Designing in vitro Blood-Brain Barrier Models Reproducing Alterations in Brain Aging
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Designing in vitro Blood-Brain Barrier Models Reproducing Alterations in Brain Aging
Authors
Keywords
-
Journal
Frontiers in Aging Neuroscience
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-08-06
DOI
10.3389/fnagi.2018.00234
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Telomere uncapping and vascular aging
- (2018) R. Garrett Morgan et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction
- (2018) Santosh Karnewar et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties
- (2018) Taku Wakabayashi et al. Cell Stem Cell
- Human Hippocampal Neurogenesis Persists throughout Aging
- (2018) Maura Boldrini et al. Cell Stem Cell
- Modeling the Accumulation of Degradable Polymer Drug Carriers in the Brain
- (2018) Celine Bolwerk et al. ChemMedChem
- Sema4D/PlexinB1 inhibition ameliorates blood–brain barrier damage and improves outcome after stroke in rats
- (2018) Yi-Fan Zhou et al. FASEB JOURNAL
- Aged Mouse Cortical Microglia Display an Activation Profile Suggesting Immunotolerogenic Functions
- (2018) Tanja Zöller et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Normal aging induces A1-like astrocyte reactivity
- (2018) Laura E. Clarke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gliotransmitters and cytokines in the control of blood-brain barrier permeability
- (2018) Elena D. Osipova et al. REVIEWS IN THE NEUROSCIENCES
- The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging
- (2018) Eduardo N. Chini et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis
- (2018) Maria Ribecco-Lutkiewicz et al. Scientific Reports
- Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain
- (2018) Andrée-Anne Berthiaume et al. Cell Reports
- The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain
- (2018) Matthew M. Boisvert et al. Cell Reports
- Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies
- (2018) Collin D. Edington et al. Scientific Reports
- Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface
- (2017) Duc TT Phan et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
- (2017) Birgit Ritschka et al. GENES & DEVELOPMENT
- Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway
- (2017) Yanlin Yin et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood–brain barrier: mechanisms of brain clearing
- (2017) Oxana Semyachkina-Glushkovskaya et al. JOURNAL OF BIOMEDICAL OPTICS
- Region-specific permeability of the blood–brain barrier upon pericyte loss
- (2017) Roberto Villaseñor et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Age-associated changes in the blood-brain barrier: comparative studies in human and mouse
- (2017) E. F. Goodall et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Insulin and brain aging
- (2017) Agnieszka Baranowska-Bik et al. Przeglad Menopauzalny
- Crocin protects against cerebral- ischemia-induced damage in aged rats through maintaining the integrity of blood-brain barrier
- (2017) Xuan Zhang et al. RESTORATIVE NEUROLOGY AND NEUROSCIENCE
- Blood-brain barrier-supported neurogenesis in healthy and diseased brain
- (2017) Elena A. Pozhilenkova et al. REVIEWS IN THE NEUROSCIENCES
- Photodynamic opening of blood-brain barrier
- (2017) Oxana Semyachkina-Glushkovskaya et al. Biomedical Optics Express
- A microfluidic model of the blood–brain barrier to study permeabilization by pulsed electric fields
- (2017) M. Bonakdar et al. RSC Advances
- Differential Roles of Environmental Enrichment in Alzheimer’s Type of Neurodegeneration and Physiological Aging
- (2017) Vladimir V. Salmin et al. Frontiers in Aging Neuroscience
- Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease
- (2017) Roger J. Mullins et al. Frontiers in Aging Neuroscience
- Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs
- (2017) Justin Cohen et al. Frontiers in Aging Neuroscience
- Aging Microglia—Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases
- (2017) Björn Spittau Frontiers in Aging Neuroscience
- Insulin Resistance and Alzheimer’s Disease: Bioenergetic Linkages
- (2017) Bryan J. Neth et al. Frontiers in Aging Neuroscience
- Brain Aging: Uncovering Cortical Characteristics of Healthy Aging in Young Adults
