Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

(2016) Dipa Bhaumik et al.   Aging-US

Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin

(2016) Michael C. Velarde et al.   Aging-US

Repeated Lipopolysaccharide Stimulation Induces Cellular Senescence in BV2 Cells

(2012) Hong-Mei Yu et al.   NEUROIMMUNOMODULATION

Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease

(2012) Karlijn J. Doorn et al.   PROGRESS IN NEUROBIOLOGY

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Recent advances in (patho)physiology of astroglia

(2010) Alexei Verkhratsky et al.   ACTA PHARMACOLOGICA SINICA

Stress-induced senescence in human and rodent astrocytes

(2010) Alessandro Bitto et al.   EXPERIMENTAL CELL RESEARCH

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Biodemography of human ageing

(2010) James W. Vaupel   NATURE

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

(2010) Jean-Philippe Coppé et al.   PLoS One

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

ING1a expression increases during replicative senescence and induces a senescent phenotype

(2008) Mohamed A. Soliman et al.   AGING CELL

Aging-related changes in astrocytes in the rat retina: imbalance between cell proliferation and cell death reduces astrocyte availability

(2008) Hussein Mansour et al.   AGING CELL

The Aging Brain

(2008) Bruce A. Yankner et al.   Annual Review of Pathology-Mechanisms of Disease

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

(2008) Narendra Wajapeyee et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS

(2008) Tatyana A. Klimova et al.   FASEB JOURNAL

Iron-enhanced paraquat-mediated dopaminergic cell death due to increased oxidative stress as a consequence of microglial activation

(2008) Jun Peng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of Aging on Neuroprotective and Neurotoxic Properties of Microglia in Neurodegenerative Diseases

(2008) Makoto Sawada et al.   Neurodegenerative Diseases

Age-related expression of STUB1 in senescence-accelerated mice and its response to anti-Alzheimer's disease traditional Chinese medicine

(2008) Gui-Rong Zhang et al.   NEUROSCIENCE LETTERS

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY