Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation

Induction of CD83+CD14+ Nondendritic Antigen-Presenting Cells by Exposure of Monocytes to IFN- 

(2014) G. Gerlini et al.   JOURNAL OF IMMUNOLOGY

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

(2011) Xianming Deng et al.   Nature Chemical Biology

Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen

(2010) Tatsunori Maekawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation

(2010) Makoto Kubo et al.   JOURNAL OF NEUROIMMUNOLOGY

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

(2010) H.L. Melrose et al.   NEUROBIOLOGY OF DISEASE

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis

(2009) Etsuro Ohta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

(2009) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Comparison of gene expression profiles between human and mouse monocyte subsets

(2009) M. A. Ingersoll et al.   BLOOD

Is There an Association between the Level of High-Sensitivity C-Reactive Protein and Idiopathic Parkinson’s Disease? A Comparison of Parkinson’s Disease Patients, Disease Controls and Healthy Individuals

(2009) In-Uk Song et al.   EUROPEAN NEUROLOGY

Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)

(2009) E. Andres-Mateos et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Peripheral Chemo-Cytokine Profiles in Alzheimers and Parkinsons Diseases

(2009) M. Reale et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

Regulation of LRRK2 Stability by the E3 Ubiquitin Ligase CHIP

(2009) Xiaodong Ding et al.   PLoS One

The WD40 Domain Is Required for LRRK2 Neurotoxicity

(2009) Nathan D. Jorgensen et al.   PLoS One

Acute in vivo exposure to interferon-  enables resident brain dendritic cells to become effective antigen presenting cells

(2009) A. Gottfried-Blackmore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

(2009) Han Seok Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2in Parkinson's disease – drawing the curtain of penetrance: a commentary

(2008) Rejko Krüger   BMC Medicine

The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2

(2008) L. Wang et al.   JOURNAL OF NEUROSCIENCE

Growth rate of patient-derived lymphoblastoid cells with LRRK2 mutations

(2008) Eng-King Tan et al.   MOLECULAR GENETICS AND METABOLISM

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFα, and INFγ concentrations are elevated in patients with atypical and idiopathic parkinsonism

(2008) Bogdan Brodacki et al.   NEUROSCIENCE LETTERS