- (2017) Sahil Bajaj et al. Frontiers in Aging Neuroscience
- Mitochondria in endothelial cells: Sensors and integrators of environmental cues
- (2017) Sergio Caja et al. Redox Biology
- Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells
- (2017) Abebe Muche et al. PLoS One
- In Vivo Imaging of Human Neuroinflammation
- (2016) Daniel S. Albrecht et al. ACS Chemical Neuroscience
- Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
- (2016) Alexandra Bernadotte et al. Aging-US
- Glial influences on BBB functions and molecular players in immune cell trafficking
- (2016) Marc-André Lécuyer et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
- (2016) Juliana Camacho-Pereira et al. Cell Metabolism
- Mitochondria are required for pro‐ageing features of the senescent phenotype
- (2016) Clara Correia‐Melo et al. EMBO JOURNAL
- In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use
- (2016) Hans C Helms et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Age-associated physiological and pathological changes at the blood–brain barrier: A review
- (2016) Franciska Erdő et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances
- (2016) Franz Bauernfeind et al. JOURNAL OF IMMUNOLOGY
- Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System
- (2016) Yan-Yan Zhang et al. MOLECULAR PHARMACEUTICS
- From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery
- (2016) William A. Banks NATURE REVIEWS DRUG DISCOVERY
- Sex differences in metabolic aging of the brain: insights into female susceptibility to Alzheimer's disease
- (2016) Liqin Zhao et al. NEUROBIOLOGY OF AGING
- NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
- (2016) H. Zhang et al. SCIENCE
- Neurogenic Niche Microglia Undergo Positional Remodeling and Progressive Activation Contributing to Age-Associated Reductions in Neurogenesis
- (2016) Rene Solano Fonseca et al. STEM CELLS AND DEVELOPMENT
- Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown
- (2016) Yu Yamazaki et al. STROKE
- Endothelial Progenitor Cells Physiology and Metabolic Plasticity in Brain Angiogenesis and Blood-Brain Barrier Modeling
- (2016) Natalia A. Malinovskaya et al. Frontiers in Physiology
- Microglia–blood vessel interactions: a double-edged sword in brain pathologies
- (2015) Nevenka Dudvarski Stankovic et al. ACTA NEUROPATHOLOGICA
- Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
- (2015) Jacquelyn A. Brown et al. Biomicrofluidics
- Male brain ages faster: the age and gender dependence of subcortical volumes
- (2015) András Király et al. Brain Imaging and Behavior
- Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
- (2015) Ram Madabhushi et al. CELL
- Insulin Resistance Predicts Medial Temporal Hypermetabolism in Mild Cognitive Impairment Conversion to Alzheimer Disease
- (2015) Auriel A. Willette et al. DIABETES
- Selective insulin resistance in hepatocyte senescence
- (2015) Aloysious Aravinthan et al. EXPERIMENTAL CELL RESEARCH
- Cellular senescence and the aging brain
- (2015) Shankar J. Chinta et al. EXPERIMENTAL GERONTOLOGY
- Glycolysis-mediated control of blood-brain barrier development and function
- (2015) Alla B. Salmina et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Cellular and molecular biology of aging endothelial cells
- (2015) Anthony J. Donato et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease
- (2015) Emma L. James et al. JOURNAL OF PROTEOME RESEARCH
- Blood-brain barrier modeling: challenges and perspectives
- (2015) Tobias Ruck et al. Neural Regeneration Research
- Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability
- (2015) Ruihe Lin et al. NEUROBIOLOGY OF DISEASE
- Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
- (2015) Axel Montagne et al. NEURON
- Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions
- (2015) Valentina Turinetto et al. NUCLEIC ACIDS RESEARCH
- Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart
- (2015) Levy A. Reyes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology
- (2015) Hansang Cho et al. Scientific Reports
- The age factor in Alzheimer’s disease
- (2015) Rita Guerreiro et al. Genome Medicine
- Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment
- (2015) Mina Elahy et al. Immunity & Ageing
- H2S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?
