The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress

(2014) Ruben K. Dagda et al.   Autophagy

Does bafilomycin A1block the fusion of autophagosomes with lysosomes?

(2014) Daniel J. Klionsky et al.   Autophagy

α-Synuclein Aggregation and Transmission Are Enhanced by Leucine-Rich Repeat Kinase 2 in Human Neuroblastoma SH-SY5Y Cells

(2011) Kazunari Kondo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

(2011) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities

(2011) Philip J. Webber et al.   JOURNAL OF MOLECULAR BIOLOGY

Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition

(2011) Elizabeth A. Doggett et al.   JOURNAL OF NEUROCHEMISTRY

Pathological roles of α-synuclein in neurological disorders

(2011) Kostas Vekrellis et al.   LANCET NEUROLOGY

Interaction between -Synuclein and Other Proteins in Neurodegenerative Disorders

(2011) Kurt A. Jellinger   TheScientificWorldJOURNAL

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL

Leucine-rich repeat kinase 2 induces α-synuclein expression via the extracellular signal-regulated kinase pathway

(2010) Iria Carballo-Carbajal et al.   CELLULAR SIGNALLING

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients

(2010) A. Rakovic et al.   HUMAN MOLECULAR GENETICS

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

(2010) H. Mortiboys et al.   NEUROLOGY

Identification and Characterization of a Leucine-Rich Repeat Kinase 2 (LRRK2) Consensus Phosphorylation Motif

(2010) Pooja P. Pungaliya et al.   PLoS One

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

(2009) Hong Qing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of the Autophosphorylation Sites of LRRK2

(2009) Shogo Kamikawaji et al.   BIOCHEMISTRY

The IKK complex contributes to the induction of autophagy

(2009) Alfredo Criollo et al.   EMBO JOURNAL

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1

(2009) Jianrong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?

(2009) Frank Gillardon   JOURNAL OF NEUROCHEMISTRY

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7,in vitro

(2009) Christian Johannes Gloeckner et al.   JOURNAL OF NEUROCHEMISTRY

Silencing DJ-1 reveals its contribution in paraquat-induced autophagy

(2009) Rosa A. González-Polo et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

(2009) L. Parisiadou et al.   JOURNAL OF NEUROSCIENCE

Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)

(2009) E. Andres-Mateos et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein and LRRK2: Partners in Crime

(2009) Youren Tong et al.   NEURON

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

(2009) Xian Lin et al.   NEURON

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

(2009) Han Seok Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

(2008) Yuzuru Imai et al.   EMBO JOURNAL

LRRK2 regulates synaptic vesicle endocytosis

(2008) Narae Shin et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-α-induced cell death in MCF-7 cells

(2008) U. Sivaprasad et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

(2008) Payal N. Gandhi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

(2008) Anthony K.F. Liou et al.   NEUROBIOLOGY OF DISEASE