Dodson et al. HUMAN MOLECULAR GENETICS
- Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
- (2011) Zhaohui Liu et al. HUMAN MOLECULAR GENETICS
- Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
- (2011) Ken Nakamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities
- (2011) Philip J. Webber et al. JOURNAL OF MOLECULAR BIOLOGY
- A Search for SNCA 3′ UTR Variants Identified SNP rs356165 as a Determinant of Disease Risk and Onset Age in Parkinson’s Disease
- (2011) Lucía F. Cardo et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
- (2011) Mansoureh Hakimi et al. JOURNAL OF NEURAL TRANSMISSION
- Authentically Phosphorylated -Synuclein at Ser129 Accelerates Neurodegeneration in a Rat Model of Familial Parkinson's Disease
- (2011) H. Sato et al. JOURNAL OF NEUROSCIENCE
- Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study
- (2011) Owen A Ross et al. LANCET NEUROLOGY
- Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
- (2011) Xianming Deng et al. Nature Chemical Biology
- Prion-like acceleration of a synucleinopathy in a transgenic mouse model
- (2011) Anne-Laure Mougenot et al. NEUROBIOLOGY OF AGING
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson’s disease susceptibility?
- (2011) Joanna M. Biernacka et al. PARKINSONISM & RELATED DISORDERS
- Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2
- (2011) David Ramonet et al. PLoS One
- Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation
- (2011) Jonathan Thévenet et al. PLoS One
- Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
- (2010) Lydia Alvarez-Erviti et al. ARCHIVES OF NEUROLOGY
- 14-3-3 proteins are promising LRRK2 interactors
- (2010) Iakov N. Rudenko et al. BIOCHEMICAL JOURNAL
- Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization
- (2010) Nicolas Dzamko et al. BIOCHEMICAL JOURNAL
- 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
- (2010) R. Jeremy Nichols et al. BIOCHEMICAL JOURNAL
- Membrane Localization of LRRK2 Is Associated with Increased Formation of the Highly Active LRRK2 Dimer and Changes in Its Phosphorylation
- (2010) Zdenek Berger et al. BIOCHEMISTRY
- Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
- (2010) Frits Kamp et al. EMBO JOURNAL
- The Transgenic Overexpression of α-Synuclein and Not Its Related Pathology Associates with Complex I Inhibition
- (2010) Virginie Loeb et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
- (2010) Ashley R. Winslow et al. JOURNAL OF CELL BIOLOGY
- LRRK2 Is Involved in the IFN- Response and Host Response to Pathogens
- (2010) A. Gardet et al. JOURNAL OF IMMUNOLOGY
- Pathogenic Lysosomal Depletion in Parkinson's Disease
- (2010) B. Dehay et al. JOURNAL OF NEUROSCIENCE
- Phosphopeptide Analysis Reveals Two Discrete Clusters of Phosphorylation in the N-Terminus and the Roc Domain of the Parkinson-Disease Associated Protein Kinase LRRK2
- (2010) Christian Johannes Gloeckner et al. JOURNAL OF PROTEOME RESEARCH
- In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration
- (2010) Oleg S Gorbatyuk et al. MOLECULAR THERAPY
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- (2010) Byoung Dae Lee et al. NATURE MEDICINE
- The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
- (2010) Mark R. Cookson NATURE REVIEWS NEUROSCIENCE
- Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2
- (2010) H. Mortiboys et al. NEUROLOGY
- Genetic Animal Models of Parkinson's Disease
- (2010) Ted M. Dawson et al. NEURON
- Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
- (2010) Shankar J. Chinta et al. NEUROSCIENCE LETTERS
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of the Autophosphorylation Sites of LRRK2
- (2009) Shogo Kamikawaji et al. BIOCHEMISTRY
- Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease
- (2009) K. Venderova et al. HUMAN MOLECULAR GENETICS
- LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
- (2009) Javier Alegre-Abarrategui et al. HUMAN MOLECULAR GENETICS
- Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease
- (2009) Shinji Higashi et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila
- (2009) C.-H. Ng et al. JOURNAL OF NEUROSCIENCE
- Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)
- (2009) E. Andres-Mateos et al. JOURNAL OF NEUROSCIENCE
- LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans
- (2009) S. Saha et al. JOURNAL OF NEUROSCIENCE
- LRRK2mutations and risk variants in Japanese patients with Parkinson's disease
- (2009) Cyrus P. Zabetian et al. MOVEMENT DISORDERS
- Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
- (2009) Wataru Satake et al. NATURE GENETICS
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
- (2009) Xian Lin et al. NEURON
- α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity
- (2009) Guangwei Liu et al. NEUROSCIENCE LETTERS
- Genomewide Association Study of Leprosy
- (2009) Fu-Ren Zhang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy
- (2009) Maria Xilouri et al. PLoS One
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease
- (2008) Saskia Biskup et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Semi-quantitative analysis of α-synuclein in subcellular pools of rat brain neurons: An immunogold electron microscopic study using a C-terminal specific monoclonal antibody
- (2008) Ling Zhang et al. BRAIN RESEARCH
- Mitochondrial association of alpha-synuclein causes oxidative stress
- (2008) M. S. Parihar et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Mitochondrial translocation of α-synuclein is promoted by intracellular acidification
- (2008) Nelson B. Cole et al. EXPERIMENTAL CELL RESEARCH
- Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells
- (2008) Tereza Vogiatzi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
- (2008) Latha Devi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System
- (2008) Kelly J. Inglis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- LRRK2 mutation in familial Parkinson’s disease in a Taiwanese population: clinical, PET, and functional studies
- (2008) Chin-Hsien Lin et al. JOURNAL OF BIOMEDICAL SCIENCE
- Optical Reporters for the Conformation of -Synuclein Reveal a Specific Interaction with Mitochondria
- (2008) K. Nakamura et al. JOURNAL OF NEUROSCIENCE
- LRRK2 Gly2019Ser penetrance in Arab–Berber patients from Tunisia: a case-control genetic study
- (2008) Mary M Hulihan et al. LANCET NEUROLOGY
- Mitochondria in the aetiology and pathogenesis of Parkinson's disease
- (2008) Anthony HV Schapira LANCET NEUROLOGY
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
- Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
- (2008) Jeffrey C Barrett et al. NATURE GENETICS
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- Familial parkinsonism: Study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes
- (2008) Kazuko Hasegawa et al. PARKINSONISM & RELATED DISORDERS
- The phosphorylation state of Ser-129 in human -synuclein determines neurodegeneration in a rat model of Parkinson disease
- (2008) O. S. Gorbatyuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transcriptional dysregulation in a transgenic model of Parkinson disease
- (2007) Talene A. Yacoubian et al. NEUROBIOLOGY OF DISEASE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now