- (2015) Alla B. Salmina et al. Frontiers in Physiology
- Insulin, Aging, and the Brain: Mechanisms and Implications
- (2015) Abimbola A. Akintola et al. Frontiers in Endocrinology
- Astrocytic metabolic and inflammatory changes as a function of age
- (2014) Tianyi Jiang et al. AGING CELL
- Impairment of paravascular clearance pathways in the aging brain
- (2014) Benjamin T. Kress et al. ANNALS OF NEUROLOGY
- Blood–brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics
- (2014) Danica B Stanimirovic et al. Expert Opinion on Drug Discovery
- Phosphorylation of Histone H2AX in the Mouse Brain from Development to Senescence
- (2014) Serena Barral et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Aging-related differences in cerebral capillary blood flow in anesthetized rats
- (2014) Michèle Desjardins et al. NEUROBIOLOGY OF AGING
- Human Astrocytes: Secretome Profiles of Cytokines and Chemokines
- (2014) Sung S. Choi et al. PLoS One
- Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats
- (2014) Hui Qun Fu et al. PLoS One
- Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
- (2014) L. Katsimpardi et al. SCIENCE
- The impact of microglial activation on blood-brain barrier in brain diseases
- (2014) Anna Carolina Carvalho da Fonseca et al. Frontiers in Cellular Neuroscience
- Transcriptomics of Post-Stroke Angiogenesis in the Aged Brain
- (2014) Ana Maria Buga et al. Frontiers in Aging Neuroscience
- Vascular Hyperpermeability and Aging
- (2014) Aging and Disease
- Mitochondria and Endothelial Function
- (2013) Matthew A. Kluge et al. CIRCULATION RESEARCH
- Cardiac Aging and Insulin Resistance: Could Insulin/Insulin-Like Growth Factor (IGF) Signaling be used as a Therapeutic Target?
- (2013) Sihem Boudina CURRENT PHARMACEUTICAL DESIGN
- Oxidative stress and vascular inflammation in aging
- (2013) Mariam El Assar et al. FREE RADICAL BIOLOGY AND MEDICINE
- Healthy Aging by Staying Selectively Connected: A Mini-Review
- (2013) Daria Antonenko et al. GERONTOLOGY
- Endothelial adherens junctions at a glance
- (2013) E. Dejana et al. JOURNAL OF CELL SCIENCE
- Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?
- (2013) S. J. Chinta et al. JOURNAL OF INTERNAL MEDICINE
- Altered Synaptic Dynamics during Normal Brain Aging
- (2013) R. Mostany et al. JOURNAL OF NEUROSCIENCE
- Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease
- (2013) Z. Tucsek et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Blood–brain-barriers in aging and in Alzheimer’s disease
- (2013) Fernanda Marques et al. Molecular Neurodegeneration
- Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β
- (2013) Elsa Suberbielle et al. NATURE NEUROSCIENCE
- Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging
- (2013) Madhav Thambisetty et al. NEUROBIOLOGY OF AGING
- Complex and region-specific changes in astroglial markers in the aging brain
- (2013) José J. Rodríguez et al. NEUROBIOLOGY OF AGING
- Age-related changes in brain support cells: Implications for stroke severity
- (2013) Farida Sohrabji et al. NEUROCHEMISTRY INTERNATIONAL
- Impairments of tight junctions are involved in D-galactose-induced brain aging
- (2013) Ming Lei et al. NEUROREPORT
- Triggers and Effectors of Oxidative Stress at Blood-Brain Barrier Level: Relevance for Brain Ageing and Neurodegeneration
- (2013) Ana-Maria Enciu et al. Oxidative Medicine and Cellular Longevity
- High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway
- (2013) Rokhsana Mortuza et al. PLoS One
- Aging- and injury-related differential apoptotic response in the dentate gyrus of the hippocampus in rats following brain trauma
- (2013) Dong Sun et al. Frontiers in Aging Neuroscience
- CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice
- (2013) Shirin Akther et al. Molecular Brain
- The Endothelium Abridges Insulin Resistance to Premature Aging
- (2013) Angelo Avogaro et al. Journal of the American Heart Association
- Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes
- (2012) Claude A. Piantadosi et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Overview and introduction: The blood-brain barrier in health and disease
- (2012) N. Joan Abbott et al. EPILEPSIA
- P-Glycoprotein Function at the Blood–Brain Barrier: Effects of Age and Gender
- (2012) Daniëlle M. E. van Assema et al. MOLECULAR IMAGING AND BIOLOGY
- The ageing cortical synapse: hallmarks and implications for cognitive decline
- (2012) John H. Morrison et al. NATURE REVIEWS NEUROSCIENCE
- Review: Microglia of the aged brain: primed to be activated and resistant to regulation
- (2012) D. M. Norden et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells
- (2012) Jungmin Seo et al. NUCLEIC ACIDS RESEARCH
- Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence
- (2012) André Maicher et al. NUCLEIC ACIDS RESEARCH
- The Neuron-Astrocyte-Microglia Triad in Normal Brain Ageing and in a Model of Neuroinflammation in the Rat Hippocampus
- (2012) Francesca Cerbai et al. PLoS One
- Oxidative stress and cerebral endothelial cells: Regulation of the blood–brain-barrier and antioxidant based interventions
- (2011) Linnea R. Freeman et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- A possible crosstalk between DNA repair pathways and angiogenesis
- (2011) Triantafyllos Chavakis et al. CELL CYCLE
- Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch
- (2011) Fangfei Li et al. DEVELOPMENTAL CELL
- Mitochondria: Sovereign of inflammation?
- (2011) Jürg Tschopp EUROPEAN JOURNAL OF IMMUNOLOGY
- Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice
- (2011) Phil Lee et al. EXPERIMENTAL NEUROLOGY
- CD38 and its role in oxytocin secretion and social behavior
- (2011) Haruhiro Higashida et al. HORMONES AND BEHAVIOR
- Connexin Channels Provide a Target to Manipulate Brain Endothelial Calcium Dynamics and Blood—Brain Barrier Permeability
- (2011) Marijke De Bock et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons
- (2011) Ethan S. Lippmann et al. JOURNAL OF NEUROCHEMISTRY
- Reproductive Experience Affects Parental Retrieval Behaviour Associated with Increased Plasma Oxytocin Levels in Wild-Type and Cd38-Knockout Mice
- (2011) O. Lopatina et al. JOURNAL OF NEUROENDOCRINOLOGY
- The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability
- (2011) Christoph W. Blau et al. NEUROBIOLOGY OF AGING
- Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease
- (2011) Kaan E. Biron et al. PLoS One
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Healthy Brain Aging: A Road Map
- (2010) Abhilash K. Desai et al. CLINICS IN GERIATRIC MEDICINE
- Stress-induced senescence in human and rodent astrocytes
- (2010) Alessandro Bitto et al. EXPERIMENTAL CELL RESEARCH
- Amyloid Efflux Transporter Expression at the Blood-Brain Barrier Declines in Normal Aging
- (2010) Gerald D. Silverberg et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- The Blood-Brain Barrier: Geriatric Relevance of a Critical Brain-Body Interface
- (2010) Neer Zeevi et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling
- (2010) Ethan A Winkler et al. Molecular Neurodegeneration
- Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging
- (2010) Robert D. Bell et al. NEURON
- High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio
- (2010) J. M. Ross et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nicotinamide phosphoribosyltransferase imparts human endothelial cells with extended replicative lifespan and enhanced angiogenic capacity in a high glucose environment
- (2009) Nica M. Borradaile et al. AGING CELL
- CD38 as a Regulator of Cellular NAD: A Novel Potential Pharmacological Target for Metabolic Conditions
- (2009) Eduardo Chini CURRENT PHARMACEUTICAL DESIGN
- Evidence of angiogenic vessels in Alzheimer’s disease
- (2009) Brinda S. Desai et al. JOURNAL OF NEURAL TRANSMISSION
- Molecular Diversity of VEGF-A as a Regulator of Its Biological Activity
- (2009) Jeanette Woolard et al. MICROCIRCULATION
- Histone H2AX is integral to hypoxia-driven neovascularization
- (2009) Matina Economopoulou et al. NATURE MEDICINE
- Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes
- (2008) Na-Hye Myung et al. AGE
- Oxidative stress-induced disruption of epithelial and endothelial tight junctions
- (2008) Radhakrishna Rao Frontiers in Bioscience-Landmark
- Wnt/β-catenin signaling controls development of the blood–brain barrier
- (2008) Stefan Liebner et al. JOURNAL OF CELL BIOLOGY
- Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology
- (2008) Fabio Malavasi et al. PHYSIOLOGICAL REVIEWS
- Aging, gender, and the elderly adult brain: An examination of analytical strategies
- (2006) Daniel L. Greenberg et al. NEUROBIOLOGY OF AGING
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started